An Intron Element Modulating 5′ Splice Site Selection in the hnRNP A1 Pre-mRNA Interacts with hnRNP A1

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Exon definition may facilitate splice site selection in RNAs with multiple exons.

1990 • 726 citations

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

1992 • 724 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

The superfamily of arginine/serine-rich splicing factors.

1995 • 671 citations

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

1994 • 612 citations

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

1985 • 568 citations

Split genes and RNA splicing

1994 • 562 citations

RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing.

1994 • 481 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1991 • 433 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

Positive autoregulation of Sex-lethal by alternative splicing maintains the female determined state in Drosophila

1991 • 336 citations

Control of doublesex Alternative Splicing by transformer and transformer-2 in Drosophila

1991 • 333 citations

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

1993 • 332 citations

Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.

1994 • 321 citations

The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA

1993 • 309 citations

A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding.

1993 • 300 citations

General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer.

1993 • 286 citations

SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex.

1994 • 267 citations

RNA binding specificity of hnRNP proteins: a subset bind to the 3′ end of introns.

1988 • 251 citations

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro

1991 • 244 citations

Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.

1993 • 241 citations

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon.

1992 • 225 citations

Polypurine sequences within a downstream exon function as a splicing enhancer.

1994 • 222 citations

RNA-RNA interactions in the spliceosome: Unraveling the ties that bind

1994 • 208 citations

Positive Control of Pre-mRNA Splicing in Vitro

1992 • 199 citations

The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event.

1995 • 194 citations

Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF.

1993 • 192 citations

The Cardiac troponin T Alternative Exon Contains a Novel Purine-Rich Positive Splicing Element

1993 • 189 citations

Finding splice sites within a wilderness of RNA.

1995 • 188 citations

Directing alternative splicing: cast and scenarios

1996 • 187 citations

The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo.

1994 • 186 citations

Regulation of doublesex pre-mRNA processing occurs by 3'-splice site activation.

1991 • 184 citations

A Subset of SR Proteins Activates Splicing of the Cardiac Troponin T Alternative Exon by Direct Interactions with an Exonic Enhancer

1995 • 180 citations

hnRNP A1 Selectively Interacts Through its Gly-rich Domain with Different RNA-binding Proteins

1996 • 179 citations

Regulation of alternative 3' splice site selection by constitutive splicing factors.

1995 • 170 citations

Synergistic interactions between two distinct elements of a regulated splicing enhancer.

1995 • 156 citations

Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element.

1994 • 150 citations

Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes.

1987 • 143 citations

A splicing enhancer exhibits both constitutive and regulated activities.

1994 • 136 citations

Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity.

1995 • 133 citations

Evidence that a regulatory gene autoregulates splicing of its transcript.

1987 • 123 citations

Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing.

1995 • 118 citations

An intronic (A/U)GGG repeat enhances the splicing of an alternative intron of the chicken β-tropomyosin pre-mRNA

1995 • 116 citations

Exon and Intron Sequences, Respectively, Repress and Activate Splicing of a Fibroblast Growth Factor Receptor 2 Alternative Exon

1995 • 113 citations

Autoregulation of the splicing of transcripts from the transformer-2 gene of Drosophila.

1991 • 102 citations

The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences.

1995 • 100 citations

An intron splicing enhancer containing a G-rich repeat facilitates inclusion of a vertebrate micro-exon.

1996 • 95 citations

Regulation of splicing at an intermediate step in the formation of the spliceosome.

1994 • 93 citations

Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein.

1990 • 86 citations

A native RNA secondary structure controls alternative splice-site selection and generates two human growth hormone isoforms.

1992 • 80 citations

Retroviral Insertions Downstream of the Heterogeneous Nuclear Ribonucleoprotein Al Gene in Erythroleukemia Cells: Evidence that Al Is Not Essential for Cell Growth

1992 • 79 citations

Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing.

1993 • 78 citations

The accumulation of mature RNA for the Xenopus laevis ribosomal protein L1 is controlled at the level of splicing and turnover of the precursor RNA.

1987 • 78 citations

Isolation of an active gene encoding human hnRNP protein A1

1989 • 77 citations

A highly stable duplex structure sequesters the 5' splice site region of hnRNP A1 alternative exon 7B.

1997 • 72 citations

Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements.

1993 • 68 citations

The exon sequence TAGG can inhibit splicing

1996 • 66 citations

Rapid assembly and disassembly of complementary DNA strands through an equilibrium intermediate state mediated by A1 hnRNP protein.

1992 • 57 citations

Mammalian Heterogeneous Ribonucleoprotein A1 and its Constituent Domains

1993 • 52 citations

Interaction of hnRNP A1 with snRNPs and pre-mRNAs: evidence for a possible role of A1 RNA annealing activity in the first steps of spliceosome assembly

1992 • 49 citations

Two Different Sequence Elements within Exon 4 Are Necessary for Calcitonin-Specific Splicing of the Human Calcitonin/Calcitonin Gene-Related Peptide I Pre-mRNA

1994 • 47 citations

Identification of cis-acting intron and exon regions in influenza virus NS1 mRNA that inhibit splicing and cause the formation of aberrantly sedimenting presplicing complexes.

1992 • 47 citations

Origins of Binding Specificity of the A1 Heterogeneous Nuclear Ribonucleoprotein

1996 • 44 citations

Alternative splicing of β-tropomyosin pre-mRNA: multiple cis-elements can contribute to the use of the 5′- and 3′-splice sites of the nonmuscle/smooth muscle exon 6

1994 • 37 citations

Identification of exon sequences involved in splice site selection.

1994 • 34 citations

β-Tropomyosin Pre-mRNA Folding Around a Muscle-specific Exon Interferes with Several Steps of Spliceosome Assembly

1995 • 32 citations

Human hnRNP protein A1: A model polypeptide for a structural and genetic investigation of a broad family of RNA binding proteins

1994 • 12 citations