Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases

A catalogue of splice junction sequences

1982 • 3,861 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Mechanisms of Alternative Pre-Messenger RNA Splicing

2003 • 2,547 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

2000 • 1,878 citations

Messenger-RNA-binding proteins and the messages they carry

2002 • 1,398 citations

Pre-mRNA splicing and human disease

2003 • 1,242 citations

Alternative splicing: increasing diversity in the proteomic world

2001 • 1,218 citations

Exon Recognition in Vertebrate Splicing

1995 • 1,067 citations

Sorting out the complexity of SR protein functions

2000 • 1,064 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Alternative pre-mRNA splicing: the logic of combinatorial control

2000 • 892 citations

Altered microtubule organization in small-calibre axons of mice lacking tau protein

1994 • 742 citations

Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases

2000 • 689 citations

The Primary Structure and Heterogeneity of Tau Protein from Mouse Brain

1988 • 671 citations

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain.

1995 • 601 citations

Developmentally regulated expression of specific tau sequences

1989 • 589 citations

Structure and novel exons of the human .tau. gene

1992 • 587 citations

Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

1992 • 569 citations

Split genes and RNA splicing

1994 • 562 citations

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

1986 • 535 citations

Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

1999 • 506 citations

Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins

1998 • 505 citations

Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice

2001 • 495 citations

Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex

1998 • 486 citations

Tau Consists of a Set of Proteins with Repeated C-Terminal Microtubule-Binding Domains and Variable N-Terminal Domains

1989 • 478 citations

The microtubule binding domain of tau protein

1989 • 472 citations

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

1998 • 464 citations

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

1997 • 438 citations

Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR

1990 • 426 citations

The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing

2001 • 420 citations

Phosphorylation of Tau by Fyn: Implications for Alzheimer's Disease

2004 • 396 citations

Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes.

1995 • 366 citations

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains.

1989 • 321 citations

Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family.

1989 • 306 citations

Yeast actin-binding proteins: evidence for a role in morphogenesis.

1988 • 304 citations

Tau domains, phosphorylation, and interactions with microtubules

1995 • 299 citations

5′ Splice Site Mutations in tau Associated with the Inherited Dementia FTDP-17 Affect a Stem-Loop Structure That Regulates Alternative Splicing of Exon 10

1999 • 294 citations

Initial splice-site recognition and pairing during pre-mRNA splicing

1996 • 281 citations

Discussion

1997 • 279 citations

Dysregulation of human brain microtubule-associated tau mRNA maturation in myotonic dystrophy type 1

2001 • 272 citations

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly.

1997 • 270 citations

Scanning from an independently specified branch point defines the 3′ splice site of mammalian introns

1989 • 267 citations

Tau Is Enriched on Dynamic Microtubules in the Distal Region of Growing Axons

1996 • 259 citations

Mechanisms of Alternative Pre-mRNA Splicing

1991 • 257 citations

Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system.

1992 • 249 citations

Tau Binds to the Distal Axon Early in Development of Polarity in a Microtubule- and Microfilament-Dependent Manner

1996 • 238 citations

Identification of a New Class of Exonic Splicing Enhancers by In Vivo Selection

1997 • 237 citations

Tau Cleavage and Dephosphorylation in Cerebellar Granule Neurons Undergoing Apoptosis

1998 • 233 citations

Primary structure of high molecular weight tau present in the peripheral nervous system.

1992 • 232 citations

hnRNP A1 Recruited to an Exon In Vivo Can Function as an Exon Splicing Silencer

1999 • 219 citations

Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice

2000 • 210 citations

Co-transcriptional commitment to alternative splice site selection

1998 • 195 citations

The Neuronal Microtubule‐Associated Protein Tau Is a Substrate for Caspase‐3 and an Effector of Apoptosis

2000 • 191 citations

Tau gene mutations: dissecting the pathogenesis of FTDP-17

2002 • 174 citations

Functions and malfunctions of the tau proteins

2002 • 167 citations

Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells.

1988 • 160 citations

Tau and transgenic animal models

2001 • 160 citations

Transgenic Mouse Model of Tauopathies with Glial Pathology and Nervous System Degeneration

2002 • 144 citations

Sorting mechanisms of Tau and MAP2 in neurons: Suppressed axonal transit of MAP2 and locally regulated microtubule binding

1995 • 138 citations

Aberrant Splicing of tau Pre-mRNA Caused by Intronic Mutations Associated with the Inherited Dementia Frontotemporal Dementia with Parkinsonism Linked to Chromosome 17

2000 • 131 citations

Determinants of 4-Repeat Tau Expression

2000 • 129 citations

Amount of RNA secondary structure required to induce an alternative splice.

1987 • 128 citations

Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia

2003 • 125 citations

An Intron Element Modulating 5′ Splice Site Selection in the hnRNP A1 Pre-mRNA Interacts with hnRNP A1

1997 • 123 citations

Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors

2004 • 120 citations

A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau.

1993 • 119 citations

Regulation of Alternative Splicing of Human Tau Exon 10 by Phosphorylation of Splicing Factors

2001 • 109 citations

Mutations in Tau Gene Exon 10 Associated with FTDP-17 Alter the Activity of an Exonic Splicing Enhancer to Interact with Tra2β

2003 • 107 citations

HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding

2003 • 105 citations

The STAR/GSG Family Protein rSLM-2 Regulates the Selection of Alternative Splice Sites

2001 • 97 citations

Inclusion-body myositis and myopathies: different etiologies, possibly similar pathogenic mechanisms

2002 • 97 citations

The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases

2004 • 95 citations

Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons

1999 • 90 citations

Tau gene expression in rat sensory neurons during development and regeneration

1991 • 89 citations

Complex Regulation of Tau Exon 10, Whose Missplicing Causes Frontotemporal Dementia

2000 • 88 citations

Identification of a Novel Neuronal C-SRC Exon Expressed in Human Brain

1990 • 88 citations

Expression of high molecular weight tau in the central and peripheral nervous systems

1993 • 87 citations

Alternative splicing in the nervous system: an emerging source of diversity and regulation

2003 • 86 citations

tau Exon 10 Expression Involves a Bipartite Intron 10 Regulatory Sequence and Weak 5′ and 3′ Splice Sites

2002 • 84 citations

Relative exon affinities and suboptimal splice site signals lead to non-equivalence of two cassette exons

1995 • 84 citations

cis‐Acting signals and trans‐acting proteins are involved in tau mRNA targeting into neurites of differentiating neuronal cells

1995 • 83 citations

Developmental changes of tau protein and mRNA in cultured rat brain oligodendrocytes

2001 • 81 citations

Defects in Pre-mRNA Processing as Causes of and Predisposition to Diseases

2002 • 80 citations

Microtubule-associated proteins (MAPs) in the peripheral nervous system during development and regeneration

1997 • 80 citations

The four Rs of RNA-directed evolution

2003 • 77 citations

Microfilament‐associated growth cone component depends upon Tau for its intracellular localization

1994 • 74 citations

Cell-Specific RNA-Binding Proteins in Human Disease

2003 • 71 citations

The exon sequence TAGG can inhibit splicing

1996 • 66 citations

Splicing of a Regulated Exon Reveals Additional Complexity in the Axonal Microtubule‐Associated Protein Tau

1998 • 64 citations

Identification of a novel neuronal C-SRC exon expressed in human brain.

1990 • 57 citations

Effects on splicing and protein function of three mutations in codon N296 of tau in vitro

2002 • 52 citations

Expression of specific tau exons in normal and tumoral pancreatic acinar cells

1998 • 51 citations

Novel Tau Polymorphisms, Tau Haplotypes, and Splicing in Familial and Sporadic Frontotemporal Dementia

2003 • 49 citations

Nucleolar localization of the microtubule-associated protein tau in neuroblastomas using sense and anti-sense transfection strategies

1997 • 47 citations

A τ Promoter Region Without Neuronal Specificity

1996 • 46 citations

Prediction and Statistical Analysis of Alternatively Spliced Exons

2003 • 46 citations

τ Regulation of Microtubule‐Microtubule Spacing and Bundling

1994 • 45 citations

Heterogeneity of tau proteins in Alzheimer's disease. Evidence for increased expression of an isoform and preferential distribution of a phosphorylated isoform in neurites.

1993 • 44 citations

Novel isoforms of tau that lack the microtubule‐binding domain

2004 • 42 citations

Novel Exonic Elements That Modulate Splicing of the Human Fibronectin EDA Exon

1997 • 42 citations

Complete Sequence of 3′-Untranslated Region of Tau from Rat Central Nervous System

1994 • 36 citations

Modulation of the membrane-binding domain of tau protein: splicing regulation of exon 2

2003 • 34 citations

Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3

2002 • 27 citations

Neuronal apoptosis is associated with a decrease in tau mRNA expression

1998 • 24 citations

The exon trapping assay partly discriminates against alternatively spliced exons

1993 • 23 citations

Tau isoforms which contain the domain encoded by exon 6 and their role in neurite elongation

2004 • 23 citations

The splicing determinants of a regulated exon in the axonal MAP tau reside within the exon and in its upstream intron

2000 • 21 citations

Chromosome 17-linked dementias

1998 • 20 citations

Expression of tau exon 8 in different species

1994 • 19 citations

Regulatory roles of microtubule-associated proteins in neuronal morphogenesis. Involvement of the extracellular matrix

1999 • 14 citations

Tau domains, phosphorylation, and interaction with microtubules

1995 • 8 citations

Increased levels of tau-like protein in patients with Down syndrome

1999 • 7 citations