The many important facets of T-cell repertoire diversity

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

HLA and HIV-1: Heterozygote Advantage and B*35 - Cw*04 Disadvantage

1999 • 1,229 citations

Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones

1992 • 1,227 citations

A very high level of crossreactivity is an essential feature of the T-cell receptor

1998 • 930 citations

A Direct Estimate of the Human αβ T Cell Receptor Diversity

1999 • 893 citations

Negative selection of lymphocytes

1994 • 810 citations

Estimating the Precursor Frequency of Naive Antigen-specific CD8 T Cells

2002 • 584 citations

T-cell repertoire diversity and clonal expansions in normal and clinical samples

1995 • 562 citations

Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells

1993 • 527 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

STRUCTURAL BASIS OF T CELL RECOGNITION

1999 • 518 citations

Mice Lacking TdT: Mature Animals with an Immature Lymphocyte Repertoire

1993 • 437 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

2001 • 407 citations

The Crystal Structure of a T Cell Receptor in Complex with Peptide and MHC Class II

1999 • 400 citations

Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef

1999 • 387 citations

Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

2000 • 377 citations

Functional avidity maturation of CD8+ T cells without selection of higher affinity TCR

2001 • 349 citations

Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

1997 • 344 citations

A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity

2003 • 326 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses.

1994 • 317 citations

Direct Link Between mhc Polymorphism, T Cell Avidity, and Diversity in Immune Defense

2002 • 315 citations

Role of self-peptides in positively selecting the T-cell repertoire

1990 • 300 citations

Size Estimate of the αβ TCR Repertoire of Naive Mouse Splenocytes

2000 • 297 citations

The specificity of TCR/pMHC interaction

2002 • 295 citations

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.

1991 • 266 citations

Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove.

1995 • 254 citations

Dynamics and Requirements of T Cell Clonal Expansion In Vivo at the Single-Cell Level: Effector Function Is Linked to Proliferative Capacity

1999 • 253 citations

CDR3 loop flexibility contributes to the degeneracy of TCR recognition

2003 • 253 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

The Protection: The Unit of Humoral Immunity Selected by Evolution

1990 • 236 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Conserved T Cell Receptor Repertoire in Primary and Memory CD8 T Cell Responses to an Acute Viral Infection

1998 • 229 citations

TCRs with high affinity for foreign pMHC show self-reactivity

2002 • 217 citations

Diversity of Epitope and Cytokine Profiles for Primary and Secondary Influenza A Virus-Specific CD8+ T Cell Responses

2001 • 207 citations

Individual Variations in the Murine T Cell Response to a Specific Peptide Reflect Variability in Naive Repertoires

1998 • 192 citations

How the MHC selects Th1/Th2 immunity

1998 • 178 citations

Migration and Function of Antigen-Primed Nonpolarized T Lymphocytes in Vivo

2001 • 176 citations

Activated and Memory CD8+ T Cells Can Be Distinguished by Their Cytokine Profiles and Phenotypic Markers

2000 • 174 citations

The Cytotoxic T-Cell Response to Herpes Simplex Virus Type 1 Infection of C57BL/6 Mice Is Almost Entirely Directed against a Single Immunodominant Determinant

1999 • 158 citations

Receptor editing in developing T cells

2000 • 157 citations

Control of MHC Restriction by TCR V _α CDR1 and CDR2

1996 • 152 citations

T Cell Responses and Viral Escape

1998 • 145 citations

Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire

1995 • 143 citations

Stability and Diversity of T Cell Receptor Repertoire Usage during Lymphocytic Choriomeningitis Virus Infection of Mice

1998 • 141 citations

Most α/β T Cell Receptor Diversity Is Due to Terminal Deoxynucleotidyl Transferase

2001 • 141 citations

Diversity, functionality, and stability of the T cell repertoire derived in vivo from a single human T cell precursor

2000 • 137 citations

Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice.

1993 • 136 citations

The Shaping of the T Cell Repertoire

2001 • 134 citations

Swift Development of Protective Effector Functions in Naive Cd8+ T Cells against Malaria Liver Stages

2001 • 130 citations

The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition.

1993 • 117 citations

T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor β-chain CDR3 size determination: evidence for oligoclonal expansions in tumours and inflammatory diseases

1995 • 117 citations

Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection.

1992 • 107 citations

Positive Selection of Thymocytes

1995 • 103 citations

A transgenic mouse model to analyze CD8⁺effector T cell differentiationin vivo

1999 • 97 citations

HIV: current opinion in escapology

2002 • 94 citations

A Correlation between TCR Vα Docking on MHC and CD8 Dependence

2003 • 92 citations

Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias

1995 • 87 citations

Escape in One of Two Cytotoxic T-Lymphocyte Epitopes Bound by a High-Frequency Major Histocompatibility Complex Class I Molecule, Mamu-A*02: a Paradigm for Virus Evolution and Persistence?

2002 • 80 citations

Efficient immune responses in mice lacking N‐region diversity

1995 • 74 citations

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

2002 • 71 citations

Quantitation of peptide anchor residue contributions to class I major histocompatibility complex molecule binding.

1993 • 70 citations

Limitations in plasticity of the T-cell receptor repertoire.

1991 • 62 citations

Defining Parameters for Successful Immunocytotherapy of Persistent Viral Infection

2000 • 61 citations

Cytotoxic T lymphocytes directed against a tumor-specific mutated antigen display similar HLA tetramer binding but distinct functional avidity and tissue distribution

2002 • 57 citations

CD8⁺ T‐cell clones in old mice

1997 • 57 citations

Junctional Biases in the Naive TCR Repertoire Control the CTL Response to an Immunodominant Determinant of HSV-1

2000 • 55 citations

Contribution of CD4+, CD8+CD28+, and CD8+CD28- T cells to CD3+ lymphocyte homeostasis during the natural course of HIV-1 infection.

1998 • 54 citations

Uncertainties − discrepancies in immunology

2002 • 50 citations

MHC class I and non-MHC-linked capacity for generating an anti-viral CTL response determines susceptibility to CTL exhaustion and establishment of virus persistence in mice.

1994 • 49 citations

The influence of invariant chain on the positive selection of single T cell receptor specificities

1995 • 49 citations

Selection of CTL Escape Mutants in Mice Infected with a Neurotropic Coronavirus: Quantitative Estimate of TCR Diversity in the Infected Central Nervous System

1999 • 49 citations

Selection of escape mutants from immune recognition during HIV infection

2002 • 47 citations

Chronic Modulation of the TCR Repertoire in the Lymphoid Periphery

1999 • 46 citations

Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries.

1998 • 44 citations

Qualitative and Quantitative Requirements for CD4+ T Cell-Mediated Antiviral Protection

1999 • 44 citations

Quantitative analysis of the CD8⁺T–cell response to readily eliminated and persistent viruses

2000 • 41 citations

The Early Expression of Glycoprotein B from Herpes Simplex Virus Can Be Detected by Antigen-Specific CD8⁺T Cells

2003 • 41 citations

Somatic Reorganization of Immunoglobulin Genes during Lymphocyte Differentiation

1981 • 40 citations

Preferential Escape of Subdominant CD8+ T Cells During Negative Selection Results in an Altered Antiviral T Cell Hierarchy

2003 • 39 citations

Definition of Natural T Cell Antigens with Mimicry Epitopes Obtained from Dedicated Synthetic Peptide Libraries

1998 • 38 citations

MHC Polymorphism Can Enrich the T Cell Repertoire of the Species by Shifts in Intrathymic Selection

2000 • 34 citations

TCR alpha-chain usage can determine antigen-selected TCR beta-chain repertoire diversity.

1996 • 32 citations

Cumulative Inhibition of NK Cells and T Cells Resulting from Engagement of Multiple Inhibitory Ly49 Receptors

2001 • 32 citations

Cross‐reactivity in T‐cell antigen recognition

2001 • 29 citations

Functional consequences of a T cell receptor D beta 2 and J beta 2 gene segment deletion.

1990 • 28 citations

T cell receptor (TCR) recognition of MHC class I variants: intermolecular second-site reversion provides evidence for peptide/MHC conformational variation.

1996 • 27 citations

Ig gene hypermutation: A mechanism is due

2002 • 20 citations

Peptide Selection by an MHC H-2Kb Class I Molecule Devoid of the Central Anchor (“C”) Pocket

1998 • 20 citations

Evidence for a role for T cell receptors (TCR) in the effector phase of acute bone marrow graft rejection. TCR V beta 5 transgenic mice lack effector cells able to cause graft rejection.

1992 • 20 citations

Evidence for cooperation between TCR V region and junctional sequences in determining a dominant cytotoxic T lymphocyte response to herpes simplex virus glycoprotein B

1997 • 17 citations

The critical role of a solvent-exposed residue of an MHC class I- restricted peptide in MHC-peptide binding

1997 • 13 citations

Individuality of Ag-Selected and Preimmune TCR Repertoires

2001 • 9 citations

A dominant V β bias in the CTL response after HSV-1 infection is determined by peptide residues predicted to also interact with the TCR β -chain CDR3 fn2 fn2Thiswork was supported by the Australian Research Council, the Australian National Health and Medical Research Council and an Australian Research Council Senior Research Fellowship (to FRC).

1998 • 8 citations

THE CELLULAR BASIS OF IMMUNOLOGY

1961 • 3 citations