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Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons

Data up to Jan 2025

Published2002
Citations29
References41

Total Citations Per Year

Abstract

References (41)

Aggresomes: A Cellular Response to Misfolded Proteins

1998 • 2,116 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

Cellular Defenses against Unfolded Proteins

2001 • 979 citations

Impaired Proteasome Function in Alzheimer's Disease

2000 • 795 citations

Heat Shock Proteins: Endogenous Modulators of Apoptotic Cell Death

2001 • 781 citations

Failure of the ubiquitin–proteasome system in Parkinson's disease

2001 • 508 citations

The protein disulphide-isomerase family: unravelling a string of folds

1999 • 504 citations

Stress management – heat shock protein-70 and the regulation of apoptosis

2001 • 428 citations

Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro.

1996 • 420 citations

Motor Neurons Are Selectively Vulnerable to AMPA/Kainate Receptor-Mediated InjuryIn Vitro

1996 • 368 citations

Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage

1999 • 337 citations

Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa

1996 • 330 citations

Inhibition of the ubiquitin-proteasome system in Alzheimer's disease

2000 • 330 citations

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

2000 • 288 citations

Defective ubiquitination of cerebral proteins in Alzheimer's disease

2000 • 216 citations

Reactive oxygen-reducing and protein-refolding activities of adult t cell leukemia-derived factor /human thioredoxin

1992 • 176 citations

Redox Regulation of Caspase-3(-like) Protease Activity: Regulatory Roles of Thioredoxin and Cytochromec

1998 • 174 citations

Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: Synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases

1999 • 146 citations

Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide production

2001 • 136 citations

Motor neurons are rich in non-phosphorylated neurofilaments: cross-species comparison and alterations in ALS

2000 • 123 citations

Detection of Noncarboxymethyllysine and Carboxymethyllysine Advanced Glycation End Products (AGE) in Serum of Diabetic Patients

1999 • 120 citations

Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease.

1997 • 113 citations

The Selective Toxicity of 1-Methyl-4-phenylpyridinium to Dopaminergic Neurons: The Role of Mitochondrial Complex I and Reactive Oxygen Species Revisited

2000 • 102 citations

Antiulcer effect of geranylgeranylacetone, a new acyclic polyisoprenoid on experimentally induced gastric and duodenal ulcers in rats.

1981 • 94 citations

Protein Aging by Carboxymethylation of Lysines Generates Sites for Divalent Metal and Redox Active Copper Binding: Relevance to Diseases of Glycoxidative Stress

1999 • 86 citations

Geranylgeranylacetone Enhances Expression of Thioredoxin and Suppresses Ethanol-Induced Cytotoxicity in Cultured Hepatocytes

2000 • 85 citations

In vitro kainate injury to large, SMI-32(+) spinal neurons is Ca2+ dependent

1995 • 77 citations

Selective vulnerability of spinal motor neurons to reactive dicarbonyl compounds, intermediate products of glycation, in vitro: implication of inefficient glutathione system in spinal motor neurons

2000 • 63 citations

Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone

1987 • 62 citations

Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death

2000 • 53 citations

Protection against Alcohol-Induced Gastric Mucosal Injury by Geranylgeranylacetone: Effect of Indomethacin

1988 • 38 citations

Advanced glycation endproducts are deposited in neuronal hyaline inclusions: a study on familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation

1999 • 36 citations

Conversion of Lysine to Nϵ-(Carboxymethyl)lysine Increases Susceptibility of Proteins to Metal-Catalyzed Oxidation

1999 • 35 citations

Geranylgeranylacetone induces heat shock protein-73 in rat small intestine

1999 • 32 citations

Accumulation of phosphorylated neurofilaments and increase in apoptosis-specific protein and phosphorylated c-Jun induced by proteasome inhibitors

2000 • 30 citations

The dynamics of chromatin condensation: redistribution of topoisomerase II in the 87A7 heat shock locus during induction and recovery.

1993 • 29 citations

PORTAL HAEMODYNAMICS AND HEPATIC BLOOD FLOW

1996 • 15 citations

The role of protein ubiquitination in neurodegenerative disease.

1991 • 11 citations

Induction of heat shock protein-70 (hsp-70) by intraarterial administration of geranylgeranylacetone

2000 • 10 citations

Effects of a gastric mucosal protecting agent in rats with liver cirrhosis

1992 • 9 citations

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Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in… (2002) – Journal of Neuroscience Research | Metascience Observatory Explorer