Overexpressed Human Mitochondrial Thioredoxin Confers Resistance to Oxidant-induced Apoptosis in Human Osteosarcoma Cells

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.

2001 • 2,603 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Death Signal-induced Localization of p53 Protein to Mitochondria

2000 • 883 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

2000 • 533 citations

Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells

1999 • 518 citations

Identification of a New Type of Mammalian Peroxiredoxin That Forms an Intramolecular Disulfide as a Reaction Intermediate

2000 • 459 citations

The Mitochondrial Permeability Transition, Release of Cytochrome c and Cell Death

2001 • 454 citations

The role of the redox protein thioredoxin in cell growth and cancer

2000 • 443 citations

Properties and Biological Activities of Thioredoxins

2001 • 437 citations

Cloning and Expression of a Novel Mammalian Thioredoxin

1997 • 391 citations

Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis

2002 • 321 citations

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

2000 • 286 citations

Molecular Cloning and Characterization of a Mitochondrial Selenocysteine-containing Thioredoxin Reductase from Rat Liver

1999 • 277 citations

Identification and characterization of a mitochondrial thioredoxin system in plants

2001 • 265 citations

Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.

1997 • 244 citations

The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

2001 • 241 citations

Identification and Functional Characterization of a Novel Mitochondrial Thioredoxin System in Saccharomyces cerevisiae

1999 • 223 citations

Induction of the Mitochondrial Permeability Transition Causes Release of the Apoptogenic Factor Cytochrome c

1998 • 216 citations

A new sensitive assay for the measurement of hydroperoxides

1976 • 200 citations

Human mitochondrial thioredoxin reductase

1999 • 178 citations

SP‐22 is a Thioredoxin‐Dependent Peroxide Reductase in Mitochondria

1997 • 159 citations

Cloning, Expression, and Characterization of a NovelEscherichia coli Thioredoxin

1997 • 148 citations

Progress on the mitochondrial permeability transition pore: regulation by complex I and ubiquinone analogs.

1999 • 144 citations

Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase

2001 • 111 citations

The Cyclosporin A-sensitive Nuclear Factor of Activated T Cells (NFAT) Proteins Are Expressed in Vascular Smooth Muscle Cells

1998 • 102 citations

Selective depletion of mitochondrial glutathione concentrations by (R,S)-3-hydroxy-4-pentenoate potentiates oxidative cell death

1993 • 87 citations

Oxidant-induced apoptosis in cultured human retinal pigment epithelial cells.

1999 • 80 citations

Animal and plant mitochondria contain specific thioredoxins

1989 • 76 citations

Proton Selective Substate of the Mitochondrial Permeability Transition Pore: Regulation by the Redox State of the Electron Transport Chain

1998 • 76 citations

Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase

2001 • 71 citations

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