MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death

MicroRNAs

2004 • 33,206 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

2007 • 9,934 citations

MicroRNA expression profiles classify human cancers

2005 • 9,457 citations

Oncomirs — microRNAs with a role in cancer

2006 • 6,877 citations

A microRNA expression signature of human solid tumors defines cancer gene targets

2006 • 5,638 citations

Prediction of Mammalian MicroRNA Targets

2003 • 5,070 citations

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

2002 • 4,860 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

2000 • 4,834 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

2004 • 4,068 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

2006 • 4,019 citations

MicroRNA Gene Expression Deregulation in Human Breast Cancer

2005 • 4,014 citations

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

2004 • 3,727 citations

MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing

2007 • 3,708 citations

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

2008 • 3,700 citations

RAS Is Regulated by the let-7 MicroRNA Family

2005 • 3,637 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

A microRNA polycistron as a potential human oncogene

2005 • 3,482 citations

miR-15 and miR-16 induce apoptosis by targeting BCL2

2005 • 3,424 citations

MicroRNAs Modulate Hematopoietic Lineage Differentiation

2003 • 3,241 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

2006 • 3,029 citations

MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer

2007 • 2,677 citations

The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation

2005 • 2,666 citations

A microRNA component of the p53 tumour suppressor network

2007 • 2,620 citations

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

2007 • 2,544 citations

MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

2005 • 2,530 citations

MicroRNA biogenesis: coordinated cropping and dicing

2005 • 2,443 citations

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

2000 • 2,422 citations

A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia

2005 • 2,391 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

2004 • 2,341 citations

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

2008 • 2,188 citations

Systematic variation in gene expression patterns in human cancer cell lines

2000 • 2,119 citations

bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

2003 • 2,012 citations

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

2006 • 2,006 citations

Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis

2007 • 1,949 citations

Dicer is essential for mouse development

2003 • 1,896 citations

Endogenous human microRNAs that suppress breast cancer metastasis

2008 • 1,838 citations

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

2007 • 1,818 citations

Requirement of bic/microRNA-155 for Normal Immune Function

2007 • 1,807 citations

MicroRNA-155 is induced during the macrophage inflammatory response

2007 • 1,765 citations

IAP proteins: blocking the road to death's door

2002 • 1,753 citations

MicroRNA-133 controls cardiac hypertrophy

2007 • 1,732 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

MicroRNA-Directed Cleavage of HOXB8 mRNA

2004 • 1,680 citations

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

2007 • 1,605 citations

miR-21-mediated tumor growth

2006 • 1,569 citations

Reduced accumulation of specific microRNAs in colorectal neoplasia.

2003 • 1,559 citations

A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation

2005 • 1,504 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

2006 • 1,494 citations

Regulation of the Germinal Center Response by MicroRNA-155

2007 • 1,476 citations

Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation

2002 • 1,426 citations

Selective Blockade of MicroRNA Processing by Lin28

2008 • 1,422 citations

Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis

2005 • 1,421 citations

Accumulation of miR-155 and BIC RNA in human B cell lymphomas

2005 • 1,324 citations

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

2000 • 1,307 citations

Widespread microRNA repression by Myc contributes to tumorigenesis

2007 • 1,300 citations

Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis

2007 • 1,297 citations

Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock

2007 • 1,264 citations

A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors

2006 • 1,251 citations

The role of microRNA genes in papillary thyroid carcinoma

2005 • 1,217 citations

The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells

2007 • 1,201 citations

miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection

2007 • 1,147 citations

The tumor suppressor microRNA let-7 represses the HMGA2 oncogene

2007 • 1,133 citations

Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells

2007 • 1,123 citations

p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes

2007 • 1,096 citations

The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

2007 • 1,092 citations

Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation

2007 • 1,092 citations

Extensive modulation of a set of microRNAs in primary glioblastoma

2005 • 1,090 citations

MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1)

2007 • 1,077 citations

The CD95(APO-1/Fas) DISC and beyond

2003 • 1,064 citations

Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster

2006 • 1,047 citations

microRNAs exhibit high frequency genomic alterations in human cancer

2006 • 1,029 citations

MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb

2007 • 1,022 citations

MicroRNA-143 Regulates Adipocyte Differentiation

2004 • 1,007 citations

The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism

2003 • 1,003 citations

A Minicircuitry Comprised of MicroRNA-223 and Transcription Factors NFI-A and C/EBPα Regulates Human Granulopoiesis

2005 • 979 citations

Apoptosis signaling by death receptors

1998 • 976 citations

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

2008 • 972 citations

An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues

2004 • 942 citations

Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer

2006 • 917 citations

Differential Regulation of microRNAs by p53 Revealed by Massively Parallel Sequencing: miR-34a is a p53 Target That Induces Apoptosis and G1-arrest

2007 • 914 citations

Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice

2006 • 913 citations

Expression profiling identifies microRNA signature in pancreatic cancer

2006 • 900 citations

Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

2007 • 883 citations

mir-29 regulates Mcl-1 protein expression and apoptosis

2007 • 829 citations

The Role of c-FLIP in Modulation of CD95-induced Apoptosis

1999 • 823 citations

Suppression of non-small cell lung tumor development by the let-7 microRNA family

2008 • 823 citations

Cyclin G1 Is a Target of miR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma

2007 • 814 citations

MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

2007 • 800 citations

Regulation of the p27Kip1 tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation

2007 • 793 citations

MicroRNA Let-7a Down-regulates MYC and Reverts MYC-Induced Growth in Burkitt Lymphoma Cells

2007 • 792 citations

miR-122, a Mammalian Liver-Specific microRNA, is Processed from hcr mRNA and MayDownregulate the High Affinity Cationic Amino Acid Transporter CAT-1

2004 • 786 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

MicroRNA Expression Abnormalities in Pancreatic Endocrine and Acinar Tumors Are Associated With Distinctive Pathologic Features and Clinical Behavior

2006 • 769 citations

MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation

2005 • 762 citations

A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans

2003 • 756 citations

Transcription and Processing of Human microRNA Precursors

2004 • 752 citations

miR-221 and miR-222 Expression Affects the Proliferation Potential of Human Prostate Carcinoma Cell Lines by Targeting p27Kip1

2007 • 740 citations

Identification and Characterization of a Novel Gene, C13orf25 , as a Target for 13q31-q32 Amplification in Malignant Lymphoma

2004 • 727 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

BIC and miR‐155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas

2005 • 676 citations

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

2008 • 665 citations

MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma

2007 • 661 citations

MicroRNA-34b and MicroRNA-34c Are Targets of p53 and Cooperate in Control of Cell Proliferation and Adhesion-Independent Growth

2007 • 639 citations

Interleukin-6–dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer

2007 • 629 citations

Downregulation of miR‐122 in the rodent and human hepatocellular carcinomas

2006 • 612 citations

let-7 MicroRNA Functions as a Potential Growth Suppressor in Human Colon Cancer Cells

2006 • 612 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

An E2F/miR-20a Autoregulatory Feedback Loop

2006 • 604 citations

miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely

2007 • 602 citations

Micro-RNA profiling in kidney and bladder cancers

2007 • 596 citations

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

2008 • 593 citations

The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation

2006 • 569 citations

Transcripts Targeted by the MicroRNA-16 Family Cooperatively Regulate Cell Cycle Progression

2007 • 557 citations

Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development

2007 • 548 citations

Mutations that lead to reiterations in the cell lineages of C. elegans

1981 • 530 citations

Tcl1 Expression in Chronic Lymphocytic Leukemia Is Regulated by miR-29 and miR-181

2006 • 512 citations

CD34+ hematopoietic stem-progenitor cell microRNA expression and function: A circuit diagram of differentiation control

2007 • 500 citations

Mir-17-5p Regulates Breast Cancer Cell Proliferation by Inhibiting Translation of AIB1 mRNA

2006 • 500 citations

The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans

2005 • 479 citations

Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells

2007 • 461 citations

Epigenetic inactivation of microRNA gene hsa‐mir‐9‐1 in human breast cancer

2007 • 455 citations

Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5

2007 • 449 citations

MicroRNAs 17-5p–20a–106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation

2007 • 448 citations

Let-7 expression defines two differentiation stages of cancer

2007 • 448 citations

The Human let-7a-3 Locus Contains an Epigenetically Regulated MicroRNA Gene with Oncogenic Function

2007 • 444 citations

The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes

2007 • 442 citations

Patterns of Known and Novel Small RNAs in Human Cervical Cancer

2007 • 425 citations

The CD95 Type I/Type II model

2003 • 415 citations

Principles and effects of microRNA-mediated post-transcriptional gene regulation

2006 • 410 citations

MicroRNA-21 Knockdown Disrupts Glioma Growth In vivo and Displays Synergistic Cytotoxicity with Neural Precursor Cell–Delivered S-TRAIL in Human Gliomas

2007 • 407 citations

MicroRNA fingerprints during human megakaryocytopoiesis

2006 • 400 citations

Microrna expression distinguishes between germinal center B cell‐like and activated B cell‐like subtypes of diffuse large B cell lymphoma

2007 • 397 citations

The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development

2005 • 392 citations

Determinants of targeting by endogenous and exogenous microRNAs and siRNAs

2007 • 382 citations

Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92

2007 • 365 citations

Human microRNA-155 on Chromosome 21 Differentially Interacts with Its Polymorphic Target in the AGTR1 3′ Untranslated Region: A Mechanism for Functional Single-Nucleotide Polymorphisms Related to Phenotypes

2007 • 362 citations

Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells

2007 • 355 citations

Principles of microRNA regulation of a human cellular signaling network

2006 • 346 citations

Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL−/− mice

2003 • 345 citations

MicroRNA-9 Controls the Expression of Granuphilin/Slp4 and the Secretory Response of Insulin-producing Cells

2006 • 342 citations

Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid

2000 • 342 citations

Essential role for Dicer during skeletal muscle development

2007 • 323 citations

An Evolutionarily Conserved Mechanism for MicroRNA-223 Expression Revealed by MicroRNA Gene Profiling

2007 • 322 citations

Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells

2003 • 296 citations

Downregulation of microRNAs‐143 and ‐145 in B‐cell malignancies

2007 • 291 citations

Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma

2006 • 286 citations

Hypermethylation of let-7a-3 in Epithelial Ovarian Cancer Is Associated with Low Insulin-like Growth Factor-II Expression and Favorable Prognosis

2007 • 278 citations

Competing Interactions between Micro-RNAs Determine Neural Progenitor Survival and Proliferation after Ethanol Exposure: Evidence from anEx VivoModel of the Fetal Cerebral Cortical Neuroepithelium

2007 • 276 citations

High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma

2007 • 274 citations

Principles of micro-RNA production and maturation

2006 • 259 citations

Reduction of TRAIL-Induced Mcl-1 and cIAP2 by c-Myc or Sorafenib Sensitizes Resistant Human Cancer Cells to TRAIL-Induced Death

2007 • 254 citations

Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity

2008 • 251 citations

miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia

2007 • 249 citations

The role of the Bcl-2 protein family in cancer

2003 • 245 citations

Hematopoietic-specific microRNA expression in human cells

2005 • 243 citations

Let-7 Prevents Early Cancer Progression by Suppressing Expression of the Embryonic Gene HMGA2

2007 • 241 citations

Oncogenic Potential of the miR-106-363 Cluster and Its Implication in Human T-Cell Leukemia

2007 • 239 citations

The role of receptor internalization in CD95 signaling

2006 • 234 citations

Lack of BIC and microRNA miR‐155 expression in primary cases of Burkitt lymphoma

2005 • 222 citations

Combined Deficiency of Proapoptotic Regulators Bim and Fas Results in the Early Onset of Systemic Autoimmunity

2008 • 216 citations

Enhanced and accelerated lymphoproliferation in Fas-null mice.

1996 • 211 citations

Identification of Let-7–Regulated Oncofetal Genes

2008 • 209 citations

Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells

2007 • 207 citations

Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis

2007 • 199 citations

The MicroRNA let-7a Modulates Interleukin-6-dependent STAT-3 Survival Signaling in Malignant Human Cholangiocytes

2007 • 197 citations

Apoptosis Regulators Bim and Fas Function Concurrently to Control Autoimmunity and CD8+ T Cell Contraction

2008 • 190 citations

Expression of Mesenchyme-Specific Gene HMGA2 in Squamous Cell Carcinomas of the Oral Cavity

2004 • 190 citations

Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis

2007 • 187 citations

Increased expression of high mobility group A proteins in lung cancer

2006 • 185 citations

The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias.

1995 • 183 citations

Characterization of the in vivo function of TNF-α-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice

2002 • 177 citations

Reciprocal expression of lin‐41 and the microRNAs let‐7 and mir‐125 during mouse embryogenesis

2005 • 173 citations

A Role for Fas in Negative Selection of Thymocytes In Vivo

1998 • 167 citations

Fas Modulation of Apoptosis during Negative Selection of Thymocytes

1996 • 162 citations

MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3

2007 • 142 citations

A Genetic Screen Implicates miRNA-372 and miRNA-373 as Oncogenes in Testicular Germ Cell Tumors

2007 • 131 citations

A Central Role for Bid in Granzyme B-induced Apoptosis

2004 • 123 citations

Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia.

1989 • 122 citations

Two CD95 tumor classes with different sensitivities to antitumor drugs

2003 • 116 citations

An increased high-mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissue

2003 • 114 citations

Apoptosis-independent functions of killer caspases

2002 • 109 citations

Myc translocations in B cell and plasma cell neoplasms

2006 • 100 citations

Independent Repressor Domains in ZEB Regulate Muscle and T-Cell Differentiation

1999 • 96 citations

miR-7b, a microRNA up-regulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation

2006 • 94 citations

TNF Receptor-Deficient Mice Reveal Striking Differences Between Several Models of Thymocyte Negative Selection

1998 • 84 citations

An IL-2-Dependent Switch Between CD95 Signaling Pathways Sensitizes Primary Human T Cells Toward CD95-Mediated Activation-Induced Cell Death

2003 • 74 citations

miRNAs: Micro Managers of Programmed Cell Death

2003 • 72 citations

Normal Thymocyte Negative Selection in TRAIL-deficient Mice

2003 • 72 citations

What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain

2007 • 70 citations

MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells

2004 • 67 citations

Transcriptional Repression of the IL-2 Gene in Th Cells by ZEB

1998 • 66 citations

1p36: Every subband a suppressor?

1995 • 63 citations

Extracellular Signal-Regulated Kinase Induces the Megakaryocyte GPIIb/CD41 Gene through MafB/Kreisler

2004 • 53 citations

Negative regulation of CD4 expression in T cells by the transcriptional repressor ZEB

1999 • 51 citations

Recognition and Cleavage of Primary MicroRNA Transcripts

2006 • 46 citations

Expression of the HMGI(Y) gene products in human neuroblastic tumours correlates with differentiation status

2000 • 44 citations

Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation

2007 • 36 citations