Scanning from an independently specified branch point defines the 3′ splice site of mammalian introns

A catalogue of splice junction sequences

1982 • 3,861 citations

SPLICING OF MESSENGER RNA PRECURSORS

1986 • 1,233 citations

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

PRE-mRNA SPLICING

1986 • 673 citations

The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing

1987 • 594 citations

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

1985 • 568 citations

A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly

1988 • 535 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

A multicomponent complex is involved in the splicing of messenger RNA precursors

1985 • 451 citations

The "Spliceosome": Yeast Pre-Messenger RNA Associates with a 40 S Complex in a Splicing-Dependent Reaction

1985 • 421 citations

Intron sequences involved in lariat formation during pre-mRNA splicing

1985 • 402 citations

Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA

1986 • 389 citations

Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.

1984 • 342 citations

Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast

1984 • 339 citations

A minimal intron length but no specific internal sequence is required for splicing the large rabbit β-globin intron

1984 • 328 citations

Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.

1989 • 314 citations

The 3′ Splice Site of Pre-Messenger RNA Is Recognized by a Small Nuclear Ribonucleoprotein

1985 • 310 citations

A compensatory base change in human U2 snRNA can suppress a branch site mutation.

1989 • 284 citations

A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of premessenger RNA

1986 • 283 citations

A protein that specifically recognizes the 3′ splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein

1986 • 274 citations

RNA binding specificity of hnRNP proteins: a subset bind to the 3′ end of introns.

1988 • 251 citations

Signals for the selection of a splice site in pre-mRNA

1987 • 247 citations

Mutually exclusive splicing of α-tropomyosin exons enforced by an unusual lariat branch point location: Implications for constitutive splicing

1989 • 238 citations

Base substitution in an intervening sequence of a beta+-thalassemic human globin gene.

1981 • 236 citations

Cryptic branch point activation allows accurate in vitro splicing of human β-globin intron mutants

1985 • 236 citations

The role of the mammalian branchpoint sequence in pre-mRNA splicing.

1988 • 215 citations

Role of the 3′ splice site consensus sequence in mammalian pre-mRNA splicing

1985 • 184 citations

UACUAAC is the preferred branch site for mammalian mRNA splicing.

1989 • 180 citations

Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing

1985 • 180 citations

Trans splicing of mrna precursors in vitro

1985 • 180 citations

A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation.

1987 • 179 citations

Splice site selection and ribonucleoprotein complex assembly during in vitro pre-mRNA splicing.

1988 • 163 citations

The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA

1986 • 148 citations

A point mutation in the conserved hexanucleotide at a yeast 5′ splice junction uncouples recognition, cleavage, and ligation

1985 • 129 citations

Cleavage of 5′ splice site and lariat formation are independent of 3′ splice site in yeast mRNA splicing

1985 • 122 citations

The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3′ splice site in alternative splicing.

1988 • 105 citations

Nonconsensus branch-site sequences in the in vitro splicing of transcripts of mutant rabbit beta-globin genes.

1985 • 96 citations

Branch point selection in alternative splicing of tropomyosin pre-mRNAs

1989 • 89 citations

Unusual branch point selection in processing of human growth hormone pre-mRNA.

1988 • 72 citations

Genetic cause of a Juvenile Form of Sandhoff Disease

1989 • 63 citations

Inhibition of splicing but not cleavage at the 5' splice site by truncating human beta-globin pre-mRNA.

1986 • 58 citations

Yeast pre-messenger RNA splicing efficiency depends on critical spacing requirements between the branch point and 3′ splice site.

1986 • 53 citations

Beta zero thalassemia caused by a base substitution that creates an alternative splice acceptor site in an intron.

1986 • 52 citations

Multiple cis-acting sequence elements are required for efficient splicing of simian virus 40 small-t antigen pre-mRNA.

1988 • 51 citations

Short donor site sequences inserted within the intron of beta-globin pre-mRNA serve for splicing in vitro.

1988 • 36 citations

Impairment of yeast pre-mRNA splicing by potential secondary structure-forming sequences near the conserved branchpoint sequence

1988 • 26 citations

Deletion analysis of a unique 3' splice site indicates that alternating guanine and thymine residues represent an efficient splicing signal

1987 • 22 citations