MicroRNA Let-7a Down-regulates MYC and Reverts MYC-Induced Growth in Burkitt Lymphoma Cells

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

RAS Is Regulated by the let-7 MicroRNA Family

2005 • 3,637 citations

A microRNA polycistron as a potential human oncogene

2005 • 3,482 citations

MicroRNAs Modulate Hematopoietic Lineage Differentiation

2003 • 3,241 citations

MicroRNA maturation: stepwise processing and subcellular localization

2002 • 2,410 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

The Drosha-DGCR8 complex in primary microRNA processing

2004 • 2,096 citations

A microRNA in a Multiple-Turnover RNAi Enzyme Complex

2002 • 2,052 citations

Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.

2006 • 1,957 citations

Identification of Virus-Encoded MicroRNAs

2004 • 1,571 citations

Cleavage of Scarecrow-like mRNA Targets Directed by a Class of Arabidopsis miRNA

2002 • 1,569 citations

Reverse engineering of regulatory networks in human B cells

2005 • 1,408 citations

Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

2005 • 1,311 citations

c-MYC: more than just a matter of life and death

2002 • 1,147 citations

Genomic targets of the human c-Myc protein

2003 • 956 citations

Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc

2000 • 816 citations

Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC

2002 • 639 citations

Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

2002 • 624 citations

let-7 MicroRNA Functions as a Potential Growth Suppressor in Human Colon Cancer Cells

2006 • 612 citations

An E2F/miR-20a Autoregulatory Feedback Loop

2006 • 604 citations

The MYC protein activates transcription of the alpha-prothymosin gene.

1991 • 589 citations

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

2003 • 574 citations

Sensitive, high-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated copies of EBV in a lymphoma line

1988 • 550 citations

Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells.

1984 • 502 citations

Mir-17-5p Regulates Breast Cancer Cell Proliferation by Inhibiting Translation of AIB1 mRNA

2006 • 500 citations

New light on Myc and Myb. Part II. Myb.

1990 • 487 citations

Direct Regulation of an Oncogenic Micro-RNA Cluster by E2F Transcription Factors

2006 • 470 citations

Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.

1997 • 447 citations

MicroRNAs and cancer

2003 • 443 citations

Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions

2006 • 434 citations

Low molecular weight inhibitors of Myc–Max interaction and function

2003 • 410 citations

The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

1993 • 392 citations

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

2004 • 390 citations

The molecular role of Myc in growth and transformation: recent discoveries lead to new insights

1998 • 381 citations

Evidence that microRNAs are associated with translating messenger RNAs in human cells

2006 • 330 citations

The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation

1999 • 316 citations

Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29

1982 • 299 citations

MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision

2005 • 267 citations

Antibodies to Human c- myc Oncogene Product: Evidence of an Evolutionarily Conserved Protein Induced During Cell Proliferation

1984 • 200 citations

Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation

2004 • 168 citations

Visualization of Myc/Max/Mad Family Dimers and the Competition for Dimerization in Living Cells

2004 • 164 citations

Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch

2006 • 147 citations

Conditional transgenic models define how MYC initiates and maintains tumorigenesis

2006 • 144 citations

Proteins Encoded by the Human c-myc Oncogene: Differential Expression in Neoplastic Cells

1984 • 138 citations

Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations

2003 • 117 citations

Tumor Dormancy and MYC Inactivation: Pushing Cancer to the Brink of Normalcy

2005 • 103 citations

Reversible lymphomagenesis in conditionally c‐MYC expressing mice

2004 • 80 citations

miRNAs: Micro Managers of Programmed Cell Death

2003 • 72 citations

Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene product

2002 • 54 citations

c-Myc inhibition negatively impacts lymphoma growth

2006 • 46 citations

Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis.

2004 • 39 citations