Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death.

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 • 1,589 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Rottlerin, a Novel Protein Kinase Inhibitor

1994 • 839 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival

1998 • 742 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1995 • 684 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

1996 • 535 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1993 • 344 citations

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

1996 • 344 citations

Caspase-3-mediated Cleavage of Protein Kinase C θ in Induction of Apoptosis

1997 • 308 citations

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.

1993 • 306 citations

Functional and Physical Interactions of Syk Family Kinases with the Vav Proto-Oncogene Product

1996 • 281 citations

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1998 • 270 citations

Regulation of Fas-Ligand Expression during Activation-induced Cell Death in T Lymphocytes via Nuclear Factor κB

1999 • 257 citations

Protein Kinase C-θ Isoenzyme Selective Stimulation of the Transcription Factor Complex AP-1 in T Lymphocytes

1996 • 251 citations

Activation-induced death of mature T cells in the regulation of immune responses

1995 • 248 citations

Two NFAT Transcription Factor Binding Sites Participate in the Regulation of CD95 (Fas) Ligand Expression in Activated Human T Cells

1997 • 222 citations

T cell receptor‐induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A

1994 • 206 citations

Stress-Induced Fas Ligand Expression in T Cells Is Mediated through a MEK Kinase 1-Regulated Response Element in the Fas Ligand Promoter

1998 • 193 citations

Activation of the CPP32 protease in apoptosis induced by 1-beta-D- arabinofuranosylcytosine and other DNA-damaging agents

1996 • 171 citations

Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events.

1997 • 167 citations

Transcriptional Regulation of the Human FasL Promoter-Enhancer Region

1998 • 156 citations

Coordinate Regulation of Stress- and Mitogen-Activated Protein Kinases in the Apoptotic Actions of Ceramide and Sphingosine

1997 • 153 citations

Fas-ligand: Privilege and peril

1997 • 142 citations

Phosphorylation of Bcl-2 Protein and Association with p21Ras in Ras-induced Apoptosis

1996 • 132 citations

Cooperation between Syk and Rac1 Leads to Synergistic JNK Activation in T Lymphocytes

1998 • 125 citations

Activation-induced cell death in murine T cell hybridomas. Differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506

1996 • 122 citations

Activation of protein kinase Cdelta in human myeloid leukemia cells treated with 1-beta-D-arabinofuranosylcytosine

1996 • 119 citations

lnterleukin-2 transcriptional block by multifunctional Ca2+/ calmodulin kinase

1994 • 115 citations

Protein kinase Cθ, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells

1999 • 113 citations

Effects of transiently expressed atypical (ζ, λ), conventional (α, β) and novel (δ, ɛ) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific interchangeable effects of protein kinases C-ζ and C-λ

1999 • 110 citations

Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: a potential role for transcription factor NF-κB

1997 • 78 citations

Induction of Thymocyte Apoptosis by Ca2+-independent Protein Kinase C (nPKC) Activation and Its Regulation by Calcineurin Activation

1998 • 66 citations

Ras-dependent, Ca2+-stimulated Activation of Nuclear Factor of Activated T Cells by a Constitutively Active Cbl Mutant in T Cells

1997 • 63 citations

ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis.

1997 • 58 citations

Cross-Talk between Protein Kinase C-α (PKC-α) and -δ (PKC-δ): PKC-α Elevates the PKC-δ Protein Level, Altering Its mRNA Transcription and Degradation

1998 • 53 citations

Synergistic action of protein kinase C θ and calcineurin is sufficient for Fas ligand expression and induction of a crmA-sensitive apoptosis pathway in Jurkat T cells

1999 • 52 citations

Apoptosis but Not Other Activation Events Is Inhibited by a Mutation in the Transmembrane Domain of T Cell Receptor β That Impairs CD3ζ Association

1996 • 46 citations

Ras activation leads to cell proliferation or apoptotic cell death upon interleukin‐2 stimulation or lymphokine deprivation, respectively

1997 • 46 citations

T Cell Receptor (TCR) Engagement in Apoptosis-defective, but Interleukin 2 (IL-2)–producing, T Cells Results in Impaired ZAP70/CD3-ζ Association

1998 • 42 citations

Protein Kinase C Activation Inhibits Tyrosine Phosphorylation of Cbl and Its Recruitment of Src Homology 2 Domain-Containing Proteins

1999 • 41 citations

A newly identified response element in the CD95 ligand promoter contributes to optimal inducibility in activated T lymphocytes.

1998 • 34 citations

A possible role for PKCδ in cerebellar granule cells apoptosis

1998 • 34 citations

Bisindolylmaleimide prevents cerebellar granule cells apoptosis

1998 • 16 citations