Translational Mini-Review Series on Type 1 Diabetes: Immune-based therapeutic approaches for type 1 diabetes

Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes

2005 • 4,969 citations

The Biology of NKT Cells

2006 • 2,052 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Type 1 diabetes: new perspectives on disease pathogenesis and treatment

2001 • 1,477 citations

Retinopathy and Nephropathy in Patients with Type 1 Diabetes Four Years after a Trial of Intensive Therapy

2000 • 1,468 citations

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus

2002 • 1,189 citations

Insulin Needs after CD3-Antibody Therapy in New-Onset Type 1 Diabetes

2005 • 1,080 citations

TOWARD AN UNDERSTANDING OF NKT CELL BIOLOGY: Progress and Paradoxes

2005 • 1,013 citations

In Situ Characterization of Autoimmune Phenomena and Expression of HLA Molecules in the Pancreas in Diabetic Insulitis

1985 • 935 citations

Effects of Insulin in Relatives of Patients with Type 1 Diabetes Mellitus

2002 • 803 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Effects of Oral Insulin in Relatives of Patients With Type 1 Diabetes

2005 • 630 citations

A Single Course of Anti-CD3 Monoclonal Antibody hOKT3γ1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes

2005 • 622 citations

Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

2001 • 605 citations

The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice

2001 • 556 citations

From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells

2006 • 553 citations

β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

2001 • 513 citations

European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes

2004 • 506 citations

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

2004 • 482 citations

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

2005 • 417 citations

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

1991 • 384 citations

Affinity-purified human Interleukin I is cytotoxic to isolated islets of Langerhans

1986 • 321 citations

Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling

2006 • 318 citations

Peptide-based therapeutic vaccines for allergic and autoimmune diseases

2005 • 318 citations

A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation

2005 • 316 citations

A Randomized Trial of Intensive Insulin Therapy in Newly Diagnosed Insulin-Dependent Diabetes Mellitus

1989 • 314 citations

Insulin prophylaxis in individuals at high risk of type 1 diabetes

1993 • 303 citations

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

2006 • 303 citations

Suppressor T cells – they’re back and critical for regulation of autoimmunity!

2001 • 289 citations

Tr1 cells: From discovery to their clinical application

2006 • 272 citations

CTLA4Ig: Bridging the Basic Immunology with Clinical Application

2006 • 266 citations

Translational Mini-Review Series on Type 1 Diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes

2007 • 264 citations

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

1995 • 248 citations

Regulating the Immune Response to Transplants

2001 • 242 citations

Psoriasis as a Model for T-Cell–Mediated Disease

2002 • 237 citations

Testing the NKT cell hypothesis of human IDDM pathogenesis

2002 • 237 citations

HOW DO MONOCLONAL ANTIBODIES INDUCE TOLERANCE? A Role for Infectious Tolerance?

1998 • 223 citations

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

2005 • 220 citations

Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes

2005 • 220 citations

Testing the NKT cell hypothesis of human IDDM pathogenesis

2002 • 203 citations

The Deutsche Nicotinamide Intervention Study: an attempt to prevent type 1 diabetes. DENIS Group.

1998 • 196 citations

Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity

2005 • 191 citations

Pancreatic β-Cell Function and Immune Responses to Insulin After Administration of Intranasal Insulin to Humans At Risk for Type 1 Diabetes

2004 • 177 citations

Prevention or delay of Type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide

1991 • 176 citations

Limited Duration of Remission of Insulin Dependency in Children With Recent Overt Type I Diabetes Treated With Low-Dose Cyclosporin

1990 • 168 citations

CD40L Blockade Prevents Autoimmune Diabetes by Induction of Bitypic NK/DC Regulatory Cells

2002 • 159 citations

Effect of adjuvant therapy on development of diabetes in mouse and man

1994 • 157 citations

Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study

2005 • 148 citations

Genetic Control of Diabetes Progression

1997 • 148 citations

Activated NKT Cells Inhibit Autoimmune Diabetes through Tolerogenic Recruitment of Dendritic Cells to Pancreatic Lymph Nodes

2005 • 143 citations

Translational Mini-Review Series on Type 1 Diabetes: Immune-based therapeutic approaches for type 1 diabetes

2007 • 140 citations

Combination Therapy With Sirolimus and Interleukin-2 Prevents Spontaneous and Recurrent Autoimmune Diabetes in NOD Mice

2002 • 132 citations

Treatment With Granulocyte Colony−Stimulating Factor Prevents Diabetes in NOD Mice by Recruiting Plasmacytoid Dendritic Cells and Functional CD4+CD25+ Regulatory T-Cells

2005 • 130 citations

Anti-thymocyte globulin and prednisone immunotherapy of recent onset type 1 diabetes mellitus.

1985 • 126 citations

Immunological Characterization and Therapeutic Activity of an Altered-Peptide Ligand, NBI-6024, Based on the Immunodominant Type 1 Diabetes Autoantigen Insulin B-Chain (9–23) Peptide

2002 • 124 citations

Effect of Bacillus Calmette-Guerin vaccination on new-onset type 1 diabetes. A randomized clinical study.

1999 • 121 citations

Thirty Years of Investigating the Autoimmune Basis for Type 1 Diabetes

2005 • 110 citations

Diazoxide Treatment at Onset Preserves Residual Insulin Secretion in Adults with Autoimmune Diabetes

1996 • 108 citations

Heat‐shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double‐blind phase II study

2006 • 108 citations

Delay of Type I diabetes in high risk, first degree relatives by parenteral antigen administration: the Schwabing Insulin Prophylaxis Pilot Trial

1998 • 105 citations

Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice

2004 • 96 citations

Optimized autoantibody-based risk assessment in family members. Implications for future intervention trials.

1999 • 92 citations

Alefacept therapy produces remission for patients with chronic plaque psoriasis

2003 • 80 citations

Insulin in Oral Immune “Tolerance”: A One-Amino Acid Change in the B Chain Makes the Difference

1999 • 78 citations

Immunomodulation in Type 1 Diabetes by NBI‐6024, an Altered Peptide Ligand of the Insulin B₍₉₋₂₃₎ Epitope

2005 • 71 citations

Neonatal Bacille Calmette-Guerin Vaccination and Type 1 Diabetes

2005 • 71 citations

Cyclosporine Delays but does not Prevent Clinical Onset in Glucose Intolerant Pre-type 1 Diabetic Children

1996 • 70 citations

Elimination of Dietary Gluten Does Not Reduce Titers of Type 1 Diabetes-Associated Autoantibodies in High-Risk Subjects

2002 • 68 citations

Intranasally administered insulin intended for prevention of type 1 diabetes—a safety study in healthy adults

2003 • 65 citations

A randomized trial of nicotinamide and vitamin E in children with recent onset type 1 diabetes (IMDIAB IX)

2004 • 65 citations

Bacille Calmette-Guérin Vaccination and Incidence of IDDM in Montreal, Canada

1997 • 64 citations

Temporary Preservation of β-Cell Function by Diazoxide Treatment in Childhood Type 1 Diabetes

2004 • 64 citations

An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells

2005 • 63 citations

Predicting type 1 diabetes

2005 • 60 citations

Antigen‐specific immunotherapy for autoimmune disease: fighting fire with fire?

2001 • 59 citations

Effect of Bacille Calmette-Guérin Vaccination on C-Peptide Secretion in Children Newly Diagnosed With IDDM

1998 • 58 citations

Initial Results of Screening of Nondiabetic Organ Donors for Expression of Islet Autoantibodies

2006 • 57 citations

Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development

2005 • 56 citations

Coupling of oral human or porcine insulin to the B subunit of cholera toxin (CTB) overcomes critical antigenic differences for prevention of type I diabetes

2003 • 41 citations

Effects of Oral Insulin in Relatives of Patients With Type 1 Diabetes

2005 • 40 citations

A Two Year Observational Study of Nicotinamide and Intensive Insulin Therapy in Patients with Recent Onset Type I Diabetes Mellitus

2005 • 39 citations

Randomized Trial Comparing Nicotinamide and Nicotinamide Plus Cyclosporin in Recent Onset Insulin‐dependent Diabetes (IMDIAB 1)

1994 • 37 citations

Association of interferon-γ and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes

2006 • 31 citations

Linear Loss of Insulin Secretory Capacity During the Last Six Months Preceding IDDM: No effect of antiedematous therapy with ketotifen

1994 • 30 citations

Immunotherapy Targeting the CD40/CD154 Costimulatory Pathway for Treatment of Autoimmune Disease

2004 • 29 citations

Cyclosporin A treatment of young children with newly-diagnosed Type 1 (insulin-dependent) diabetes mellitus

1992 • 25 citations

Ingested IFN-αPreserves ResidualβCell Function in Type 1 Diabetes

2001 • 25 citations

Atorvastatin Fails to Prevent the Development of Autoimmune Diabetes Despite Inhibition of Pathogenic β-Cell–Specific CD8 T-Cells

2006 • 21 citations

Protection From Type 1 Diabetes in the Face of High Levels of Activated Autoaggressive Lymphocytes in a Viral Transgenic Mouse Model Crossed to the SV129 Strain

2001 • 15 citations

E1-INT (Transition Therapeutics/Novo Nordisk).

2005 • 10 citations

Secondary measures of immunologic efficacy in clinical trials

2006 • 4 citations