A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis

Rating neurologic impairment in multiple sclerosis

1983 • 14,011 citations

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

2001 • 6,888 citations

Defining the clinical course of multiple sclerosis

1996 • 3,606 citations

Data analysis

1996 • 2,754 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

A Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis

2003 • 1,228 citations

The Autoimmune Diseases

2006 • 986 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging--measured disease activity and burden in patients with relapsing multiple sclerosis. European/Canadian Glatiramer Acetate Study Group.

2001 • 697 citations

European/Canadian multicenter, double‐blind, randomized, placebo‐controlled study of the effects of glatiramer acetate on magnetic resonance imaging–measured disease activity and burden in patients with relapsing multiple sclerosis

2001 • 595 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis

1990 • 447 citations

Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides

1989 • 416 citations

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

1993 • 400 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies.

1981 • 386 citations

Decreased FOXP3 levels in multiple sclerosis patients

2005 • 367 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis.

1991 • 237 citations

Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+ T Cells in Multiple Sclerosis

2004 • 230 citations

T Cell Receptor Peptide Therapy Triggers Autoregulation of Experimental Encephalomyelitis

1991 • 202 citations

The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease.

1993 • 197 citations

Treatment of multiple sclerosis with T–cell receptor peptides: Results of a double–blind pilot trial

1996 • 176 citations

Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis

1992 • 163 citations

T-cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls

2001 • 137 citations

Characterization of MRI response to treatment with interferon beta-1b: Contrast-enhancing MRI lesion frequency as a primary outcome measure

1997 • 124 citations

Changes in Activated T Cells in the Blood Correlate With Disease Activity in Multiple Sclerosis

2000 • 109 citations

Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic V beta 5.2 and V beta 6.1 CDR2 peptides.

1994 • 96 citations

T-cell Responses to Myelin Antigens in Multiple Sclerosis; Relevance of the Predominant Autoimmune Reactivity to Myelin Oligodendrocyte Glycoprotein

1998 • 84 citations

T cell receptor peptide vaccination in rheumatoid arthritis: A placebo-controlled trial using a combination of V?3, V?14, and V?17 Peptides

1998 • 74 citations

Surges of Increased T Cell Reactivity to an Encephalitogenic Region of Myelin Proteolipid Protein Occur More Often in Patients with Multiple Sclerosis Than in Healthy Subjects

2000 • 64 citations

Immunity to TCR peptides in multiple sclerosis. II. T cell recognition of V beta 5.2 and V beta 6.1 CDR2 peptides.

1994 • 63 citations

Defective suppressor cell function mediated by T8+ cell lines from patients with progressive multiple sclerosis.

1986 • 59 citations

Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis. II. Comparative analysis of TCR utilization in CSF T-cell populations before and after vaccination with a TCRVβ6 CDR2 peptide

1997 • 58 citations

TCR peptide therapy in human autoimmune diseases.

2001 • 50 citations

HPRT mutant T-cell lines from multiple sclerosis patients recognize myelin proteolipid protein peptides

1997 • 47 citations

Results of a phase I clinical trial of a T-cell receptor peptide vaccine in patients with multiple sclerosis. I. Analysis of T-cell receptor utilization in CSF cell populations

1997 • 45 citations

Studies of Vβ8 T cell receptor peptide treatment in experimental autoimmune encephalomyelitis

1992 • 33 citations

Specificity of regulatory CD4⁺CD25⁺ T cells for self‐T cell receptor determinants

2004 • 29 citations

Immunity to T Cell Receptor Peptides in Multiple Sclerosis. III. Preferential Immunogenicity of Complementarity-Determining Region 2 Peptides from Disease-Associated T Cell Receptor BV Genes*

1998 • 23 citations

Cross-sectional and longitudinal analysis of myelin-reactive T cells in patients with multiple sclerosis

2004 • 21 citations

Vaccination with a CDR2 BV6S2/6S5 peptide in adjuvant induces peptide‐specific T‐cell responses in patients with multiple sclerosis

2001 • 19 citations

Inhibitory Effects of Incomplete Freund's Adjuvant on Experimental Autoimmune Encephalomyelitis

2002 • 17 citations

MHC-restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR V? CDR2 peptides: Comparison with myelin basic protein-specific T cells

1996 • 16 citations

Diminished frequency of interleukin‐10‐secreting, T‐cell receptor peptide‐reactive T cells in multiple sclerosis patients might allow expansion of activated memory T cells bearing the cognate BV gene

2001 • 15 citations

Therapeutic application of T cell receptor peptides

1997 • 9 citations

Immunity to T cell receptor peptides: theory and applications

1994 • 8 citations

Idiotypic Regulation Directed at T-Cell Receptor Determinants1

2015 • 2 citations

Immunity to T-Cell Receptor: Suppressive Vaccination with DNA Encoding a Variable Region Gene of the T-Cell Receptor

2003 • 1 citations