The Neuronal Microtubule‐Associated Protein Tau Is a Substrate for Caspase‐3 and an Effector of Apoptosis

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis

1997 • 1,233 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Tau in Alzheimer's disease

1998 • 936 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

1999 • 777 citations

Tau protein pathology in neurodegenerative diseases

1998 • 674 citations

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

1999 • 641 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1996 • 580 citations

Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract

1998 • 569 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

1998 • 484 citations

Caspase-8 Is Required for Cell Death Induced by Expanded Polyglutamine Repeats

1999 • 418 citations

DNA damage and apoptosis in Alzheimer's disease: colocalization with c- Jun immunoreactivity, relationship to brain area, and effect of postmortem delay

1996 • 400 citations

Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament.

1993 • 374 citations

Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch

1998 • 360 citations

Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

1997 • 353 citations

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.

1995 • 347 citations

Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.

1996 • 298 citations

Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases.

1995 • 265 citations

Actin cleavage by CPP-32/apopain during the development of apoptosis

1997 • 251 citations

Tau Cleavage and Dephosphorylation in Cerebellar Granule Neurons Undergoing Apoptosis

1998 • 233 citations

Dismantling Cell–Cell Contacts during Apoptosis Is Coupled to a Caspase-dependent Proteolytic Cleavage of β-Catenin

1997 • 232 citations

Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51.

1991 • 214 citations

Proteolytic Processing of the Alzheimer's Disease Amyloid Precursor Protein within Its Cytoplasmic Domain by Caspase-like Proteases

1999 • 172 citations

The τ Protein in Human Cerebrospinal Fluid in Alzheimer's Disease Consists of Proteolytically Derived Fragments

1997 • 165 citations

Presenilins Are Processed by Caspase-type Proteases

1997 • 155 citations

Increased Production of Amyloid Precursor Protein Provides a Substrate for Caspase-3 in Dying Motoneurons

1998 • 134 citations

Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype.

1996 • 115 citations

Cytosolic Proteolysis of τ by Cathepsin D in Hippocampus Following Suppression of Cathepsins B and L

1996 • 103 citations

Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines

1998 • 101 citations

Bcl-xL overexpression inhibits taxol-induced Yama protease activity and apoptosis.

1996 • 88 citations

Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF‐tau

1995 • 70 citations

The microtubule-associated protein tau forms a triple-stranded left-hand helical polymer.

1991 • 66 citations

Huntington disease: new insights into the relationship between CAG expansion and disease

1996 • 64 citations

Identification of caspases that cleave presenilin‐1 and presenilin‐2

1999 • 56 citations

Cell and molecular neurobiology of presenilins: A role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?

1997 • 54 citations

Caspase activity sows the seeds of neuronal death

1999 • 39 citations

Co-localization of truncated tau and DNA fragmentation in Alzheimerʼs disease neurones

1997 • 37 citations

The solution structure of theC-terminal segment of tau protein

2000 • 16 citations