Oncomirs — microRNAs with a role in cancer

MicroRNAs

2004 • 33,206 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

MicroRNA expression profiles classify human cancers

2005 • 9,457 citations

Prediction of Mammalian MicroRNA Targets

2003 • 5,070 citations

The nuclear RNase III Drosha initiates microRNA processing

2003 • 4,966 citations

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

2002 • 4,860 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

2000 • 4,834 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

2005 • 4,706 citations

Combinatorial microRNA target predictions

2005 • 4,543 citations

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

2004 • 4,068 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

MicroRNA Gene Expression Deregulation in Human Breast Cancer

2005 • 4,014 citations

Silencing of microRNAs in vivo with ‘antagomirs’

2005 • 3,846 citations

Human MicroRNA Targets

2004 • 3,702 citations

RAS Is Regulated by the let-7 MicroRNA Family

2005 • 3,637 citations

A microRNA polycistron as a potential human oncogene

2005 • 3,482 citations

miR-15 and miR-16 induce apoptosis by targeting BCL2

2005 • 3,424 citations

RNA interference

2002 • 3,369 citations

MicroRNAs Modulate Hematopoietic Lineage Differentiation

2003 • 3,241 citations

Identification of Tissue-Specific MicroRNAs from Mouse

2002 • 3,236 citations

MicroRNA targets in Drosophila

2003 • 3,228 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

2003 • 2,893 citations

An Extensive Class of Small RNAs in Caenorhabditis elegans

2001 • 2,806 citations

Asymmetry in the Assembly of the RNAi Enzyme Complex

2003 • 2,761 citations

Nuclear Export of MicroRNA Precursors

2003 • 2,662 citations

The Microprocessor complex mediates the genesis of microRNAs

2004 • 2,625 citations

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

2001 • 2,623 citations

Processing of primary microRNAs by the Microprocessor complex

2004 • 2,617 citations

MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

2005 • 2,530 citations

Functional siRNAs and miRNAs Exhibit Strand Bias

2003 • 2,516 citations

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

2000 • 2,422 citations

MicroRNA maturation: stepwise processing and subcellular localization

2002 • 2,410 citations

A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia

2005 • 2,391 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

Fast and effective prediction of microRNA/target duplexes

2004 • 2,357 citations

Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

2004 • 2,341 citations

Principles of MicroRNA–Target Recognition

2005 • 2,335 citations

A pancreatic islet-specific microRNA regulates insulin secretion

2004 • 2,054 citations

bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

2003 • 2,012 citations

Identification of Mammalian microRNA Host Genes and Transcription Units

2004 • 1,966 citations

Dicer is essential for mouse development

2003 • 1,896 citations

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

2001 • 1,847 citations

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

2004 • 1,827 citations

Identification of hundreds of conserved and nonconserved human microRNAs

2005 • 1,825 citations

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

2001 • 1,761 citations

Control of leaf morphogenesis by microRNAs

2003 • 1,756 citations

MicroRNA-Directed Cleavage of HOXB8 mRNA

2004 • 1,680 citations

Specificity of microRNA target selection in translational repression

2004 • 1,631 citations

Cleavage of Scarecrow-like mRNA Targets Directed by a Class of Arabidopsis miRNA

2002 • 1,569 citations

Reduced accumulation of specific microRNAs in colorectal neoplasia.

2003 • 1,559 citations

Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation

2004 • 1,526 citations

A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation

2005 • 1,504 citations

Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis

2005 • 1,421 citations

Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes

2005 • 1,411 citations

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

2005 • 1,408 citations

Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

2004 • 1,370 citations

Accumulation of miR-155 and BIC RNA in human B cell lymphomas

2005 • 1,324 citations

Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

2005 • 1,311 citations

MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias

2004 • 1,306 citations

MicroRNAs Regulate Brain Morphogenesis in Zebrafish

2005 • 1,287 citations

Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways

2004 • 1,254 citations

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

2005 • 1,253 citations

The microRNAs ofCaenorhabditis elegans

2003 • 1,232 citations

The role of microRNA genes in papillary thyroid carcinoma

2005 • 1,217 citations

Vertebrate MicroRNA Genes

2003 • 1,190 citations

The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation

1999 • 1,174 citations

Sibling rivalry in the E2F family

2002 • 1,158 citations

Extensive modulation of a set of microRNAs in primary glioblastoma

2005 • 1,090 citations

A microRNA array reveals extensive regulation of microRNAs during brain development

2003 • 1,034 citations

MicroRNA-143 Regulates Adipocyte Differentiation

2004 • 1,007 citations

The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism

2003 • 1,003 citations

A biochemical framework for RNA silencing in plants

2003 • 985 citations

The Small RNA Profile during Drosophila melanogaster Development

2003 • 955 citations

An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues

2004 • 942 citations

New microRNAs from mouse and human

2003 • 881 citations

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

2002 • 874 citations

Identification of Drosophila MicroRNA Targets

2003 • 792 citations

Heterochronic Mutants of the Nematode Caenorhabditis elegans

1984 • 792 citations

Microarray analysis of microRNA expression in the developing mammalian brain

2004 • 784 citations

A combined computational-experimental approach predicts human microRNA targets

2004 • 776 citations

MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation

2005 • 762 citations

The lin-41 RBCC Gene Acts in the C. elegans Heterochronic Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription Factor

2000 • 761 citations

A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans

2003 • 756 citations

A custom microarray platform for analysis of microRNA gene expression

2004 • 733 citations

Identification and Characterization of a Novel Gene, C13orf25 , as a Target for 13q31-q32 Amplification in Malignant Lymphoma

2004 • 727 citations

Computational identification of DrosophilamicroRNA genes

2003 • 724 citations

Regulation of miRNA expression during neural cell specification

2005 • 692 citations

BIC and miR‐155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas

2005 • 676 citations

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb

2005 • 639 citations

Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

2002 • 624 citations

Aberrant T cell differentiation in the absence of Dicer

2005 • 620 citations

Microarray-based, high-throughput gene expression profiling of microRNAs

2004 • 618 citations

Reduced expression of Dicer associated with poor prognosis in lung cancer patients

2005 • 586 citations

Sequence requirements for micro RNA processing and function in human cells

2003 • 538 citations

Dicer Is Required for Embryonic Angiogenesis during Mouse Development

2004 • 536 citations

Dicer is essential for formation of the heterochromatin structure in vertebrate cells

2004 • 484 citations

The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR

2004 • 441 citations

MicroRNA profiling of the murine hematopoietic system.

2005 • 428 citations

The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development

2005 • 392 citations

Probing microRNAs with microarrays: Tissue specificity and functional inference

2004 • 375 citations

The Caenorhabditis elegans hunchback-like Gene lin-57/hbl-1 Controls Developmental Time and Is Regulated by MicroRNAs

2003 • 370 citations

The C. elegans hunchback Homolog, hbl-1, Controls Temporal Patterning and Is a Probable MicroRNA Target

2003 • 354 citations

Antisense therapy for cancer

2005 • 353 citations

MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode

2004 • 345 citations

Development of a micro-array to detect human and mouse microRNAs and characterization of expression in human organs

2004 • 337 citations

Depletion of Human Micro-RNA miR-125b Reveals That It Is Critical for the Proliferation of Differentiated Cells but Not for the Down-regulation of Putative Targets during Differentiation

2005 • 336 citations

Control of Developmental Timing by MicroRNAs and Their Targets

2002 • 332 citations

Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity

2003 • 316 citations

Computational identification of microRNA targets

2004 • 308 citations

The microRNA world: small is mighty

2003 • 301 citations

Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas

2002 • 300 citations

bic, a Novel Gene Activated by Proviral Insertions in Avian Leukosis Virus-Induced Lymphomas, Is Likely To Function through Its Noncoding RNA

1997 • 280 citations

The Temporal Patterning MicroRNA let-7 Regulates Several Transcription Factors at the Larval to Adult Transition in C. elegans

2005 • 260 citations

High expression of B‐cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma

2003 • 236 citations

Common logic of transcription factor and microRNA action

2004 • 199 citations

The bantam Gene Regulates Drosophila Growth

2002 • 186 citations

Short interfering RNAs as a tool for cancer gene therapy

2004 • 182 citations

Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events.

1989 • 172 citations

Architecture of a Validated MicroRNA::Target Interaction

2004 • 166 citations

Human let-7 stem-loop precursors harbor features of RNase III cleavage products

2003 • 164 citations

Control of developmental timing in Caenorhabditis elegans

2000 • 152 citations

The Timing oflin-4RNA Accumulation Controls the Timing of Postembryonic Developmental Events inCaenorhabditis elegans

1999 • 148 citations

Loss of heterozygosity at chromosome 13q in hepatocellular carcinoma: identification of three independent regions

1999 • 89 citations

A novel and consistent amplicon at 13q31 associated with alveolar rhabdomyosarcoma

2000 • 83 citations

Gains of 13q are correlated with a poor prognosis in liposarcoma

2004 • 58 citations

Deleted Work

1955 • 0 citations