Complexities of applying nasal tolerance induction as a therapy for ongoing relapsing experimental autoimmune encephalomyelitis (EAE) in DA rats

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

1997 • 757 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1996 • 389 citations

The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production.

1993 • 317 citations

Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity

1993 • 280 citations

[29] Production and assay of antibodies to acetylcholine receptors

1981 • 277 citations

Suppressive vaccination with DNA encoding a variable region gene of the T–cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity

1996 • 244 citations

Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen.

1990 • 229 citations

The Purification and Characterization of Rat Gamma Interferon by Use of Two Monoclonal Antibodies

1986 • 204 citations

Conditions That Induce Tolerance in Mature CD4+ T Cells

1997 • 149 citations

Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant

1995 • 142 citations

Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4⁺ T cells precedes the development of tolerance in vivo

1996 • 137 citations

Antigen‐driven tissue‐specific suppression following oral tolerance: Orally administered myelin basic protein suppresses proteolipid protein‐induced experimental autoimmune encephalomyelitis in the SJL mouse

1994 • 121 citations

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic β cell neo-antigen

1995 • 121 citations

Suppression of murine chronic relapsing experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein.

1996 • 111 citations

Suppression of experimental autoimmune myasthenia gravis by oral administration of acetylcholine receptor

1993 • 110 citations

Acetylcholine receptor-reactive T and B cells in myasthenia gravis and controls.

1991 • 108 citations

Suppression of experimental autoimmune myasthenia gravis by nasal administration of acetylcholine receptor

1995 • 96 citations

Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens.

1993 • 87 citations

A comparative study of experimental autoimmune encephalomyelitis in Lewis and DA rats.

1995 • 70 citations

Treatment of Autoimmune Disease by Oral Tolerance to Autoantigens

1996 • 65 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 61 citations

Intranasal administration of retinal antigens suppresses retinal antigen-induced experimental autoimmune uveoretinitis.

1994 • 60 citations

Mucosal Tolerance in a Murine Model of Experimental Autoimmune Encephalomyelitisa

1996 • 55 citations

The Oral Administration of Low-Dose Antigen Induces Activation Followed by Tolerization, While High-Dose Antigen Induces Tolerance without Activation

1997 • 51 citations

Modulation of the immune response with T-cell epitopes: the ultimate goal for specific immunotherapy of autoimmune disease.

1994 • 27 citations

Antigen-specific immunotherapy of autoimmune disease: a commentary

1996 • 18 citations