MicroRNA biogenesis: coordinated cropping and dicing

MicroRNAs

2004 • 33,206 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

The functions of animal microRNAs

2004 • 10,392 citations

Prediction of Mammalian MicroRNA Targets

2003 • 5,070 citations

The nuclear RNase III Drosha initiates microRNA processing

2003 • 4,966 citations

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

2002 • 4,860 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

2000 • 4,834 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

MicroRNA genes are transcribed by RNA polymerase II

2004 • 4,200 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

MicroRNAs Modulate Hematopoietic Lineage Differentiation

2003 • 3,241 citations

Identification of Tissue-Specific MicroRNAs from Mouse

2002 • 3,236 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

2003 • 2,893 citations

Asymmetry in the Assembly of the RNAi Enzyme Complex

2003 • 2,761 citations

Nuclear Export of MicroRNA Precursors

2003 • 2,662 citations

The Microprocessor complex mediates the genesis of microRNAs

2004 • 2,625 citations

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

2001 • 2,623 citations

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

2004 • 2,620 citations

Processing of primary microRNAs by the Microprocessor complex

2004 • 2,617 citations

Functional siRNAs and miRNAs Exhibit Strand Bias

2003 • 2,516 citations

MicroRNA maturation: stepwise processing and subcellular localization

2002 • 2,410 citations

The Drosha-DGCR8 complex in primary microRNA processing

2004 • 2,096 citations

A pancreatic islet-specific microRNA regulates insulin secretion

2004 • 2,054 citations

Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi

2002 • 2,040 citations

bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

2003 • 2,012 citations

Identification of Mammalian microRNA Host Genes and Transcription Units

2004 • 1,966 citations

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

2004 • 1,887 citations

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

2001 • 1,847 citations

A uniform system for microRNA annotation

2003 • 1,841 citations

Regulation of Flowering Time and Floral Organ Identity by a MicroRNA and Its APETALA2-Like Target Genes

2003 • 1,833 citations

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

2004 • 1,827 citations

MicroRNAs in plants

2002 • 1,791 citations

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

2001 • 1,761 citations

MicroRNA-Directed Cleavage of HOXB8 mRNA

2004 • 1,680 citations

Genetic and Functional Diversification of Small RNA Pathways in Plants

2004 • 1,553 citations

Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation

2004 • 1,526 citations

Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

2001 • 1,492 citations

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

2004 • 1,406 citations

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

2004 • 1,406 citations

Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

2004 • 1,370 citations

MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias

2004 • 1,306 citations

Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways

2004 • 1,254 citations

CARPEL FACTORY, a Dicer Homolog, and HEN1, a Novel Protein, Act in microRNA Metabolism in Arabidopsis thaliana

2002 • 1,243 citations

The microRNAs ofCaenorhabditis elegans

2003 • 1,232 citations

Methylation as a Crucial Step in Plant microRNA Biogenesis

2005 • 1,082 citations

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

2002 • 1,081 citations

Unlocking the potential of the human genome with RNA interference

2004 • 1,066 citations

ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation

2003 • 1,041 citations

A microRNA array reveals extensive regulation of microRNAs during brain development

2003 • 1,034 citations

Two classes of short interfering RNA in RNA silencing

2002 • 1,022 citations

MicroRNA-143 Regulates Adipocyte Differentiation

2004 • 1,007 citations

The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism

2003 • 1,003 citations

Single Processing Center Models for Human Dicer and Bacterial RNase III

2004 • 985 citations

The Small RNA Profile during Drosophila melanogaster Development

2003 • 955 citations

An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues

2004 • 942 citations

Arabidopsis micro-RNA biogenesis through Dicer-like 1 protein functions

2004 • 919 citations

Endogenous and Silencing-Associated Small RNAs in Plants[W]

2002 • 908 citations

SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis

2004 • 905 citations

Establishment and Maintenance of a Heterochromatin Domain

2002 • 895 citations

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

2002 • 874 citations

A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegans

2001 • 853 citations

Both Natural and Designed Micro RNAs Can Inhibit the Expression of Cognate mRNAs When Expressed in Human Cells

2002 • 824 citations

The Human DiGeorge Syndrome Critical Region Gene 8 and Its D. melanogaster Homolog Are Required for miRNA Biogenesis

2004 • 815 citations

Endogenous trans-Acting siRNAs Regulate the Accumulation of Arabidopsis mRNAs

2004 • 791 citations

Microarray analysis of microRNA expression in the developing mammalian brain

2004 • 784 citations

A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans

2003 • 756 citations

Transcription and Processing of Human microRNA Precursors

2004 • 752 citations

Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline

2001 • 745 citations

Transport of Proteins and RNAs in and out of the Nucleus

1999 • 741 citations

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

2004 • 717 citations

MicroRNAs and Other Tiny Endogenous RNAs in C. elegans

2003 • 702 citations

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

2003 • 690 citations

Fragile X-related protein and VIG associate with the RNA interference machinery

2002 • 646 citations

Nuclear processing and export of microRNAs in Arabidopsis

2005 • 645 citations

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

2002 • 622 citations

Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

2004 • 604 citations

Analysis of a piwi-Related Gene Implicates Small RNAs in Genome Rearrangement in Tetrahymena

2002 • 594 citations

A Protein Sensor for siRNA Asymmetry

2004 • 584 citations

Regulation of Apoptosis by Alternative Pre-mRNA Splicing

2005 • 582 citations

A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

2002 • 573 citations

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

2003 • 569 citations

MicroRNA expression detected by oligonucleotide microarrays: System establishment and expression profiling in human tissues

2004 • 557 citations

Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha

2004 • 554 citations

Sequence requirements for micro RNA processing and function in human cells

2003 • 538 citations

The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans

2002 • 538 citations

The Nuclear dsRNA Binding Protein HYL1 Is Required for MicroRNA Accumulation and Plant Development, but Not Posttranscriptional Transgene Silencing

2004 • 514 citations

The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation

2004 • 504 citations

Small RNAs Correspond to Centromere Heterochromatic Repeats

2002 • 501 citations

Structural requirements for pre-microRNA binding and nuclear export by Exportin 5

2004 • 476 citations

A high-throughput method to monitor the expression of microRNA precursors

2004 • 475 citations

Structure and conserved RNA binding of the PAZ domain

2003 • 468 citations

Small RNAs: Classification, Biogenesis, and Function

2005 • 465 citations

A Small Modulatory dsRNA Specifies the Fate of Adult Neural Stem Cells

2004 • 440 citations

miRNAs on the move: miRNA biogenesis and the RNAi machinery

2004 • 395 citations

RNAi Related Mechanisms Affect Both Transcriptional and Posttranscriptional Transgene Silencing in Drosophila

2002 • 383 citations

Probing microRNAs with microarrays: Tissue specificity and functional inference

2004 • 375 citations

Evidence for Nuclear Processing of Plant Micro RNA and Short Interfering RNA Precursors

2003 • 365 citations

MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode

2004 • 345 citations

Nucleic acid 3′-end recognition by the Argonaute2 PAZ domain

2004 • 342 citations

Development of a micro-array to detect human and mouse microRNAs and characterization of expression in human organs

2004 • 337 citations

Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity

2003 • 316 citations

Arabidopsis HEN1

2003 • 296 citations

Methylation of Histone H3 at Lysine 9 Targets Programmed DNA Elimination in Tetrahymena

2002 • 290 citations

HASTY, theArabidopsisortholog of exportin 5/MSN5, regulates phase change and morphogenesis

2003 • 282 citations

MicroRNA precursors in motion: exportin-5 mediates their nuclear export

2004 • 273 citations

Overexpression of Exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs

2004 • 272 citations

Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA

2001 • 258 citations

Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm

2002 • 236 citations

Crystallographic and Modeling Studies of RNase III Suggest a Mechanism for Double-Stranded RNA Cleavage

2001 • 230 citations

Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA

2002 • 196 citations

Human RNase III Is a 160-kDa Protein Involved in Preribosomal RNA Processing

2000 • 193 citations

Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification

2004 • 192 citations

Dissection of a Natural RNA Silencing Process in the Drosophila melanogaster Germ Line

2004 • 191 citations

The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter

2003 • 188 citations

RNA interference in Trypanosoma brucei: cloning of small interfering RNAs provides evidence for retroposon-derived 24-26-nucleotide RNAs.

2001 • 178 citations

Trans-splicing and polyadenylation of let-7 microRNA primary transcripts

2004 • 170 citations

Human let-7 stem-loop precursors harbor features of RNase III cleavage products

2003 • 164 citations

Exportin-5 Mediates Nuclear Export of Minihelix-containing RNAs

2003 • 164 citations

Histone H3 lysine 9 methylation is required for DNA elimination in developing macronuclei in Tetrahymena

2004 • 155 citations

HASTY: a gene that regulates the timing of shoot maturation in Arabidopsis thaliana

1998 • 144 citations

A novel type of RNase III family proteins in eukaryotes

2000 • 138 citations

Short RNAs Can Identify New Candidate Transposable Element Families in Arabidopsis

2002 • 138 citations

Use of RNA Polymerase II to Transcribe Artificial MicroRNAs

2005 • 125 citations

Identification and purification of EBP1: a HeLa cell protein that binds to a region overlapping the 'core' of the SV40 enhancer.

1988 • 63 citations

Mouse ribonuclease III. cDNA structure, expression analysis, and chromosomal location

2002 • 42 citations