miR-21-mediated tumor growth

MicroRNAs

2004 • 33,206 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

2002 • 4,860 citations

Real-time quantification of microRNAs by stem-loop RT-PCR

2005 • 4,707 citations

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

2004 • 4,068 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

MicroRNA Gene Expression Deregulation in Human Breast Cancer

2005 • 4,014 citations

Silencing of microRNAs in vivo with ‘antagomirs’

2005 • 3,846 citations

MicroRNAs Modulate Hematopoietic Lineage Differentiation

2003 • 3,241 citations

MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

2005 • 2,530 citations

MicroRNA biogenesis: coordinated cropping and dicing

2005 • 2,443 citations

Reduced accumulation of specific microRNAs in colorectal neoplasia.

2003 • 1,559 citations

Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis

2005 • 1,421 citations

Accumulation of miR-155 and BIC RNA in human B cell lymphomas

2005 • 1,324 citations

miRNAs, Cancer, and Stem Cell Division

2005 • 1,313 citations

Ribo-gnome: The Big World of Small RNAs

2005 • 1,276 citations

MicroRNA function: Multiple mechanisms for a tiny RNA?: FIGURE 1.

2005 • 676 citations

MicroRNA expression profiling of single whole embryonic stem cells

2006 • 339 citations

Comparison of Topoisomerase I Inhibition, DNA Damage, and Cytotoxicity of Camptothecin Derivatives Presently in Clinical Trials

1994 • 291 citations

Multiplexing RT-PCR for the detection of multiple miRNA species in small samples

2006 • 139 citations

A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model.

2002 • 104 citations

Overexpression of a Dominant-Negative Mutant Ubc9 Is Associated with Increased Sensitivity to Anticancer Drugs

2004 • 71 citations

RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes.

2005 • 25 citations