Distinct Regulation of T-Cell Death by CD28 Depending on Both Its Aggregation and T-Cell Receptor Triggering: A Role for Fas-FasL

Apoptosis by Death Factor

1997 • 5,038 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

The Fas Death Factor

1995 • 4,070 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Negative selection of lymphocytes

1994 • 810 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

A Selective Procedure for DNA Extraction from Apoptotic Cells Applicable for Gel Electrophoresis and Flow Cytometry

1994 • 670 citations

A License to Kill

1996 • 649 citations

Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice

1996 • 456 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes.

1996 • 443 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

1997 • 437 citations

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

1995 • 431 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more

1995 • 394 citations

An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1

1996 • 375 citations

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.

1993 • 341 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 334 citations

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice

1996 • 325 citations

Costimulation of T cells for tumor immunity

1993 • 324 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 294 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids.

1995 • 230 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

Self-reactive γδ T cells are eliminated in the thymus

1990 • 221 citations

Differential Regulation of HIV-1 Fusion Cofactor Expression by CD28 Costimulation of CD4⁺T Cells

1997 • 206 citations

T cell receptor‐induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A

1994 • 206 citations

Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation.

1990 • 201 citations

Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells.

1993 • 198 citations

Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation.

1989 • 194 citations

Apoptosis and the maintenance of homoeostasis in the immune system

1996 • 178 citations

The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras.

1994 • 169 citations

Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events.

1997 • 167 citations

Fas Modulation of Apoptosis during Negative Selection of Thymocytes

1996 • 162 citations

Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death.

1993 • 152 citations

CD28 and apoptosis

1995 • 147 citations

T Cell Receptor (TCR)-induced Death of Immature CD4+CD8+ Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus

1997 • 118 citations

Differential regulation of bcl-2 and bcl-x by CD3, CD28, and the IL-2 receptor in cloned CD4+ helper T cells. A model for the long-term survival of memory cells.

1996 • 110 citations

T cell receptor-mediated DNA fragmentation and cell death in T cell hybridomas.

1990 • 98 citations

Essential genes that regulate apoptosis

1994 • 87 citations

Activation of CD4⁺ T cells by delivery of the B7 costimulatory signal on bystander antigen‐presenting cells (trans‐costimulation)

1994 • 86 citations

Life and death during lymphocyte development and function: evidence for two distinct killing mechanisms

1995 • 85 citations

Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes.

1996 • 84 citations

TNF receptor-2-triggered apoptosis is associated with the down-regulation of Bcl-xL on activated T cells and can be prevented by CD28 costimulation.

1997 • 79 citations

Specific Th1 cytokine down-regulation associated with primary clinically derived human immunodeficiency virus type 1 Nef gene-induced expression.

1996 • 76 citations

T Cell Receptor Signals Enhance Susceptibility to Fas-mediated Apoptosis

1997 • 72 citations

Expansion and clonal deletion of peripheral T cells induced by bacterial superantigen is independent of the interleukin‐2 pathway

1992 • 70 citations

Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death.

1997 • 69 citations

Lck is necessary and sufficient for Fas-ligand expression and apoptotic cell death in mature cycling T cells.

1997 • 68 citations

Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3-Kinase Association

1996 • 63 citations

Maintenance of clonotype specificity in CD95/Apo-1/Fas-mediated apoptosis of mature T lymphocytes.

1997 • 62 citations

Herpes simplex virus type 2 inhibition of Fas ligand expression

1996 • 61 citations

Signalling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity

1993 • 44 citations

CD28 can promote T cell survival through a phosphatidylinositol 3‐kinase‐independent mechanism

1997 • 43 citations

Analyses of the Cytoskeleton in Saccharomyces cerevisiae

1991 • 41 citations

The CD28 and CTLA-4 Receptor Family1

2015 • 26 citations

T cell antigen receptor-induced IL-2 production and apoptosis have different requirements for Lck activities.

1997 • 20 citations

The CD28 and CTLA-4 Receptor Family (Part 1 of 2)

1994 • 16 citations