Mutations in Tau Gene Exon 10 Associated with FTDP-17 Alter the Activity of an Exonic Splicing Enhancer to Interact with Tra2β

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Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

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RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

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Neurodegenerative Tauopathies

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Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

Sorting out the complexity of SR protein functions

2000 • 1,064 citations

Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

1998 • 954 citations

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

1992 • 936 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

1977 • 834 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

1993 • 741 citations

Tau protein function in living cells.

1986 • 727 citations

Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases

2000 • 689 citations

The superfamily of arginine/serine-rich splicing factors.

1995 • 671 citations

SR proteins and splicing control.

1996 • 668 citations

Structure and novel exons of the human .tau. gene

1992 • 587 citations

Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

1999 • 506 citations

Pre-mRNA splicing in the new millennium

2001 • 477 citations

Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assembly

1998 • 469 citations

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

1998 • 464 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

High Prevalence of Mutations in the Microtubule-Associated Protein Tau in a Population Study of Frontotemporal Dementia in the Netherlands

1999 • 419 citations

Frontotemporal Dementia and Corticobasal Degeneration in a Family with a P301S Mutation in Tau

1999 • 418 citations

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.

1989 • 354 citations

Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments

1997 • 334 citations

5′ Splice Site Mutations in tau Associated with the Inherited Dementia FTDP-17 Affect a Stem-Loop Structure That Regulates Alternative Splicing of Exon 10

1999 • 294 citations

Accelerated filament formation from tau protein with specific FTDP‐17 missense mutations

1999 • 285 citations

Tau Pathology in Two Dutch Families with Mutations in the Microtubule-Binding Region of Tau

1998 • 281 citations

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly.

1997 • 270 citations

Filamentous nerve cell inclusions in neurodegenerative diseases

1998 • 261 citations

Segregation of a Missense Mutation in the Microtubule-Associated Protein Tau Gene with Familial Frontotemporal Dementia and Parkinsonism

1998 • 236 citations

Functional organization of microtubule-associated protein tau. Identification of regions which affect microtubule growth, nucleation, and bundle formation in vitro.

1993 • 219 citations

Structural and Functional Differences between 3-Repeat and 4-Repeat Tau Isoforms

2000 • 218 citations

Human Tra2 Proteins Are Sequence-Specific Activators of Pre-mRNA Splicing

1998 • 212 citations

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

1999 • 207 citations

FTDP‐17 mutations N279K and S305N in tau produce increased splicing of exon 10

1999 • 203 citations

Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer

1997 • 192 citations

Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF.

1993 • 192 citations

Finding splice sites within a wilderness of RNA.

1995 • 188 citations

Microtubule bundling by tau proteins in vivo: analysis of functional domains.

1992 • 186 citations

Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways.

1995 • 174 citations

Familial atypical progressive supranuclear palsy associated with homozigosity for the delN296 mutation in the tau gene

2001 • 161 citations

TauGene Mutation K257T Causes a Tauopathy Similar to Pick's Disease

2000 • 160 citations

Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles

1996 • 157 citations

A distinct familial presenile dementia with a novel missense mutation in the tau gene

1999 • 156 citations

Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors

1998 • 144 citations

A noveltau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies

2000 • 137 citations

SR-related proteins and the processing of messenger RNA precursors

1999 • 133 citations

Aberrant Splicing of tau Pre-mRNA Caused by Intronic Mutations Associated with the Inherited Dementia Frontotemporal Dementia with Parkinsonism Linked to Chromosome 17

2000 • 131 citations

Pick's disease associated with the novel Tau gene mutation K369I

2001 • 129 citations

An Intron Element Modulating 5′ Splice Site Selection in the hnRNP A1 Pre-mRNA Interacts with hnRNP A1

1997 • 123 citations

A novel mutation at position +12 in the intron following Exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto)

2000 • 109 citations

The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites.

1994 • 107 citations

The ‘jaws’ model of tau-microtubule interaction examined in CHO cells

1997 • 101 citations

Frontotemporal dementia with novel tau pathology and a Glu342Valtau mutation

2000 • 93 citations

Familial frontotemporal dementia and parkinsonism with a novel N296H mutation in exon 10 of the tau gene and a widespread tau accumulation in the glial cells

2001 • 92 citations

A novel tau mutation, S320F, causes a tauopathy with inclusions similar to those in Pick's disease

2002 • 90 citations

Complex Regulation of Tau Exon 10, Whose Missplicing Causes Frontotemporal Dementia

2000 • 88 citations

Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics

2000 • 86 citations

Ischemia Induces a Translocation of the Splicing Factor tra2-β1 and Changes Alternative Splicing Patterns in the Brain

2002 • 86 citations

Localization of frontotemporal dementia with parkinsonism in an Australian kindred to chromosome 17q21–22

1997 • 82 citations

Missense tau mutations identified in FTDP-17 have a small effect on tau–microtubule interactions

2000 • 80 citations

Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10+11‐splice site in the tau gene

2001 • 79 citations

Identification of a Bidirectional Splicing Enhancer: Differential Involvement of SR Proteins in 5′ or 3′ Splice Site Activation

1999 • 78 citations

Molecular Cloning of htra2-beta-1 and htra2-beta-2, Two Human Homologs oftra-2Generated by Alternative Splicing

1997 • 76 citations

Caspase-2 pre-mRNA alternative splicing: Identification of an intronic element containing a decoy 3′ acceptor site

2001 • 68 citations

Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway

2001 • 62 citations

A new case of frontotemporal dementia and parkinsonism resulting from an intron 10 +3‐splice site mutation in the tau gene: clinical and pathological features

2000 • 42 citations

Exonic splicing enhancers contribute to the use of both 3′ and 5′ splice site usage of rat β-tropomyosin pre-mRNA

1999 • 40 citations

Pre-mRNA Splicing by the Essential Drosophila Protein B52: Tissue and Target Specificity

2000 • 31 citations

Construction of 4-Thiouridine Site-Specifically Substituted RNAs for Cross-Linking Studies

1999 • 28 citations

An element in the 5' common exon of the NCAM alternative splicing unit interacts with SR proteins and modulates 5' splice site selection

1999 • 25 citations

Uncoupling two functions of the U1 small nuclear ribonucleoprotein particle during in vitro splicing.

1993 • 23 citations