Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

1995 • 1,903 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

Signalling through the high-affinity IgE receptor FcεRI

1999 • 730 citations

Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes.

1981 • 592 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

2000 • 506 citations

Anaphylaxis: A review of causes and mechanisms

2002 • 468 citations

A Pilot Trial of Cop 1 in Exacerbating–Remitting Multiple Sclerosis

1987 • 465 citations

Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis

2000 • 412 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

1990 • 363 citations

Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis.

1997 • 363 citations

A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor

1999 • 326 citations

Anaphylaxis

1991 • 320 citations

Multiple sclerosis

2004 • 305 citations

Multiple sclerosis: Comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells

2000 • 304 citations

Pathways of anaphylaxis in the mouse

2002 • 303 citations

T‐ and B‐cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis

2001 • 279 citations

Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+ T Cells in Multiple Sclerosis

2004 • 230 citations

Pathologic Role and Temporal Appearance of Newly Emerging Autoepitopes in Relapsing Experimental Autoimmune Encephalomyelitis

2000 • 212 citations

An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide

2001 • 187 citations

Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-gamma-producing (Th1) cells.

1992 • 163 citations

Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides.

1990 • 140 citations

Split tolerance of T_hl and T_h2 cells in tolerance to Theiler's murine encephalomyelitis virus

1993 • 107 citations

The role of mast cells in demyelination. 1. Myelin proteins are degraded by mast cell proteases and myelin basic protein and P2 can stimulate mast cell degranulation

1988 • 106 citations

Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice.

1989 • 98 citations

Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23

2002 • 96 citations

The role of mast cells in allergy and autoimmunity

2002 • 84 citations

Drastic Up-Regulation of FcεRI on Mast Cells Is Induced by IgE Binding Through Stabilization and Accumulation of FcεRI on the Cell Surface

2001 • 83 citations

Long Term Maintenance of IgE-Mediated Memory in Mast Cells in the Absence of Detectable Serum IgE

2003 • 68 citations

Characterization of new rat anti-mouse IgE monoclonals and their use along with chimeric IgE to further define the site that interacts with FcϵRII and FcϵRI

1991 • 55 citations

Thymic expression of the golli-myelin basic protein gene in the SJL/J mouse

1995 • 48 citations

Induction and Suppression of an Autoimmune Disease by Oligomerized T Cell Epitopes

2000 • 47 citations

Induction of IL-4-dependent, anaphylactic-type and IL-4-Independent, non-anaphylactic-type IgG1 antibodies is modulated by adjuvants

2000 • 41 citations

Safety profile of copolymer 1: Analysis of cumulative experience in the United States and Israel

1996 • 36 citations

Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis

2005 • 35 citations

Synthetic peptides that inhibit binding of the myelin basic protein 85-99 epitope to multiple sclerosis-associated HLA-DR2 molecules and MBP-specific T-cell responses

2001 • 20 citations

Deleted Work

1955 • 0 citations