Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system

The Fas Death Factor

1995 • 4,070 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

IRF Family of Transcription Factors as Regulators of Host Defense

2001 • 1,566 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

2000 • 1,307 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

2001 • 1,020 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses

2002 • 884 citations

Oxidative stress and nuclear factor-κB activation

2000 • 865 citations

Glucocorticoids in T Cell Development and Function

2000 • 783 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

Role of redox potential and reactive oxygen species in stress signaling

1999 • 695 citations

Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein

1995 • 581 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

FasGene Mutations in the Canale–Smith Syndrome, an Inherited Lymphoproliferative Disorder Associated with Autoimmunity

1996 • 486 citations

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.

1996 • 473 citations

Activation interferes with the APO-1 pathway in mature human T cells

1993 • 466 citations

Immune escape of tumors: apoptosis resistance and tumor counterattack

2002 • 453 citations

The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience

1999 • 445 citations

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1995 • 438 citations

NF-κB as a primary regulator of the stress response

1999 • 407 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

Cysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones

2001 • 388 citations

The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.

1999 • 381 citations

Ethnobotany and its role in drug development

2000 • 373 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

The Role of Metabolism in the Antioxidant Function of Vitamin E

1993 • 352 citations

Protein Kinase Cθ in T Cell Activation

2002 • 351 citations

Signaling Networks That Link Cell Proliferation and Cell Fate

2002 • 339 citations

The Antiinflammatory Sesquiterpene Lactone Parthenolide Inhibits NF-κB by Targeting the IκB Kinase Complex

1999 • 336 citations

The Fas Counterattack In Vivo: Apoptotic Depletion of Tumor-Infiltrating Lymphocytes Associated with Fas Ligand Expression by Human Esophageal Carcinoma

1998 • 331 citations

Differential ability of T_h1 and T_h2 T cells to express Fas ligand and to undergo activation-induced cell death

1994 • 329 citations

Sesquiterpene Lactones Specifically Inhibit Activation of NF-κB by Preventing the Degradation of IκB-α and IκB-β

1998 • 325 citations

Somatic Fas Mutations in Non-Hodgkin’s Lymphoma: Association With Extranodal Disease and Autoimmunity

1998 • 324 citations

Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription.

1997 • 320 citations

Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.

1990 • 319 citations

Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell

2000 • 319 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

Inhibition of AP-1 by the Glucocorticoid-inducible Protein GILZ

2001 • 293 citations

The role of Fas ligand in immune privilege

2001 • 276 citations

Molecular mechanisms of activated T cell death in vivo

2002 • 276 citations

Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)

1995 • 273 citations

Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1

1999 • 266 citations

Nuclear Hormone Receptors in T Lymphocytes

2002 • 260 citations

Expression of Fas ligand in liver metastases of human colonic adenocarcinomas

1997 • 259 citations

Regulation of Fas-Ligand Expression during Activation-induced Cell Death in T Lymphocytes via Nuclear Factor κB

1999 • 257 citations

ETHNOPHARMACOLOGY OF MEXICAN ASTERACEAE (COMPOSITAE)

1998 • 245 citations

Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer

1999 • 240 citations

The c-Jun N-Terminal Kinase Cascade Plays a Role in Stress-Induced Apoptosis in Jurkat Cells by Up-Regulating Fas Ligand Expression

1998 • 238 citations

RORγt, a Novel Isoform of an Orphan Receptor, Negatively Regulates Fas Ligand Expression and IL-2 Production in T Cells

1998 • 235 citations

Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids.

1995 • 230 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 228 citations

Transcriptional regulation by cyclic AMP-responsive factors

2000 • 228 citations

Two NFAT Transcription Factor Binding Sites Participate in the Regulation of CD95 (Fas) Ligand Expression in Activated Human T Cells

1997 • 222 citations

Cytotoxic drugs and the CD95 pathway

1999 • 212 citations

Apoptosis signaling in lymphocytes

1999 • 212 citations

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2.

1996 • 211 citations

Antagonism between Nur77 and Glucocorticoid Receptor for Control of Transcription

1997 • 199 citations

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

1995 • 197 citations

Ca2+-dependent Gene Expression Mediated by MEF2 Transcription Factors

2000 • 196 citations

Stress-Induced Fas Ligand Expression in T Cells Is Mediated through a MEK Kinase 1-Regulated Response Element in the Fas Ligand Promoter

1998 • 193 citations

Antioxidant status and lipid peroxidation in patients infected with HIV

1994 • 191 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 183 citations

Transforming Growth Factor β1 Inhibits Fas Ligand Expression and Subsequent Activation-induced Cell Death in T Cells via Downregulation of c-Myc

1999 • 177 citations

High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children [letter]

1994 • 174 citations

Sequential Involvement of NFAT and Egr Transcription Factors in FasL Regulation

2000 • 167 citations

Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events.

1997 • 167 citations

Cyclosporin A-Sensitive Transcription Factor Egr-3 Regulates Fas Ligand Expression

1998 • 164 citations

Role of Fas Ligand and Receptor in the Mechanism of T-Cell Depletion in Acquired Immunodeficiency Syndrome: Effect on CD4+ Lymphocyte Depletion and Human Immunodeficiency Virus Replication

1997 • 159 citations

Transcriptional Regulation of the Human FasL Promoter-Enhancer Region

1998 • 156 citations

Cabin1 Represses MEF2-Dependent Nur77 Expression and T Cell Apoptosis by Controlling Association of Histone Deacetylases and Acetylases with MEF2

2000 • 156 citations

Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-co-stimulated human T cells

2000 • 153 citations

Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children

1996 • 150 citations

Feverfew for preventing migraine

2015 • 147 citations

Bcl-2–Mediated Drug Resistance

1999 • 147 citations

Vitamin E and immunity

2000 • 144 citations

Alterations of Fas (Apo-1/CD95) Gene in Cutaneous Malignant Melanoma

1999 • 136 citations

A Novel AP-1 Element in the CD95 Ligand Promoter Is Required for Induction of Apoptosis in Hepatocellular Carcinoma Cells upon Treatment with Anticancer Drugs

2000 • 132 citations

Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death.

1999 • 131 citations

Mutation of CD95 (Fas/Apo-1) Gene in Adult T-Cell Leukemia Cells

1998 • 130 citations

Tumor expression of Fas ligand (CD95L) and the consequences

1998 • 126 citations

Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway.

1996 • 126 citations

Alterations of Fas (APO-1/CD95) gene in transitional cell carcinomas of urinary bladder.

1999 • 121 citations

9-cis Retinoic Acid Inhibition of Activation-Induced Apoptosis Is Mediated via Regulation of Fas Ligand and Requires Retinoic Acid Receptor and Retinoid X Receptor Activation

1995 • 105 citations

Protein Kinase Cθ Cooperates with Calcineurin to Induce Fas Ligand Expression During Activation-Induced T Cell Death

1999 • 105 citations

HIV‐1 upregulates Fas ligand expression in CD4⁺ T cells in vitro and in vivo : association with Fas‐mediated apoptosis and modulation by aurintricarboxylic acid

1996 • 105 citations

Decreased antioxidant defence in individuals infected by the human immunodeficiency virus

2000 • 105 citations

Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells.

2000 • 104 citations

Protein kinase C-θ: signaling from the center of the T-cell synapse

2002 • 104 citations

The molecular basis of glucocorticoid-induced apoptosis of lymphoblastic leukemia cells

2000 • 104 citations

Somatic Mutations of Fas (Apo-1/CD95) Gene in Cutaneous Squamous Cell Carcinoma Arising from a Burn Scar

2000 • 98 citations

The IFN Regulatory Factor Family Participates in Regulation of Fas Ligand Gene Expression in T Cells

2000 • 94 citations

[22] Vitamin E status and immune function

1997 • 93 citations

T cell activation-induced and HIV Tat-enhanced CD95(APO-1 / Fas) ligand transcription involves NF-κB

2000 • 88 citations

Coactivators in transcription initiation: here are your orders

2002 • 87 citations

Role of Egr-2 in Up-regulation of Fas Ligand in Normal T Cells and Aberrant Double-negative lpr and gld T Cells

1999 • 86 citations

Proteasome regulation of activation-induced T cell death

1997 • 84 citations

Expression of Fas Ligand in Activated T Cells Is Regulated by c-Myc

2000 • 84 citations

Sp1 Phosphorylation Regulates Apoptosis via Extracellular FasL-Fas Engagement

2001 • 83 citations

Expression and function of Fas antigen on activated murine B cells

1996 • 81 citations

Interferon-γ Induces Apoptosis and Augments the Expression of Fas and Fas Ligand by Microglia in Vitro

2000 • 79 citations

Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Inhibit Expression of Fas Ligand in Activated T Lymphocytes by Regulating c-Myc, NF-κB, NF-AT, and Early Growth Factors 2/3

2001 • 78 citations

Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: a potential role for transcription factor NF-κB

1997 • 78 citations

Cutting Edge: The Tumor Counterattack Hypothesis Revisited: Colon Cancer Cells Do Not Induce T Cell Apoptosis Via the Fas (CD95, APO-1) Pathway

2000 • 77 citations

Constitutive Fas Ligand Gene Transcription in Sertoli Cells Is Regulated By Sp1

1999 • 76 citations

Expression of Fas in B cells of the mouse germinal center and Fas-dependent killing of activated B cells

1995 • 73 citations

Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation

1999 • 73 citations

Viral IFN-Regulatory Factors Inhibit Activation-Induced Cell Death Via Two Positive Regulatory IFN-Regulatory Factor 1-Dependent Domains in the CD95 Ligand Promoter

2002 • 72 citations

Membrane and Soluble Forms of Fas (CD95) and Fas Ligand in Peripheral Blood Mononuclear Cells and in Plasma from Human Immunodeficiency Virus‐Infected Persons

1998 • 72 citations

NF-κB-dependent Fas ligand expression

1999 • 71 citations

Lck is necessary and sufficient for Fas-ligand expression and apoptotic cell death in mature cycling T cells.

1997 • 68 citations

Fungal metabolite FR901228 inhibits c-Myc and Fas ligand expression

1998 • 67 citations

Somatic mutations in the death domain of theFas (Apo-1/CD95) gene in gastric cancer

2001 • 66 citations

Cutting Edge: The Class II Transactivator Prevents Activation-Induced Cell Death by Inhibiting Fas Ligand Gene Expression

2001 • 64 citations

Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death

2002 • 63 citations

DNA Damage Signals Induction of Fas Ligand in Tumor Cells

1999 • 62 citations

Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis

1997 • 62 citations

Nur77 transcription activity correlates with its apoptotic functionin vivo

1999 • 61 citations

Retinoic acid inhibition of ex vivo human immunodeficiency virus-associated apoptosis of peripheral blood cells.

1995 • 60 citations

A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation

1998 • 59 citations

Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide

1997 • 59 citations

Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death

2002 • 58 citations

ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis.

1997 • 58 citations

FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3

1999 • 57 citations

Lymphoproliferative disorders of natural killer cells.

1996 • 57 citations

Fas receptor counterattack against tumor-infiltrating lymphocytes in vivo as a mechanism of immune escape in gastric carcinoma

2001 • 56 citations

An unexpected role for FosB in activation-induced cell death of T cells

2003 • 54 citations

Synergistic action of protein kinase C θ and calcineurin is sufficient for Fas ligand expression and induction of a crmA-sensitive apoptosis pathway in Jurkat T cells

1999 • 52 citations

Differential Expression of Fas Ligand in Th1 and Th2 Cells Is Regulated by Early Growth Response Gene and NF-AT Family Members

2001 • 52 citations

Glucocorticoids rescue CD4+ T lymphocytes from activation-induced apoptosis triggered by HIV-1

1995 • 51 citations

A ‘non-canonical’ DNA-binding element mediates the response of the Fas-ligand promoter to c-Myc

2000 • 51 citations

Distinct Regulation of T-Cell Death by CD28 Depending on Both Its Aggregation and T-Cell Receptor Triggering: A Role for Fas-FasL

1998 • 50 citations

Frequent mutations of Fas gene in thyroid lymphoma.

2001 • 44 citations

Proteasome regulation of Fas ligand cytotoxicity

1997 • 44 citations

Loss of Fas (CD95/APO-1) Regulatory Function Is an Important Step in Early MALT-Type Lymphoma Development

2001 • 41 citations

HIV Tat Binds Egr Proteins and Enhances Egr-dependent Transactivation of the Fas Ligand Promoter

2002 • 41 citations

Regulation of CD95 (APO-1/ FAS) ligand and receptor expression in squamous-cell carcinoma by interferon-? and cisplatin

1999 • 39 citations

The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells

2002 • 38 citations

Fas Gene Mutations in Prostatic Intraepithelial Neoplasia and Concurrent Carcinoma: Analysis of Laser Capture Microdissected Specimens

2001 • 36 citations

Aberrant Expression of Fas Ligand in Mice Deficient for the MHC Class II Transactivator

2002 • 35 citations

T cell signaling:

1999 • 33 citations

Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4

1999 • 27 citations

Repression of FasL expression by retinoic acid involves a novel mechanism of inhibition of transactivation function of the nuclear factors of activated T‐cells

2002 • 24 citations

Differential inducibility of the transcriptional repressor ICER and its role in modulation of Fas ligand expression in T and NK lymphocytes

2002 • 23 citations

The essential role of phorbol ester-sensitive protein kinase C isoforms in activation-induced cell death of Th1 cells

1999 • 23 citations

Thymic Expression of the Transcription Factor Nur77 Rescues the T Cell But Not the B Cell Abnormality of gld/gld Mice

1998 • 22 citations

Selective Upregulation of Fibroblast Fas Ligand Expression, and Prolongation of Fas/Fas Ligand-Mediated Skin Allograft Survival, by Retinoic Acid: the Skin as a Retinoide-Inducible Immune Privilege Site

2000 • 22 citations

All‐TransRetinoic Acid Inhibition of Anti‐CD3–Induced T Cell Apoptosis in Human Immunodeficiency Virus Infection Mostly Concerns CD4 T Lymphocytes and Is Mediated via Regulation of CD95 Ligand Expression

1998 • 20 citations

Regulation of CD95 (Apo-1/Fas) Ligand and Receptor Expression in Human Embryonal Carcinoma Cells by Interferon γ and all-trans Retinoic Acid

1998 • 19 citations

All-trans retinoic acid modulates Fas antigen expression and affects cell proliferation and apoptosis in combination with anti-Fas monoclonal antibody in the human myeloma cell line, U266B1.

1998 • 19 citations

The Regulation of CD95 (Fas) Ligand Expression in Primary T Cells: Induction of Promoter Activation in CD95LP-Luc Transgenic Mice

2000 • 19 citations

Correlation of Loss of CD4 T Cells with Plasma Levels of Both Soluble Form Fas (CD95) and Fas Ligand (FasL) in HIV-Infected Infants

2000 • 14 citations

Sp1 is the majorfaslgene activator in abnormal CD4-CD8-B220+ T cells oflprandgldmice

2001 • 10 citations

Alteration of Fas/FasL expression of oral squamous cell carcinoma cell line Tca83 induced by retinoic acid.

2000 • 4 citations

[Retinoic acid inducing Fas expression in HL-60 cells].

1998 • 2 citations