Cysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones

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Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

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The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

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The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

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NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

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NF-κB as a Frequent Target for Immunosuppressive and Anti-Inflammatory Molecules**This article was accepted for publication on 27 September 1996.

1997 • 472 citations

The Anti-inflammatory Sesquiterpene Lactone Helenalin Inhibits the Transcription Factor NF-κB by Directly Targeting p65

1998 • 462 citations

Isolation of a rel -related Human cDNAThat Potentially Encodes the 65-kD Subunit of NF-κB

1991 • 448 citations

The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.

1999 • 381 citations

Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase

2000 • 353 citations

The Antiinflammatory Sesquiterpene Lactone Parthenolide Inhibits NF-κB by Targeting the IκB Kinase Complex

1999 • 336 citations

Sesquiterpene Lactones Specifically Inhibit Activation of NF-κB by Preventing the Degradation of IκB-α and IκB-β

1998 • 325 citations

Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation

1999 • 285 citations

Helenalin, an Anti-Inflammatory Sesquiterpene Lactone from Arnica, Selectively Inhibits Transcription Factor NF-κB

1997 • 248 citations

Inhibition of transcription factor NF-κB by sesquiterpene lactones: a proposed molecular mechanism of action

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A novel DNA recognition mode by the NF-κB p65 homodimer

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Anti-Inflammatory Activity of Sesquiterpene Lactones and Related Compounds

1979 • 177 citations

The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.

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Feverfew: chemistry and biological activity

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Helenanolide-type sesquiterpene lactones—III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules

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Mode of action of sesquiterpene lactones as anti-inflammatory agents

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Anti-inflammatory Effects of South American Tanacetum vulgare

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A Sesquiterpene, Dehydrocostus Lactone, Inhibits the Expression of Inducible Nitric Oxide Synthase and TNF-α in LPS-Activated Macrophages

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IκB Kinases α and β Show a Random Sequential Kinetic Mechanism and Are Inhibited by Staurosporine and Quercetin

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Hagers Handbuch der pharmazeutischen Praxis

1991 • 93 citations

Inhibitory Effect of Sesquiterpene Lactones fromSaussurea lappaon Tumor Necrosis Factor-α Production in Murine Macrophage-Like Cells

1998 • 87 citations

Sesquiterpene Lactones Inhibit Inducible Nitric Oxide Synthase Gene Expression in Cultured Rat Aortic Smooth Muscle Cells

1999 • 77 citations

Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione

1979 • 76 citations

Study of Three Sesquiterpene Lactones fromTithonia diversifoliaon their Anti-Inflammatory Activity Using the Transcription Factor NF-κB and Enzymes of the Arachidonic Acid Pathway as Targets

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Suppression of TNF?-mediated NF?b activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells

1999 • 72 citations

SESQUITERPENE LACTONES ARE POTENT INHIBITORS OF INTERLEUKIN 8 GENE EXPRESSION IN CULTURED HUMAN RESPIRATORY EPITHELIUM

2000 • 63 citations

Helenalin and 11α,13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways

1990 • 61 citations

Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of NF-κB 1 1Abbreviations: Con A, concanavalin A; HBSS, Hanks’ balanced salt solution; IL, interleukin; iNOS, inducible nitric oxide synthase; LPS, lipopolysaccharide; NF-κB, nuclear factor kappaB; NO, nitric oxide; PEC, mouse peritoneal exsudate cell; TNF-α, tumor necrosis factor α; and Sl(s), sesquiterpene lactone(s).

2001 • 59 citations

Reaction of Alantolactone, an Allergenic Sesquiterpene Lactone, with some Amino Acids. Resultant Loss of Immunologic Reactivity

1974 • 52 citations

Study of sesquiterpene lactones from Milleria quinqueflora on their anti-inflammatory activity using the transcription factor NF-κB as molecular target

2000 • 43 citations

Transcription-Independent Turnover of IκBα during Monocyte Adherence: Implications for a Translational Component Regulating IκBα/MAD-3 mRNA Levels

1995 • 43 citations

Inhibition of the Transcription Factor NF-κB by Sesquiterpene Lactones fromPodachaenium eminens1

2000 • 41 citations

Characterization of NFκB Activation by Detection of Green Fluorescent Protein-tagged IκB Degradation in Living Cells

1999 • 33 citations

Flavonoide ausArnica montanaundArnica chamissonis¹

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Anti-Inflammatory Activities of Hypocretenolides from Leontodon hispidus

1999 • 22 citations

Coordinate Induction of IKBαand NFKB Genes

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Weitere Helenanolide aus den Blüten vonArnica chamissonissubsp.foliosa^1,2,3

1990 • 17 citations

Herbal Medicinal Products for the Treatment of Pain

2000 • 10 citations