Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL−/− mice

Mitochondria and Apoptosis

1998 • 8,909 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

1999 • 2,494 citations

Safety and antitumor activity of recombinant soluble Apo2 ligand

1999 • 2,215 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

1997 • 1,694 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL

1997 • 1,119 citations

Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

2000 • 847 citations

FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2

2000 • 792 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

1997 • 685 citations

TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

1997 • 683 citations

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

2000 • 651 citations

Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice

2002 • 608 citations

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1998 • 504 citations

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO

2002 • 448 citations

CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons

1999 • 435 citations

p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.

1998 • 363 citations

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Is an Inhibitor of Autoimmune Inflammation and Cell Cycle Progression

2000 • 357 citations

TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL

1997 • 331 citations

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

1998 • 327 citations

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice

1996 • 325 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

Characterization of two receptors for TRAIL¹

1997 • 293 citations

An endogenous retrovirus mediating deletion of αβ T cells?

1991 • 278 citations

TRAIL/Apo-2-ligand-induced apoptosis in human T cells

1998 • 273 citations

A Role for FADD in T Cell Activation and Development

1998 • 241 citations

Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.

1999 • 236 citations

The Death Domain Kinase RIP Is Essential for TRAIL (Apo2L)-Induced Activation of IκB Kinase and c-Jun N-Terminal Kinase

2000 • 225 citations

Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression.

1995 • 222 citations

Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptors Signal NF-κB and JNK Activation and Apoptosis through Distinct Pathways

1999 • 217 citations

Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by smac/DIABLO release from mitochondria.

2001 • 203 citations

Differential regulation of TRAIL and CD95 ligand in transformed cells of the T and B lymphocyte lineage

1998 • 195 citations

Characterization of the in vivo function of TNF-α-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice

2002 • 177 citations

A Role for Fas in Negative Selection of Thymocytes In Vivo

1998 • 167 citations

Fas Modulation of Apoptosis during Negative Selection of Thymocytes

1996 • 162 citations

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.

1996 • 161 citations

Death Ligand TRAIL Induces No Apoptosis but Inhibits Activation of Human (Auto)antigen-Specific T Cells

2002 • 132 citations

Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus-mediated autoimmune diabetes

2002 • 121 citations

In Situ β Cell Death Promotes Priming of Diabetogenic CD8 T Lymphocytes

2002 • 103 citations

Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus-mediated autoimmune diabetes

2002 • 103 citations

Molecular Cross-talk between the TRAIL and Interferon Signaling Pathways

2002 • 102 citations

TNF Receptor-Deficient Mice Reveal Striking Differences Between Several Models of Thymocyte Negative Selection

1998 • 84 citations

Influence of Viral Superantigens on Vβ‐and Vα Specific Positive and Negative Selection

1993 • 83 citations

Tumor necrosis factor-related apoptosis-inducing ligand in T cell development: Sensitivity of human thymocytes

2001 • 70 citations

Low Dose Streptozotocin-Induced Diabetes in Rat Insulin Promoter-mCD80-Transgenic Mice Is T Cell Autoantigen-Specific and CD28 Dependent

2001 • 34 citations

Molecular and Functional Properties of Novel T Cell Subsets in C3H‐gld/gld and Nude Mice. Implications for Thymic and Extrathymic Maturation

1988 • 33 citations

Clonal deletion of major histocompatibility complex class I‐restricted CD4⁺CD8⁺ thymocytes in vitro is independent of the CD95 (APO‐1/Fas) ligand

1995 • 21 citations

Discovery and characterization of differentially-regulated genes in the chondrocytic cell line T/C-28a2 under dynamic fluid shear

2002 • 4 citations