Widespread microRNA repression by Myc contributes to tumorigenesis

MicroRNA expression profiles classify human cancers

2005 • 9,457 citations

MicroRNA signatures in human cancers

2006 • 7,358 citations

A microRNA expression signature of human solid tumors defines cancer gene targets

2006 • 5,638 citations

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

2002 • 4,860 citations

MicroRNA genes are transcribed by RNA polymerase II

2004 • 4,200 citations

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

2004 • 4,068 citations

NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

2006 • 4,019 citations

RAS Is Regulated by the let-7 MicroRNA Family

2005 • 3,637 citations

A microRNA polycistron as a potential human oncogene

2005 • 3,482 citations

miR-15 and miR-16 induce apoptosis by targeting BCL2

2005 • 3,424 citations

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

2006 • 3,029 citations

A microRNA component of the p53 tumour suppressor network

2007 • 2,620 citations

MicroRNA biogenesis: coordinated cropping and dicing

2005 • 2,443 citations

A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia

2005 • 2,391 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

2004 • 2,341 citations

Identification of Mammalian microRNA Host Genes and Transcription Units

2004 • 1,966 citations

Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis

2007 • 1,949 citations

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

2004 • 1,827 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation

2005 • 1,504 citations

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

2000 • 1,307 citations

Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis

2007 • 1,297 citations

MYC oncogenes and human neoplastic disease

1999 • 1,146 citations

Transcriptional regulation and transformation by Myc proteins

2005 • 1,102 citations

Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster

2006 • 1,047 citations

Extensive post-transcriptional regulation of microRNAs and its implications for cancer

2006 • 835 citations

Identification and Characterization of a Novel Gene, C13orf25 , as a Target for 13q31-q32 Amplification in Malignant Lymphoma

2004 • 727 citations

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

2002 • 676 citations

A Hexanucleotide Element Directs MicroRNA Nuclear Import

2007 • 666 citations

Repression of p15INK4b expression by Myc through association with Miz-1

2001 • 571 citations

Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes

1981 • 497 citations

Global mapping of c-Myc binding sites and target gene networks in human B cells

2006 • 493 citations

HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo

2007 • 491 citations

Myc represses the p21 ^(WAF1/CIP1) promoter and interacts with Sp1/Sp3

2001 • 411 citations

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

2003 • 353 citations

Antisense-Mediated Depletion Reveals Essential and Specific Functions of MicroRNAs in Drosophila Development

2005 • 317 citations

The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation

1999 • 316 citations

Activation of Transferrin Receptor 1 by c-Myc Enhances Cellular Proliferation and Tumorigenesis

2006 • 235 citations

Direct Interaction of c-Myc with Smad2 and Smad3 to Inhibit TGF-β-Mediated Induction of the CDK Inhibitor p15Ink4B

2002 • 224 citations

Cell cycle activation by c-myc in a Burkitt lymphoma model cell line

2000 • 203 citations

Analysis of Myc Bound Loci Identified by CpG Island Arrays Shows that Max Is Essential for Myc-Dependent Repression

2003 • 185 citations

Mechanism for the transcriptional repression by c-Myc on PDGF β-receptor

2001 • 101 citations

Mechanisms of Transcriptional Repression by Myc

2006 • 97 citations

Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway

2003 • 60 citations

A non-transgenic mouse model for B-cell lymphoma: in vivo infection of p53-null bone marrow progenitors by a Myc retrovirus is sufficient for tumorigenesis

2002 • 52 citations

Functional Validation of Genes Implicated in Lymphomagenesis: An in Vivo Selection Assay Using a Myc‐Induced B‐Cell Tumor

2005 • 46 citations

Inactivation of Myc in Murine Two-Hit B lymphomas Causes Dormancy with Elevated Levels of Interleukin 10 Receptor and CD20: Implications for Adjuvant Therapies

2005 • 31 citations

Characterization and Differentiation of an Early Murine Yolk Sac-Derived IL-7-Independent Pre-Pro-B Cell Line

1998 • 11 citations

Deleted Work

1955 • 0 citations