Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

The Fas Death Factor

1995 • 4,070 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Genetic disease detection and DNA amplification using cloned thermostable ligase.

1991 • 803 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene

1988 • 661 citations

Expression of the Fas ligand in cells of T cell lineage.

1995 • 659 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

1991 • 566 citations

Positive selection of lymphocytes

1994 • 563 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

1995 • 548 citations

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

1988 • 532 citations

Human Fas ligand: gene structure, chromosomal location and species specificity

1994 • 435 citations

The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.

1993 • 397 citations

Identification of a new brain-specific transcription factor, NURR1.

1992 • 373 citations

The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

1994 • 335 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)

1995 • 273 citations

In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes.

1991 • 199 citations

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

1995 • 197 citations

TCR/CD3 coupling to Fas-based cytotoxicity.

1995 • 196 citations

Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation.

1989 • 194 citations

Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor.

1989 • 188 citations

Molecular Cloning of a Novel Thyroid/Steroid Receptor Superfamily Gene from Cultured Rat Neuronal Cells

1994 • 187 citations

Adrenocortical Function and Regulation of the Steroid 21-Hydroxylase Gene in NGFI-B-Deficient Mice

1995 • 146 citations

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

1992 • 130 citations

Tolerance-related V beta clonal deletions in normal CD4-8-, TCR-alpha/beta + and abnormal lpr and gld cell populations.

1989 • 127 citations

Functional dissection of the lck proximal promoter.

1992 • 120 citations

Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen.

1994 • 120 citations

Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77.

1995 • 99 citations

Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice.

1991 • 97 citations

Interleukin 4 expressed in situ selectively alters thymocyte development.

1991 • 86 citations

The Orphan Receptors NGFI-B and Steroidogenic Factor 1 Establish Monomer Binding as a Third Paradigm of Nuclear Receptor-DNA Interaction

1993 • 62 citations

Functional Dissection of the lck Proximal Promoter

1992 • 51 citations

Overexpression of RelA in Transgenic Mouse Thymocytes: Specific Increase in Levels of the Inhibitor Protein IκBα

1995 • 49 citations

The onset of Fas expression parallels the acquisition of CD8 and CD4 in fetal and adult αβ thymocytes

1994 • 45 citations

Deletion analysis of the human CD2 gene locus control region in transgenic mice

1991 • 41 citations

Overexpression of RelB in transgenic mice does not affect I kappa B alpha levels: differential regulation of RelA and RelB by the inhibitor protein.

1996 • 21 citations