Transgenic Glutathione Peroxidase Mouse Models for Neuroprotection Studies^a

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Free radicals, antioxidants, and human disease: where are we now?

1992 • 2,223 citations

The aging process.

1981 • 1,871 citations

Free Radicals as Mediators of Tissue Injury and Disease

1993 • 1,480 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Age-related changes in oxidized proteins.

1987 • 1,229 citations

Oxidative Stress: Oxidants and Antioxidants.

1992 • 1,193 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it

1992 • 925 citations

Role of oxygen free radicals in carcinogenesis and brain ischemia

1990 • 885 citations

Molecular Biology of Aging

1999 • 877 citations

Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

1984 • 729 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides.

1990 • 516 citations

Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

1991 • 516 citations

Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed gene

1982 • 464 citations

Glutathione peroxidase, glial cells and Parkinson's disease

1993 • 448 citations

Metallothioneins: Proteins in search of function

1985 • 445 citations

Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis.

1989 • 380 citations

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.

1992 • 344 citations

Endogenous DNA damage as related to cancer and aging

1989 • 323 citations

Free radicals in aging

1988 • 314 citations

Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene

1992 • 313 citations

Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures.

1990 • 299 citations

Oxidants Are a Major Contributor to Aginga

1992 • 296 citations

Antioxidants, Aging, and Longevity

1984 • 279 citations

Glutathione Peroxidase Brought into Focus

1982 • 267 citations

Endotoxin induction of murine metallothionein gene expression.

1990 • 239 citations

Contributory mechanisms in the causation of neurodegenerative disorders

1993 • 228 citations

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.

1986 • 215 citations

Involvement of free radicals in dementia of the Alzheimer type: A hypothesis

1990 • 191 citations

Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism.

1993 • 177 citations

Metallothionein gene expression is regulated by serum factors and activators of protein kinase C.

1987 • 156 citations

Effects of Cu-Zn Superoxide Dismutase Overexpression on Life Span and Resistance to Oxidative Stress in Transgenic Drosophila melanogaster

1993 • 156 citations

Hydroxyl Radicals, Iron, Oxidative Stress, and Neurodegeneration^a

1994 • 141 citations

Relationship between Antioxidants, Prooxidants, and the Aging Processa

1992 • 124 citations

In Vivo Generation of Hydroxyl Radicals and MPTP‐Induced Dopaminergic Toxicity in the Basal Ganglia

1994 • 118 citations

Overexpression of seleno-glutathione peroxidase by gene transfer enhances the resistance of T47D human breast cells to clastogenic oxidants.

1991 • 104 citations

Regulation of heme oxygenase and metallothionein gene expression by the heme analogs, cobalt-, and tin-protoporphyrin.

1993 • 84 citations

Heme-hemopexin-mediated induction of metallothionein gene expression.

1992 • 78 citations

Superoxide Dismutase Therapy for Myocardial Ischemia

1991 • 63 citations

Molecular Biology of Aging

1994 • 60 citations

Tissue specific induction of metallothionein synthesis by tumor necrosis factor-alpha.

1992 • 60 citations

The Role of Metal Ions in Oxidative Processes and Aging

1993 • 59 citations

Demential syndromes and the lipid metabolism

2009 • 50 citations

SOD‐1 Transgenic Mice as a Model for Studies of Neuroprotection in Stroke and Brain Trauma^a

1994 • 40 citations

Direct Detection of Radical Production in the Ischaemic and Reperfused Myocardium: Current Status

1989 • 32 citations

Distinct oxidoresistance phenotype of human T47D cells transfected by rat glutathione S-transferase Yc expression vectors.

1992 • 23 citations

Environment, Genetics and Idiopathic Parkinson's Disease

1991 • 23 citations

Association of Antioxidant Systems in the Protection of Human Fibroblasts Against Oxygen Derived Free Radicals

1991 • 22 citations