The role of the redox protein thioredoxin in cell growth and cancer

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Gene Expression Profiles in Normal and Cancer Cells

1997 • 1,157 citations

Enzymatic Synthesis of Deoxyribonucleotides

1964 • 917 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

RIBONUCLEOTIDE REDUCTASES

1998 • 657 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Crystal structure of thioredoxin from Escherichia coli at 1.68 Å resolution

1990 • 568 citations

Structure of NF-κB p50 homodimer bound to a κB site

1995 • 564 citations

Early Embryonic Lethality Caused by Targeted Disruption of the Mouse Thioredoxin Gene

1996 • 529 citations

Structure of the NF-κB p50 homodimer bound to DNA

1995 • 525 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.

1996 • 471 citations

Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway.

1992 • 463 citations

Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution.

1975 • 435 citations

Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide

1995 • 430 citations

Cloning and Expression of a Novel Mammalian Thioredoxin

1997 • 391 citations

Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer

1996 • 376 citations

Structural and functional relations among thioredoxins of different species

1991 • 363 citations

The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase.

1994 • 361 citations

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.

1994 • 351 citations

Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.

1996 • 309 citations

Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin.

1983 • 309 citations

Adult T-cell leukemia-derived factor/thioredoxin, produced by both human T-lymphotropic virus type I- and Epstein-Barr virus-transformed lymphocytes, acts as an autocrine growth factor and synergizes with interleukin 1 and interleukin 2.

1990 • 283 citations

Molecular Cloning and Characterization of a Mitochondrial Selenocysteine-containing Thioredoxin Reductase from Rat Liver

1999 • 277 citations

Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1

1994 • 274 citations

High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin

1994 • 261 citations

Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue

1998 • 261 citations

転写因子NF‐κBとAP‐1の活性化に及ぼすチオレドキシンと抗酸化剤の異なった効果

1994 • 259 citations

Redox signalling and the control of cell growth and death

1995 • 256 citations

Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.

1997 • 244 citations

Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide.

1995 • 240 citations

Cloning and expression of a cDNA for human thioredoxin.

1988 • 239 citations

Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFκB

1995 • 224 citations

The effect of H2O2 upon thioredoxin-enriched lens epithelial cells.

1988 • 214 citations

Cloning and sequencing of a human thioredoxin reductase

1995 • 211 citations

Elevation of plasma thioredoxin levels in HIV-infected individuals

1996 • 209 citations

Direct Association with Thioredoxin Allows Redox Regulation of Glucocorticoid Receptor Function

1999 • 205 citations

Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity.

1996 • 203 citations

Thioredoxin, a putative oncogene product,is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival

2000 • 192 citations

A Genetic Tool Used to Identify Thioredoxin as a Mediator of a Growth Inhibitory Signal

1991 • 189 citations

Human mitochondrial thioredoxin reductase

1999 • 178 citations

Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system.

1996 • 170 citations

Thioredoxin as a potent costimulus of cytokine expression.

1996 • 166 citations

Mutagenesis of structural half-cystine residues in human thioredoxin and effects on the regulation of activity by selenodiglutathione

1993 • 162 citations

Tissue distribution and subcellular localization of bovine thioredoxin determined by radioimmunoassay

1978 • 150 citations

Cell growth stimulation by the redox protein thioredoxin occurs by a novel helper mechanism.

1995 • 147 citations

Expression and growth-promoting effect of adult t-cell leukemia-derived factor a human thioredoxin homologue in hepatocellular carcinoma

1992 • 145 citations

Membrane phospholipid metabolism and signal transduction for protein phosphorylation.

1984 • 143 citations

The high-resolution three-dimensional solution structures of the oxidized and reduced states of human thioredoxin

1994 • 143 citations

Elevation of Manganese Superoxide Dismutase Gene Expression by Thioredoxin

1997 • 143 citations

The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): Thioredoxin mRNA is elevated in some human tumors

1994 • 141 citations

Measurements of Plasma Glutaredoxin and Thioredoxin in Healthy Volunteers and During Open-Heart Surgery

1998 • 126 citations

Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state.

1997 • 126 citations

Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis

1998 • 125 citations

Redox Signaling and the Control of Cell Growth and Death

1996 • 120 citations

Site-directed mutagenesis of active site cysteines in human thioredoxin produces competitive inhibitors of human thioredoxin reductase and elimination of mitogenic properties of thioredoxin.

1994 • 120 citations

Secretion of thioredoxin after in vitro activation of human B cells.

1992 • 116 citations

Early changes in inositol lipids and their metabolites induced by platelet-derived growth factor in quiescent Swiss mouse 3T3 cells

1985 • 114 citations

Cloning, sequencing and functional expression of a novel human thioredoxin reductase

1999 • 113 citations

A CD4⁺ T cell line-secreted factor, growth promoting for normal and leukemic B cells, identified as thioredoxin

1995 • 105 citations

Epstein-Barr virus-containing B-cell line produces an interleukin 1 that it uses as a growth factor.

1987 • 105 citations

Coexpression of adult T-cell leukemia-derived factor, a human thioredoxin homologue, and human papillomavirus DNA in neoplastic cervical squamous epithelium

1991 • 104 citations

Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin.

1996 • 103 citations

Elevated serum level of thioredoxin in patients with hepatocellular carcinoma.

1998 • 94 citations

Neuroprotection by glial cells through adult T cell leukemia-derived factor/human thioredoxin (ADF/TRX)

1994 • 93 citations

IL-2 receptor(p55)/Tac-inducing factor. Purification and characterization of adult T cell leukemia-derived factor.

1988 • 90 citations

Redox manipulation of DNA binding activity and BuGR epitope reactivity of the glucocorticoid receptor

1991 • 90 citations

High rates of thioredoxin secretion correlate with growth arrest in hepatoma cells.

1995 • 89 citations

Purification, Molecular Cloning, and Characterization of TRP32, a Novel Thioredoxin-related Mammalian Protein of 32 kDa

1998 • 87 citations

Nitric oxide-induced inhibition of lung endothelial cell nitric oxide synthase via interaction with allosteric thiols: role of thioredoxin in regulation of catalytic activity.

1996 • 84 citations

Human Thioredoxin Homodimers: Regulation by pH, Role of Aspartate 60, and Crystal Structure of the Aspartate 60 → Asparagine Mutant^,

1997 • 83 citations

Transactivation of an inducible anti-oxidative stress protein, human thioredoxin by HTLV-I Tax

1996 • 82 citations

Interleukin Iβ and thioredoxin are secreted through a novel pathway of secretion

1991 • 80 citations

Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors.

1992 • 77 citations

Molecular Cloning and Characterization of the Mouse Apoptosis Signal-Regulating Kinase 1

1997 • 72 citations

Selenium and the thioredoxin redox system: effects on cell growth and death.

1997 • 71 citations

Oxidative inactivation of thioredoxin as a cellular growth factor and protection by a Cys73 → Ser mutation

1996 • 69 citations

Superoxide dismutase and thioredoxin restore defective p34cdc2 kinase activation in mouse two-cell block

1993 • 68 citations

A thioredoxin — Thioredoxin reductase system from rat tumor

1967 • 65 citations

Mechanism-based inhibition of thioredoxin reductase by antitumor quinoid compounds

1992 • 64 citations

Genomic cloning of human thioredoxin-encoding gene: mapping of the transcription start point and analysis of the promoter

1994 • 63 citations

Human eosinophil cytotoxicity-enhancing factor. Eosinophil-stimulating and dithiol reductase activities of biosynthetic (recombinant) species with COOH-terminal deletions.

1993 • 62 citations

Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines.

1996 • 61 citations

Nuclear factor kappaB transactivation is increased but is not involved in the proliferative effects of thioredoxin overexpression in MCF-7 breast cancer cells.

1999 • 60 citations

Molecular Cloning and Expression of a cDNA Encoding a Human Thioredoxin-like Protein

1998 • 60 citations

Possible Roles of an Adult T-Cell Leukemia (ATL)-Derived Factor/Thioredoxin in the Drug Resistance of ATL to Adriamycin

1997 • 59 citations

Redox Modulation of AP-2 DNA Binding Activityin Vitro

1998 • 58 citations

Identification of molecules involved in the 'early pregnancy factor' phenomenon

1991 • 57 citations

The interplay of nitric oxide and peroxynitrite with signal transduction pathways: Implications for disease

1997 • 55 citations

Inhibition of cellular thioredoxin reductase by diaziquone and doxorubicin. Relationship to the inhibition of cell proliferation and decreased ribonucleotide reductase activity.

1992 • 51 citations

Expression of the v-rel oncogene in reticuloendotheliosis virus-transformed fibroblasts

1988 • 50 citations

Identification of a thioredoxin — related protein associated with plasma membranes

1991 • 50 citations

Cell line-directed screening assay for inhibitors of thioredoxin reductase signaling as potential anti-cancer drugs.

1997 • 48 citations

Human eosinophil cytotoxicity-enhancing factor. II. Multiple forms synthesized by U937 cells and their relationship to thioredoxin/adult T cell leukemia-derived factor.

1991 • 46 citations

Immunohistochemical localization of adult T-cell leukaemia-derived factor, a human thioredoxin homologue, in human fetal tissues

1991 • 46 citations

Early Pregnancy Factor

1992 • 44 citations

Thioredoxin overexpression prevents NO-induced reduction of NO synthase activity in lung endothelial cells

1998 • 43 citations

Human Thioredoxin Reductase Gene Localization to Chromosomal Position 12q23–q24.1 and mRNA Distribution in Human Tissue

1996 • 40 citations

Properties of a thioredoxin purified from rabbit bone marrow which fails to serve as a hydrogen donor for the homologous ribonucleotide reductase.

1983 • 34 citations

Sensitive enzyme-linked immunosorbent assay for adult T-cell leukemia-derived factor and normal value measurement

1996 • 33 citations

Immunohistochemical Distribution of Adult T-Cell Leukemia-Derived Factor/Thioredoxin in Epithelial Components of Normal and Pathologic Human Skin Conditions

1992 • 32 citations

Nuclear transport factors: function, behavior and interaction.

1998 • 27 citations

Reversible inhibition of human thioredoxin reductase activity by cytotoxic alkyl 2-imidazolyl disulfide analogues

1994 • 26 citations

Thioredoxin, a mediator of growth inhibition, maps to 9q31

1995 • 25 citations

Detection of thioredoxin in human serum and biological samples using a sensitive sandwich ELISA with digoxigenin-labeled antibody

1998 • 20 citations

Overexpression of thioredoxin does not confer resistance to cisplatin in transfected human ovarian and colon cancer cell lines

1997 • 20 citations

Is human thioredoxin monomeric or dimeric?

1999 • 19 citations

Alternative forms of the human thioredoxin mRNA: identification and characterization

1996 • 18 citations

Structure of the mouse thioredoxin-encoding gene and its processed pseudogene

1995 • 13 citations

Induction and Function of FcεRII on YT Cells; Possible Role of ADF/Thioredoxin in FcεRII Expression

1992 • 12 citations