Emerging roles of thioredoxin cycle enzymes in the central nervous system

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Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

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Coronary Computed Tomography Angiography for Early Triage of Patients With Acute Chest Pain

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Identification of a New Type of Mammalian Peroxiredoxin That Forms an Intramolecular Disulfide as a Reaction Intermediate

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The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice

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Amyotrophic Lateral Sclerosis

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Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

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Essential Role of Selenium in the Catalytic Activities of Mammalian Thioredoxin Reductase Revealed by Characterization of Recombinant Enzymes with Selenocysteine Mutations

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Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice

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Cloning and Expression of a Novel Mammalian Thioredoxin

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Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria

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Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage

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Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis

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Human Thioredoxin Reductase Directly Reduces Lipid Hydroperoxides by NADPH and Selenocystine Strongly Stimulates the Reaction via Catalytically Generated Selenols

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Mice with Targeted Mutation of Peroxiredoxin 6 Develop Normally but Are Susceptible to Oxidative Stress

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Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.

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Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems

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Overexpression of Human Thioredoxin in Transgenic Mice Controls Oxidative Stress and Life Span

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Selenoprotein Metabolism and Function: Evidence for More than One Function for Selenoprotein P

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Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders

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Molecular Cloning and Characterization of a Mitochondrial Selenocysteine-containing Thioredoxin Reductase from Rat Liver

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Mammalian thioredoxin reductase: Oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity

2000 • 264 citations

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2001 • 263 citations

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1997 • 258 citations

Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.

1997 • 244 citations

Regulation of Peroxiredoxin I Activity by Cdc2-mediated Phosphorylation

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Energetics and Oxidative Stress in Synaptic Plasticity and Neurodegenerative Disorders

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Thioredoxin, a Singlet Oxygen Quencher and Hydroxyl Radical Scavenger: Redox Independent Functions

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Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin

1999 • 237 citations

Absolute and Relative Kinetic Changes of High-Sensitivity Cardiac Troponin T in Acute Coronary Syndrome and in Patients with Increased Troponin in the Absence of Acute Coronary Syndrome

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Circulating thioredoxin suppresses lipopolysaccharide-induced neutrophil chemotaxis

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Identification and Functional Characterization of a Novel Mitochondrial Thioredoxin System in Saccharomyces cerevisiae

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Thioredoxin Reductase Activity Is Decreased by Selenium Deficiency

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Overexpression of peroxiredoxin in human breast cancer.

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Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay

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Cloning and sequencing of a human thioredoxin reductase

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Thioredoxin regenerates proteins inactivated by oxidative stress in endothelial cells

1992 • 210 citations

Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis.

2003 • 209 citations

1-Cys peroxiredoxin overexpression protects cells against phospholipid peroxidation-mediated membrane damage

2002 • 208 citations

Increased infarct size and exacerbated apoptosis in the glutathione peroxidase‐1 (Gpx‐1) knockout mouse brain in response to ischemia/reperfusion injury

2001 • 206 citations

Early discharge using single cardiac troponin and copeptin testing in patients with suspected acute coronary syndrome (ACS): a randomized, controlled clinical process study

2014 • 206 citations

Nucleoredoxin, Glutaredoxin, and Thioredoxin Differentially Regulate NF-κB, AP-1, and CREB Activation in HEK293 Cells

2000 • 205 citations

Cyclophilin A Binds to Peroxiredoxins and Activates Its Peroxidase Activity

2001 • 204 citations

Decreased thioredoxin and increased thioredoxin reductase levels in alzheimer’s disease brain

2000 • 203 citations

Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.

2000 • 200 citations

Diagnosis of Myocardial Infarction Using a High-Sensitivity Troponin I 1-Hour Algorithm

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Efficient Reduction of Lipoamide and Lipoic Acid by Mammalian Thioredoxin Reductase

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Human Mitochondrial Thioredoxin

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Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity

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Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma.

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Reduction of the Ascorbyl Free Radical to Ascorbate by Thioredoxin Reductase

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A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins

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Peroxiredoxin IV Is a Secretable Protein with Heparin-Binding Properties under Reduced Conditions

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The Roles of Thioredoxin in Protection against Oxidative Stress-induced Apoptosis in SH-SY5Y Cells

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SP‐22 is a Thioredoxin‐Dependent Peroxide Reductase in Mitochondria

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Overexpressed Human Mitochondrial Thioredoxin Confers Resistance to Oxidant-induced Apoptosis in Human Osteosarcoma Cells

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Immunohistochemical localization of thioredoxin and thioredoxin reductase in adult rats.

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Physical Studies of Conformational Plasticity in a Recombinant Prion Protein

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Identification of a redox-regulated chaperone network

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Improved diagnostic and prognostic performance of a new high-sensitive troponin T assay in patients with acute coronary syndrome

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A Novel Promoter Sequence Is Involved in the Oxidative Stress-Induced Expression of the Adult T-Cell Leukemia-Derived Factor (ADF)/Human Thioredoxin (Trx) Gene

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Coronary CT Angiography for Suspected ACS in the Era of High-Sensitivity Troponins

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Selenium Deficiency Triggering Intractable Seizures

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Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer’s disease and Down Syndrome

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The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): Thioredoxin mRNA is elevated in some human tumors

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Thioredoxin Superfamily and Thioredoxin‐Inducing Agents

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From Cytoprotection to Tumor Suppression: The Multifactorial Role of Peroxiredoxins

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Pag, a Putative Tumor Suppressor, Interacts with the Myc Box II Domain of c-Myc and Selectively Alters Its Biological Function and Target Gene Expression

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Mitochondrial peroxiredoxin‐3 protects hippocampal neurons from excitotoxic injury in vivo

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Cloning of the peroxiredoxin gene family in rats and characterization of the fourth member

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Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas

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Localization of the thioredoxin system in normal rat kidney

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Glutathione peroxidase deficiency and childhood seizures

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Unrecognized Non-Q-Wave Myocardial Infarction: Prevalence and Prognostic Significance in Patients with Suspected Coronary Disease

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Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation

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Enhanced N-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Toxicity in Mice Deficient in CuZn-Superoxide Dismutase or Glutathione Peroxidase

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Thioredoxin as a Neurotrophic Cofactor and an Important Regulator of Neuroprotection

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Differential expression of peroxiredoxin subtypes in human brain cell types

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Comparison of the activities of protein disulphide-isomerase and thioredoxin in catalysing disulphide isomerization in a protein substrate

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Brain-derived neurotrophic factor, behavior, and new directions for the treatment of mental disorders

2003 • 110 citations

Mitochondrial Thioredoxin System

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Timing of aspirin administration as a determinant of survival of patients with acute myocardial infarction treated with thrombolysis

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Critical Roles of Thioredoxin in Nerve Growth Factor-Mediated Signal Transduction and Neurite Outgrowth in PC12 Cells

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Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1‐mediated motor neuron cell death and increase amyotrophic lateral sclerosis‐like transgenic mouse survival

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Identification of a Novel Thioredoxin-related Transmembrane Protein

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Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin.

1996 • 103 citations

Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors

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Heterogeneity within Animal Thioredoxin Reductases

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Murine Thioredoxin Peroxidase Delays Neuronal Apoptosis and Is Expressed in Areas of the Brain Most Susceptible to Hypoxic and Ischemic Injury

1997 • 98 citations

Protection of methamphetamine nigrostriatal toxicity by dietary selenium

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Absolute Gene Expression Patterns of Thioredoxin and Glutaredoxin Redox Systems in Mouse

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Recombinant peroxiredoxin 5 protects against excitotoxic brain lesions in newborn mice

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Characterization of Human Thioredoxin-like 2

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Neuroprotection by glial cells through adult T cell leukemia-derived factor/human thioredoxin (ADF/TRX)

1994 • 93 citations

The Drosophila Carbonyl Reductase Sniffer Prevents Oxidative Stress-Induced Neurodegeneration

2004 • 86 citations

Mitochondrial and Cytoplasmic Thioredoxin Reductase Variants Encoded by a Single Drosophila Gene Are Both Essential for Viability

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Thioredoxin reductase and glutathione synthesis is upregulated byt-butylhydroquinone in cortical astrocytes but not in cortical neurons

2000 • 82 citations

Transactivation of an inducible anti-oxidative stress protein, human thioredoxin by HTLV-I Tax

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Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine

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Redox Control of Neuronal Damage during Brain Ischemia after Middle Cerebral Artery Occlusion in the Rat: Immunohistochemical and Hybridization Studies of Thioredoxin

1998 • 79 citations

Mitochondrial thioredoxin reductase in bovine adrenal cortex

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Function of Thioredoxin Reductase as a Peroxynitrite Reductase Using Selenocystine or Ebselen

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Selenium-containing proteins in mammals and other forms of life

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Localization of thioredoxin in the rat brain and functional implications

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Thioredoxin suppresses 1-methyl-4-phenylpyridinium-induced neurotoxicity in rat PC12 cells

2002 • 73 citations

A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeastSchizosaccharomyces pombe

1996 • 71 citations

Immunocytochemical localization of seleno-glutathione peroxidase in the adult mouse brain

1996 • 70 citations

Expression of Antioxidant Enzymes in Astrocytic Brain Tumors

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Overexpression of thioredoxin reductase 1 regulates NF‐κB activation

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Expression of novel antioxidant thioredoxin‐2 in the rat brain

2000 • 68 citations

Upregulation of the Genes Encoding Lysosomal Hydrolases, a Perforin-Like Protein, and Peroxidases in the Brains of Mice Affected with an Experimental Prion Disease

2000 • 67 citations

A thioredoxin — Thioredoxin reductase system from rat tumor

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Astroglial expression of ATL-derived factor, a human thioredoxin homologue, in the gerbil brain after transient global ischemia

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The impact of hs C-reactive protein and other inflammatory biomarkers on long-term cardiovascular mortality in patients with acute coronary syndromes

2006 • 64 citations

Overexpression of Enzymatically Active Human Cytosolic and Mitochondrial Thioredoxin Reductase in HEK-293 Cells

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Glutathione peroxidase inhibits cell death and glial activation following experimental stroke

2002 • 63 citations

Genomic cloning of human thioredoxin-encoding gene: mapping of the transcription start point and analysis of the promoter

1994 • 63 citations

Proteomic comparison between human young and old brains by two‐dimensional gel electrophoresis and identification of proteins

2003 • 60 citations

Release Kinetics of Inflammatory Biomarkers in a Clinical Model of Acute Myocardial Infarction

2014 • 59 citations

Co-induction of heme oxygenase-1 and peroxiredoxin I in astrocytes and microglia around hemorrhagic region in the rat brain

2000 • 55 citations

Induction of Antioxidative and Antiapoptotic Thioredoxin Supports Neuroprotective Hypothesis of Estrogen

2003 • 55 citations

The pag gene product, a physiological inhibitor of c‐abl tyrosine kinase, is overexpressed in cells entering S phase and by contact with agents inducing oxidative stress

1998 • 53 citations

Expression and distribution of redox regulatory protein, thioredoxin during transient focal brain ischemia in the rat

1998 • 53 citations

Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system

2000 • 50 citations

Impairment of synaptic transmission by transient hypoxia in hippocampal slices: Improved recovery in glutathione peroxidase transgenic mice

2000 • 46 citations

Axoplasmic transport of thioredoxin and thioredoxin reductase in rat sciatic nerve

1985 • 44 citations

Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition

2004 • 43 citations

cDNA cloning, expression and chromosomal localization of the mouse mitochondrial thioredoxin reductase gene

1999 • 43 citations

Release Kinetics of Copeptin in Patients Undergoing Transcoronary Ablation of Septal Hypertrophy

2013 • 42 citations

Release Kinetics of Cardiac Biomarkers in Patients Undergoing Transcoronary Ablation of Septal Hypertrophy

2012 • 40 citations

Histological evidence of redox system breakdown caused by superoxide dismutase 1 (SOD1) aggregation is common to SOD1-mutated motor neurons in humans and animal models

2004 • 38 citations

Transgenic Glutathione Peroxidase Mouse Models for Neuroprotection Studies^a

1994 • 38 citations

Thioredoxin from Activated Macrophages as a Trophic Factor for Central Cholinergic Neurons in Vitro

1993 • 36 citations

Excitotoxic Hippocampal Injury is Attenuated in Thioredoxin Transgenic Mice

2000 • 34 citations

Involvement of thiol transferase- and thioredoxin-dependent systems in the protection of ‘essential’ thiol groups of ornithine decarboxylase

1989 • 32 citations

Altered gene expressions during hypoxia and reoxygenation in cortical neurons isolated from stroke-prone spontaneously hypertensive rats

2000 • 32 citations

Kinetic characteristics of a thioredoxin-activated rat hepatic and renal low-Km iodothyronine 5′-deiodinase

1989 • 31 citations

Hypoxia-ischemia induces thioredoxin expression and nitrotyrosine formation in new-born rat brain

2002 • 31 citations

Presenilin-1 Protects against Neuronal Apoptosis Caused by Its Interacting Protein PAG

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Up-regulation of thioredoxin expression in motor neurons after nerve injury

1998 • 30 citations

Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons

2002 • 29 citations

Lens-Specific Regulation of the Thioredoxin-1 Gene, but Not Thioredoxin-2, upon in Vivo Photochemical Oxidative Stress in the Emory Mouse

1999 • 29 citations

Signal transduction and regulation of neurotrophins

1992 • 26 citations

Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non‐desensitizing AMPA receptors in hippocampal cultures

2003 • 24 citations

Molecular cloning of mouse thioredoxin reductases

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Midlife Cardiovascular Risk Factors and Late‐Life Unrecognized and Recognized Myocardial Infarction Detect by Cardiac Magnetic Resonance: ICELAND‐MI, the AGES‐Reykjavik Study

2016 • 22 citations

High-sensitivity cardiac troponin T and copeptin assays to improve diagnostic accuracy of exercise stress test in patients with suspected coronary artery disease

2014 • 21 citations

Expression and distribution of redox regulatory protein, thioredoxin after metabolic impairment by 3-nitropropionic acid in rat brain

1999 • 20 citations

Thioredoxin converts the Syrian hamster (29-231) recombinant prion protein to an insoluble form

2001 • 19 citations

Identification of acute myocardial infarction in patients with atrial fibrillation and chest pain with a contemporary sensitive troponin I assay

2015 • 19 citations

Effects of kainate-mediated excitotoxicity on the expression of rat counterparts of A170 and MSP23 stress proteins in the brain

1999 • 18 citations

Expression of Adult T Cell Leukemia-Derived Factor in Human Brain and Peripheral Nerve Tissues

1998 • 12 citations