Nuclear Hormone Receptors in T Lymphocytes

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

DNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival

1998 • 1,081 citations

Dopamine Neuron Agenesis in Nurr1-Deficient Mice

1997 • 1,075 citations

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

1995 • 926 citations

Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

1999 • 841 citations

Glucocorticoids in T Cell Development and Function

2000 • 783 citations

Requirement for RORγ in Thymocyte Survival and Lymphoid Organ Development

2000 • 714 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Developing Lymph Nodes Collect CD4 + CD3 − LTβ + Cells That Can Differentiate to APC, NK Cells, and Follicular Cells but Not T or B Cells

1997 • 654 citations

Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3

2000 • 651 citations

Components of a New Human Protein Kinase Signal Transduction Pathway

1995 • 644 citations

DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES

1999 • 636 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Positive Selection of Thymocytes

1995 • 604 citations

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

2001 • 575 citations

Gene regulation mediated by calcium signals in T lymphocytes

2001 • 572 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

1995 • 548 citations

HDAC4 deacetylase associates with and represses the MEF2 transcription factor

1999 • 539 citations

Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

2001 • 434 citations

Bcl-XL and Bcl-2 repress a common pathway of cell death.

1995 • 406 citations

Transcriptional Repression of the Interleukin-2 Gene by Vitamin D₃: Direct Inhibition of NFATp/AP-1 Complex Formation by a Nuclear Hormone Receptor

1995 • 399 citations

Novel Dimeric Nur77 Signaling Mechanism in Endocrine and Lymphoid Cells

1997 • 366 citations

THE ROLE OF THEhsp90-BASED CHAPERONE SYSTEM IN SIGNAL TRANSDUCTION BY NUCLEAR RECEPTORS AND RECEPTORS SIGNALING VIA MAP KINASE

1997 • 329 citations

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

1997 • 315 citations

Nuclear-Receptor Ligands and Ligand-Binding Domains

1999 • 314 citations

Retinoid-related orphan receptor γ (RORγ) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis

2000 • 308 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)

1995 • 273 citations

ERK5 Is a Novel Type of Mitogen-Activated Protein Kinase Containing a Transcriptional Activation Domain

2000 • 263 citations

Regulation of Peripheral Lymph Node Genesis by the Tumor Necrosis Factor Family Member Trance

2000 • 262 citations

Apoptosis of T Cells Mediated by Ca ²⁺ -Induced Release of the Transcription Factor MEF2

1999 • 262 citations

RORγt, a Novel Isoform of an Orphan Receptor, Negatively Regulates Fas Ligand Expression and IL-2 Production in T Cells

1998 • 235 citations

Cross-talk between glucocorticoid receptor and AP-1

2001 • 231 citations

Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids.

1995 • 230 citations

Glucocorticoids down‐regulate dendritic cell function in vitro and in vivo

1995 • 220 citations

Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis

2000 • 216 citations

Regulation of the Nur77 Orphan Steroid Receptor in Activation-Induced Apoptosis

1995 • 216 citations

ROR-γ: The Third Member of ROR/RZR Orphan Receptor Subfamily That Is Highly Expressed in Skeletal Muscle

1994 • 211 citations

Mice with an Increased Glucocorticoid Receptor Gene Dosage Show Enhanced Resistance to Stress and Endotoxic Shock

2000 • 202 citations

Ca2+-dependent Gene Expression Mediated by MEF2 Transcription Factors

2000 • 196 citations

MEF-2 function is modified by a novel co-repressor, MITR

1999 • 194 citations

A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis

1998 • 192 citations

MEKK3 Directly Regulates MEK5 Activity as Part of the Big Mitogen-activated Protein Kinase 1 (BMK1) Signaling Pathway

1999 • 187 citations

Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B

2000 • 186 citations

Glucocorticoids Inhibit Bioactive IL-12p70 Production by In Vitro-Generated Human Dendritic Cells Without Affecting Their T Cell Stimulatory Potential

1998 • 181 citations

Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations.

1999 • 180 citations

Nuclear factor of activated T cells (NFAT) as a molecular target for 1alpha,25-dihydroxyvitamin D3-mediated effects.

1998 • 180 citations

Molecular Determinants of AHPN (CD437)-Induced Growth Arrest and Apoptosis in Human Lung Cancer Cell Lines

1998 • 176 citations

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

2001 • 168 citations

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.

1996 • 161 citations

Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization

1997 • 160 citations

Cabin1 Represses MEF2-Dependent Nur77 Expression and T Cell Apoptosis by Controlling Association of Histone Deacetylases and Acetylases with MEF2

2000 • 156 citations

Akt Inhibits the Orphan Nuclear Receptor Nur77 and T-cell Apoptosis

2001 • 150 citations

Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses.

1993 • 138 citations

Several Different Cell Surface Molecules Control Negative Selection of Medullary Thymocytes

1999 • 127 citations

Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway.

1996 • 126 citations

Intrathymic T Cell Development and Selection Proceeds Normally in the Absence of Glucocorticoid Receptor Signaling

2000 • 117 citations

Requirement for the NF-κB Family Member RelA in the Development of Secondary Lymphoid Organs

2002 • 105 citations

9-cis Retinoic Acid Inhibition of Activation-Induced Apoptosis Is Mediated via Regulation of Fas Ligand and Requires Retinoic Acid Receptor and Retinoid X Receptor Activation

1995 • 105 citations

Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling

2000 • 105 citations

A Two-Hit Mechanism for Vitamin D₃-Mediated Transcriptional Repression of the Granulocyte-Macrophage Colony-Stimulating Factor Gene: Vitamin D Receptor Competes for DNA Binding with NFAT1 and Stabilizes c-Jun

1999 • 95 citations

Transcriptional activation of the inducible nuclear receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells.

1993 • 78 citations

RORγT, a thymus-specific isoform of the orphan nuclear receptor RORγ / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter

1999 • 77 citations

The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo

2001 • 73 citations

Role reversal: new insights from new ligands for the xenobiotic receptor CAR

2001 • 72 citations

Induction of early response genes by cross-linking membrane Ig on B lymphocytes.

1993 • 72 citations

TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals.

1995 • 67 citations

Peroxisome proliferator-activated receptors in macrophage biology: friend or foe?

2001 • 64 citations

Deletion of Calcineurin and Myocyte Enhancer Factor 2 (MEF2) Binding Domain of Cabin1 Results in Enhanced Cytokine Gene Expression in T Cells

2001 • 63 citations

Nur77 transcription activity correlates with its apoptotic functionin vivo

1999 • 61 citations

Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity.

2001 • 60 citations

The TNF Receptor Family Member CD30 Is Not Essential for Negative Selection

2000 • 50 citations

Retinoic Acid and Its Receptors Repress the Expression and Transactivation Functions of Nur77: A Possible Mechanism for the Inhibition of Apoptosis by Retinoic Acid

2000 • 47 citations

Role of the Nuclear Hormone Receptor ROR in Transcriptional Regulation, Thymocyte Survival, and Lymphoid Organogenesis

1999 • 39 citations

Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4⁺CD8⁺thymocytes

1999 • 35 citations

Activation-induced apoptosis and cell surface expression of Fas (CD95) ligand are reciprocally regulated by retinoic acid receptor α and γ and involve nur77 in T cells

2001 • 30 citations

Thymic Expression of the Transcription Factor Nur77 Rescues the T Cell But Not the B Cell Abnormality of gld/gld Mice

1998 • 22 citations

Receptor-mediated Apoptosis in T Lymphocytes

1999 • 19 citations