Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Mechanisms of Alternative Pre-Messenger RNA Splicing

2003 • 2,547 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Listening to silence and understanding nonsense: exonic mutations that affect splicing

2002 • 2,143 citations

Messenger-RNA-binding proteins and the messages they carry

2002 • 1,398 citations

Pre-mRNA splicing and human disease

2003 • 1,242 citations

Alternative splicing: increasing diversity in the proteomic world

2001 • 1,218 citations

Sorting out the complexity of SR protein functions

2000 • 1,064 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Alternative pre-mRNA splicing: the logic of combinatorial control

2000 • 892 citations

Altered microtubule organization in small-calibre axons of mice lacking tau protein

1994 • 742 citations

Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases

2000 • 689 citations

Tau protein pathology in neurodegenerative diseases

1998 • 674 citations

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain.

1995 • 601 citations

Developmentally regulated expression of specific tau sequences

1989 • 589 citations

Structure and novel exons of the human .tau. gene

1992 • 587 citations

Distinct Binding Specificities and Functions of Higher Eukaryotic Polypyrimidine Tract-Binding Proteins

1995 • 537 citations

Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

1999 • 506 citations

Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex

1998 • 486 citations

Tau Consists of a Set of Proteins with Repeated C-Terminal Microtubule-Binding Domains and Variable N-Terminal Domains

1989 • 478 citations

The microtubule binding domain of tau protein

1989 • 472 citations

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

1998 • 464 citations

The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing

2001 • 420 citations

Role of the Modular Domains of SR Proteins in Subnuclear Localization and Alternative Splicing Specificity

1997 • 405 citations

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.

1991 • 338 citations

Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.

1998 • 334 citations

A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.

1997 • 324 citations

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains.

1989 • 321 citations

Cooperative Assembly of an hnRNP Complex Induced by a Tissue-Specific Homolog of Polypyrimidine Tract Binding Protein

2000 • 312 citations

Htra2-β 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 ( SMN2 )

2000 • 310 citations

Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family.

1989 • 306 citations

5′ Splice Site Mutations in tau Associated with the Inherited Dementia FTDP-17 Affect a Stem-Loop Structure That Regulates Alternative Splicing of Exon 10

1999 • 294 citations

Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.

1995 • 282 citations

Tau Is Enriched on Dynamic Microtubules in the Distal Region of Growing Axons

1996 • 259 citations

The Neuronal RNA Binding Protein Nova-1 Recognizes Specific RNA Targets In Vitro and In Vivo

1997 • 258 citations

Mechanisms of Alternative Pre-mRNA Splicing

1991 • 257 citations

Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.

1993 • 241 citations

Tau Binds to the Distal Axon Early in Development of Polarity in a Microtubule- and Microfilament-Dependent Manner

1996 • 238 citations

Identification of a New Class of Exonic Splicing Enhancers by In Vivo Selection

1997 • 237 citations

A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing

2000 • 231 citations

hnRNP A1 Recruited to an Exon In Vivo Can Function as an Exon Splicing Silencer

1999 • 219 citations

Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice

2000 • 210 citations

FTDP‐17 mutations N279K and S305N in tau produce increased splicing of exon 10

1999 • 203 citations

Post-transcriptional regulation: The dawn of PTB

1997 • 202 citations

Co-transcriptional commitment to alternative splice site selection

1998 • 195 citations

The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo.

1994 • 186 citations

hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1

2002 • 184 citations

Dynamic Antagonism between ETR-3 and PTB Regulates Cell Type-Specific Alternative Splicing

2002 • 184 citations

Cell Type-Specific Expression of hnRNP Proteins

1995 • 177 citations

Tau gene mutations: dissecting the pathogenesis of FTDP-17

2002 • 174 citations

Regulation of alternative 3' splice site selection by constitutive splicing factors.

1995 • 170 citations

Identification of Positive and Negative Splicing Regulatory Elements within the Terminal tat-rev Exon of Human Immunodeficiency Virus Type 1

1995 • 162 citations

Tau and transgenic animal models

2001 • 160 citations

A novel bipartite splicing enhancer modulates the differential processing of the human fibronectin EDA exon

1994 • 144 citations

SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2beta1

2002 • 134 citations

Splicing Regulation in Neurons: Tinkering with Cell-Specific Control

1998 • 129 citations

Determinants of 4-Repeat Tau Expression

2000 • 129 citations

Amount of RNA secondary structure required to induce an alternative splice.

1987 • 128 citations

Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia

2003 • 125 citations

Thymocytes in Thy-1−/− mice show augmented TCR signaling and impaired differentiation

1997 • 123 citations

An Intron Element Modulating 5′ Splice Site Selection in the hnRNP A1 Pre-mRNA Interacts with hnRNP A1

1997 • 123 citations

RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing

2000 • 122 citations

A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau.

1993 • 119 citations

Regulation of Alternative Splicing of Human Tau Exon 10 by Phosphorylation of Splicing Factors

2001 • 109 citations

Mutations in Tau Gene Exon 10 Associated with FTDP-17 Alter the Activity of an Exonic Splicing Enhancer to Interact with Tra2β

2003 • 107 citations

HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding

2003 • 105 citations

Complex Regulation of Tau Exon 10, Whose Missplicing Causes Frontotemporal Dementia

2000 • 88 citations

Human Transformer-2-beta Gene (SFRS10): Complete Nucleotide Sequence, Chromosomal Localization, and Generation of a Tissue-Specific Isoform

1998 • 87 citations

Multiple Interdependent Sequence Elements Control Splicing of a Fibroblast Growth Factor Receptor 2 Alternative Exon

1997 • 86 citations

tau Exon 10 Expression Involves a Bipartite Intron 10 Regulatory Sequence and Weak 5′ and 3′ Splice Sites

2002 • 84 citations

The Exon Splicing Silencer in Human Immunodeficiency Virus Type 1 Tat Exon 3 Is Bipartite and Acts Early in Spliceosome Assembly

1998 • 82 citations

Developmental changes of tau protein and mRNA in cultured rat brain oligodendrocytes

2001 • 81 citations

Defects in Pre-mRNA Processing as Causes of and Predisposition to Diseases

2002 • 80 citations

Microtubule-associated proteins (MAPs) in the peripheral nervous system during development and regeneration

1997 • 80 citations

Microfilament‐associated growth cone component depends upon Tau for its intracellular localization

1994 • 74 citations

Frontotemporal Dementia: Its Rediscovery

1997 • 73 citations

Polypyrimidine Track-binding Protein Binding Downstream of Caspase-2 Alternative Exon 9 Represses Its Inclusion

2001 • 68 citations

The exon sequence TAGG can inhibit splicing

1996 • 66 citations

Splicing of a Regulated Exon Reveals Additional Complexity in the Axonal Microtubule‐Associated Protein Tau

1998 • 64 citations

A genomic sequence analysis of the mouse and human microtubule-associated protein tau

2001 • 63 citations

SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation

1999 • 63 citations

Elements regulating an alternatively spliced exon of the rat fibronectin gene.

1993 • 62 citations

The Mammalian Homolog of Suppressor-of-white-apricot Regulates Alternative mRNA Splicing of CD45 Exon 4 and Fibronectin IIICS

1996 • 54 citations

Novel Tau Polymorphisms, Tau Haplotypes, and Splicing in Familial and Sporadic Frontotemporal Dementia

2003 • 49 citations

Prediction and Statistical Analysis of Alternatively Spliced Exons

2003 • 46 citations

Novel Exonic Elements That Modulate Splicing of the Human Fibronectin EDA Exon

1997 • 42 citations

Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot.

1994 • 41 citations

Human transformer 2β and SRp55 interact with a calcitonin-specific splice enhancer

2003 • 39 citations

Modulation of the membrane-binding domain of tau protein: splicing regulation of exon 2

2003 • 34 citations

Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3

2002 • 27 citations

Cis-elements involved in alternative splicing in the rat β-tropomyosin gene: the 3′-splice site of the skeletal muscle exon 7 is the major site of blockage in nonmuscle cells

1993 • 24 citations

The exon trapping assay partly discriminates against alternatively spliced exons

1993 • 23 citations

Chromosome 17-linked dementias

1998 • 20 citations