Tau isoforms which contain the domain encoded by exon 6 and their role in neurite elongation

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Sequential Treatment of SH‐SY5Y Cells with Retinoic Acid and Brain‐Derived Neurotrophic Factor Gives Rise to Fully Differentiated, Neurotrophic Factor‐Dependent, Human Neuron‐Like Cells

2000 • 759 citations

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

1999 • 701 citations

Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

1990 • 638 citations

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain.

1995 • 601 citations

Developmentally regulated expression of specific tau sequences

1989 • 589 citations

Structure and novel exons of the human .tau. gene

1992 • 587 citations

Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

1992 • 569 citations

Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

1999 • 506 citations

Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice

2001 • 495 citations

Tau Consists of a Set of Proteins with Repeated C-Terminal Microtubule-Binding Domains and Variable N-Terminal Domains

1989 • 478 citations

The microtubule binding domain of tau protein

1989 • 472 citations

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

1998 • 464 citations

Tau interacts with src-family non-receptor tyrosine kinases

1998 • 441 citations

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

1997 • 438 citations

Microtubule organization and dynamics dependent on microtubule-associated proteins

1994 • 411 citations

Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes.

1995 • 366 citations

Alternative RNA splicing in the nervous system

2001 • 331 citations

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains.

1989 • 321 citations

Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family.

1989 • 306 citations

Tau domains, phosphorylation, and interactions with microtubules

1995 • 299 citations

5′ Splice Site Mutations in tau Associated with the Inherited Dementia FTDP-17 Affect a Stem-Loop Structure That Regulates Alternative Splicing of Exon 10

1999 • 294 citations

Discussion

1997 • 279 citations

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly.

1997 • 270 citations

Tau Is Enriched on Dynamic Microtubules in the Distal Region of Growing Axons

1996 • 259 citations

Tau Binds to the Distal Axon Early in Development of Polarity in a Microtubule- and Microfilament-Dependent Manner

1996 • 238 citations

Tau Cleavage and Dephosphorylation in Cerebellar Granule Neurons Undergoing Apoptosis

1998 • 233 citations

Primary structure of high molecular weight tau present in the peripheral nervous system.

1992 • 232 citations

Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice

2000 • 210 citations

Proapoptotic Effects of Tau Cleavage Product Generated by Caspase-3

2001 • 206 citations

The Neuronal Microtubule‐Associated Protein Tau Is a Substrate for Caspase‐3 and an Effector of Apoptosis

2000 • 191 citations

The effect of tau antisense oligonucleotides on neurite formation of cultured cerebellar macroneurons

1991 • 189 citations

The Neurite Retraction Induced by Lysophosphatidic Acid Increases Alzheimer's Disease-like Tau Phosphorylation

1999 • 170 citations

The τ Protein in Human Cerebrospinal Fluid in Alzheimer's Disease Consists of Proteolytically Derived Fragments

1997 • 165 citations

Sorting mechanisms of Tau and MAP2 in neurons: Suppressed axonal transit of MAP2 and locally regulated microtubule binding

1995 • 138 citations

A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau.

1993 • 119 citations

Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons

1999 • 90 citations

Complex Regulation of Tau Exon 10, Whose Missplicing Causes Frontotemporal Dementia

2000 • 88 citations

Developmental changes of tau protein and mRNA in cultured rat brain oligodendrocytes

2001 • 81 citations

Microtubule-associated proteins (MAPs) in the peripheral nervous system during development and regeneration

1997 • 80 citations

Microfilament‐associated growth cone component depends upon Tau for its intracellular localization

1994 • 74 citations

Splicing of a Regulated Exon Reveals Additional Complexity in the Axonal Microtubule‐Associated Protein Tau

1998 • 64 citations

A genomic sequence analysis of the mouse and human microtubule-associated protein tau

2001 • 63 citations

Characterization of tau proteins in human neuroblastoma SH-SY5Y cell line

1997 • 53 citations

Aberrant Tau Phosphorylation and Neurite Retraction during NGF Deprivation in PC12 Cells

1997 • 50 citations

Tau Protein Is Hyperphosphorylated in a Site‐Specific Manner in Apoptotic Neuronal PC12 Cells

2000 • 47 citations

τ Regulation of Microtubule‐Microtubule Spacing and Bundling

1994 • 45 citations

Novel isoforms of tau that lack the microtubule‐binding domain

2004 • 42 citations

Characterization of a PC12 cell sub-clone (PC12-c41) with enhanced neurite outgrowth capacity: implications for a modulatory role of high molecular weight tau in neuritogenesis

1993 • 37 citations

A role of P301L tau mutant in anti-apoptotic gene expression, cell cycle and apoptosis

2003 • 31 citations

Pro-apoptotic effects of tau mutations in chromosome 17 frontotemporal dementia and parkinsonism

2000 • 27 citations

The exon trapping assay partly discriminates against alternatively spliced exons

1993 • 23 citations

Age-Related Phosphorylation and Fragmentation Events Influence the Distribution Profiles of Distinct Tau Isoforms in Mouse Brain

1998 • 22 citations

The splicing determinants of a regulated exon in the axonal MAP tau reside within the exon and in its upstream intron

2000 • 21 citations

Functional organization of tau proteins during neuronal differentiation and development.

1995 • 12 citations