Myc translocations in B cell and plasma cell neoplasms

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Transcriptional regulation and transformation by Myc proteins

2005 • 1,102 citations

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

2001 • 1,020 citations

A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy

2002 • 1,009 citations

Mechanisms of B-cell lymphoma pathogenesis

2005 • 902 citations

myc FUNCTION AND REGULATION

1992 • 790 citations

Marker Band in One Chromosome 14 from Burkitt Lymphomas

1972 • 628 citations

H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

2003 • 545 citations

Translocation and Rearrangements of the c- myc Oncogene Locus in Human Undifferentiated B-Cell Lymphomas

1983 • 514 citations

Chromosome translocations in multiple myeloma

2001 • 481 citations

Histone H2AX

2003 • 479 citations

Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas

1982 • 471 citations

Translocations involving c-myc and c-myc function

2001 • 465 citations

Myc pathways provoking cell suicide and cancer

2003 • 461 citations

AID Is Required for c-myc/IgH Chromosome Translocations In Vivo

2004 • 449 citations

Lymphoid Malignancies: the dark side of B-cell differentiation

2002 • 421 citations

Spatial proximity of translocation-prone gene loci in human lymphomas

2003 • 408 citations

Mechanism and control of class-switch recombination

2002 • 379 citations

Tissue-specific spatial organization of genomes

2004 • 360 citations

Activation Of Cellular Oncogenes in Hemopoietic Cells by Chromosome Translocation

1986 • 354 citations

Diverse karyotypic abnormalities of the c -myc locus associated with c -myc dysregulation and tumor progression in multiple myeloma

2000 • 344 citations

Deconstructing Myc: Figure 1.

2001 • 311 citations

Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer

1997 • 300 citations

Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences

2005 • 296 citations

Point mutations in the c–Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas

1993 • 283 citations

Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors

2001 • 272 citations

Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells.

1994 • 258 citations

A site–directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination

1995 • 257 citations

Different regions of the immunoglobulin heavy-chain locus are involved in chromosomal translocations in distinct pathogenetic forms of Burkitt lymphoma.

1988 • 245 citations

Nonrandom chromosome changes involving the Ig gene-carrying chromosomes 12 and 6 in pristane-induced mouse plasmacytomas

1979 • 209 citations

Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells

2005 • 191 citations

Conservation of Relative Chromosome Positioning in Normal and Cancer Cells

2002 • 190 citations

Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations

1992 • 187 citations

Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene.

1985 • 180 citations

A variant translocation places the λ immunoglobulin genes 3′ to the c-myc oncogene in Burkitt's lymphoma

1984 • 145 citations

Molecular and Clinical Features of Non-Burkitt’s, Diffuse Large-Cell Lymphoma of B-Cell Type Associated With the c-MYC/Immunoglobulin Heavy-Chain Fusion Gene

2000 • 144 citations

IL-6 transgenic mouse model for extraosseous plasmacytoma

2002 • 133 citations

Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc induced pre-B cell lymphomas and SV40 large T gene a variety of tumors in transgenic mice.

1987 • 129 citations

Translocation of the myc cellular oncogene to the immunoglobulin heavy chain locus in murine plasmacytomas is an imprecise reciprocal exchange

1984 • 128 citations

Neoplastic development in plasma cells

2003 • 125 citations

Chromatin Architecture near a Potential 3′ End of the Igh Locus Involves Modular Regulation of Histone Modifications during B-Cell Development and In Vivo Occupancy at CTCF Sites

2005 • 123 citations

Reconstructing MYC: Figure 1.

2003 • 123 citations

Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model.

1988 • 118 citations

Mantle Cell Lymphoma with 8q24 Chromosomal Abnormalities: a Report of 5 Cases with Blastoid Features

2002 • 113 citations

Insertion of c-MycintoIghInduces B-Cell and Plasma-Cell Neoplasms in Mice

2005 • 113 citations

Novel targeted deregulation of c-Myc cooperates with Bcl-XL to cause plasma cell neoplasms in mice

2004 • 106 citations

Chromosome translocation can occur on either side of the c-myc oncogene in Burkitt lymphoma cells

1984 • 100 citations

Novel targeted deregulation of c-Myc cooperates with Bcl-XL to cause plasma cell neoplasms in mice

2004 • 92 citations

Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes

1990 • 91 citations

Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch.

1989 • 87 citations

Efficiency Alleles of the Pctr1 Modifier Locus for Plasmacytoma Susceptibility

2001 • 84 citations

Reversible lymphomagenesis in conditionally c‐MYC expressing mice

2004 • 80 citations

Early Genetic Events Provide the Basis for a Clinical Classification of Multiple Myeloma

2005 • 77 citations

Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men.

1995 • 73 citations

Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc

2004 • 72 citations

Activation of the c-myc oncogene by the immunoglobulin heavy-chain gene enhancer after multiple switch region-mediated chromosome rearrangements in a murine plasmacytoma.

1985 • 67 citations

A conserved sequence at c-myc oncogene chromosomal translocation breakpoints in plasmacytomas

1984 • 63 citations

DNA sequences near the site of reciprocal recombination between a c-myc oncogene and an immunoglobulin switch region.

1983 • 63 citations

Checkpoint responses to replication stalling: inducing tolerance and preventing mutagenesis

2003 • 62 citations

Detection of recombinations between c-myc and immunoglobulin switch alpha in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction.

1993 • 61 citations

The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line

2000 • 59 citations

Molecular heterogeneity of sporadic adult Burkitt-type leukemia/lymphoma as revealed by PCR and cytogenetics: correlation with morphology, immunology and clinical features

2005 • 58 citations

Regulatory Elements in the Immunoglobulin Heavy Chain Gene 3′-Enhancers Induce c-myc Deregulation and Lymphomagenesis in Murine B Cells

2005 • 52 citations

Deletional remodeling of c-myc-deregulating chromosomal translocations

1997 • 48 citations

Previously hidden chromosome aberrations in T(12;15)-positive BALB/c plasmacytomas uncovered by multicolor spectral karyotyping.

1997 • 48 citations

Strain dependency of B and T lymphoma development in immunoglobulin heavy chain enhancer (E mu)-myc transgenic mice.

1989 • 46 citations

Non‐random chromosomal changes involving chromosomes 6 and 7 in spontaneous rat immunocytomas

1982 • 45 citations

Pvt-1 transcripts are found in normal tissues and are altered by reciprocal(6;15) translocations in mouse plasmacytomas.

1990 • 43 citations

Follicular Lymphoma With a Burkitt Translocation—Predictor of an Aggressive Clinical Course: A Case Report and Review of the Literature

2004 • 42 citations

Level of MYC overexpression in pediatric Burkitt's lymphoma is strongly dependent on genomic breakpoint location within the MYC locus

2004 • 42 citations

Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2‐positive germinal center B‐cell lymphomas

2005 • 42 citations

Concurrent translocation of BCL2 and MYC with a single immunoglobulin locus in high-grade B-cell lymphomas

2005 • 41 citations

The invertor knock-in conditional chromosomal translocation mimic

2004 • 39 citations

Combined polymerase chain reaction methods to detect c-myc/IgH rearrangement in childhood Burkitt's lymphoma for minimal residual disease analysis.

2004 • 37 citations

6;7 Chromosomal Translocation in Spontaneously Arising Rat Immunocytomas: Evidence for c-myc Breakpoint Clustering and Correlation Between Isotypic Expression and the c-myc Target

1988 • 34 citations

The Plasmacytoma Resistance Gene, Pctr2, Delays the Onset of Tumorigenesis and Resides in the Telomeric Region of Chromosome 4

1997 • 34 citations

Differences between Burkitt's lymphomas and mouse plasmacytomas in the immunoglobulin heavy chain/c-myc recombinations that occur in their chromosomal translocations.

1995 • 33 citations

Chromosomal translocations deregulating c-myc are associated with normal immune responses

1997 • 33 citations

Heterogeneous pattern of chromosomal breakpoints involving the MYC locus in multiple myeloma

2003 • 32 citations

BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations.

2003 • 32 citations

Secondary deletional recombination of rearranged switch region in Ig isotype-switched B cells. A mechanism for isotype stabilization.

1995 • 32 citations

Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage

1988 • 31 citations

Migration of Cells With Immunoglobulin/c-myc Recombinations in Lymphoid Tissues of Mice

1997 • 31 citations

B-cell tumorigenesis in mice carrying a yeast artificial chromosome-based immunoglobulin heavy/c-myc translocus is independent of the heavy chain intron enhancer (Emu).

1999 • 31 citations

Differences in the molecular structure of c-myc-activating recombinations in murine plasmacytomas and precursor cells.

1994 • 31 citations

6;7 chromosomal translocation in spontaneously arising rat immunocytomas: evidence for c-myc breakpoint clustering and correlation between isotypic expression and the c-myc target.

1988 • 30 citations

Rapid induction of B-cell lymphomas in mice carrying a human IgH/c-mycYAC

1997 • 28 citations

Insertion of Myc into Igh Accelerates Peritoneal Plasmacytomas in Mice

2005 • 28 citations

Chromosomes, positions please!

2003 • 27 citations

Coexistent Rearrangements of c-MYC,BCL2, andBCL6 Genes in a Diffuse Large B-Cell Lymphoma

2004 • 26 citations

Molecular-cytogenetic Characterization of Non-Hodgkin's Lymphoma with Double and Cryptic Translocations of the Immunoglobulin Heavy Chain Gene

2004 • 25 citations

Conformational differences in the 3-D nanostructure of the immunoglobulin heavy-chain locus, a hotspot of chromosomal translocations in B lymphocytes

2001 • 25 citations

Detection of immunoglobulin/c-myc recombinations in mice that are resistant to plasmacytoma induction.

1996 • 25 citations

The Pathogenetic Role of Oncogenes Deregulated by Chromosomal Translocation in B-Cell Malignancies

2003 • 23 citations

Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) translocated plasma cells that contain illegitimate exchanges between the immunoglobulin heavy-chain μ locus and c-myc

2000 • 22 citations

Immunoglobulin/Myc recombinations in Murine Peyer's patch follicles

1997 • 20 citations

Nonrandom chromosomal change (trisomy 11) in murine plasmacytomas induced by an ABL-MYC retrovirus.

1995 • 20 citations

Clonal diversification of primary BALB/c plasmacytomas harboring T(12;15) chromosomal translocations

2000 • 20 citations

A new variant 15; 16 translocation in mouse plasmacytoma leads to the juxtaposition of c-myc and immunoglobulin lambda.

1991 • 19 citations

A switch region inversion contributes to the aberrant rearrangement of a μ. immnnoglobulin heavy chain gene in MPC-11 cells

1982 • 16 citations

DNA repair defects associated with chromosomal translocation breaksite regions.

1994 • 14 citations

Jumping Translocation Breakpoint Regions Lead to Amplification of Rearranged Myc

1999 • 12 citations

A Complex Translocation at the Murine K Light-Chain Locus

1987 • 12 citations

The “missing” mouse plasmacytoma (MPC) associated translocation T(15;16) occurs repeatedly in new MPC induction systems

1990 • 10 citations

Elevated mutant frequencies in lymphoid tissues persist throughout plasmacytoma development in BALB/c.lambdaLIZ mice.

1999 • 10 citations

The impact of p53 loss on murine plasmacytoma development.

2002 • 9 citations

A complex translocation at the murine kappa light-chain locus.

1987 • 9 citations

c‐myc Gene in a murine plasmocytoma without visible chromosomal translocations moves to chromosome 12f1 with pvt‐1 and rearranges with IgH enhancer‐Sμ sequences

1991 • 9 citations

Translocation remodeling in the primary BALB/c plasmacytoma TEPC 3610

2001 • 9 citations

A xeno-transplantable plasma cell leukemia line with a split translocation of the IgH gene

2003 • 9 citations

Eμ/Sμ transposition into Myc is sometimes a precursor for T(12;15) translocation in mouse B cells

2003 • 7 citations

Location of Myc, Igh, and Igk on Robertsonian fusion chromosomes is inconsequential for Myc translocations and plasmacytoma development in mice, but Rb(6.15)‐carrying tumors prefer Igk–Myc inversions over translocations

2005 • 6 citations

Isotype switch‐mediated C_H deletions are a recurrent feature of Myc/C_H translocations in peritoneal plasmacytomas in mice

2002 • 5 citations

Generation of Immunoglobulin/c-myc Recombinations in Murine Peyer’s Patch Follicles

1997 • 4 citations

Translocations into human chromosome 14 JH region: factors influencing downstream abortive immunoglobulin class switching

2003 • 4 citations

Long distance polymerase chain reaction of ascites lymphoma cells aids diagnosis establishment of abdominal Burkitt's lymphoma and Burkitt-like lymphoma

2004 • 4 citations

Recurrent Non-reciprocal Translocations of Chromosome 5 in Primary T(12;15)-positive BALB/c Plasmacytomas

1999 • 3 citations