Modest cortex and promiscuous medulla for thymic repertoire formation

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

Proteasome inhibitors: from research tools to drug candidates

2001 • 1,159 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

CHEMOKINES, SPHINGOSINE-1-PHOSPHATE, AND CELL MIGRATION IN SECONDARY LYMPHOID ORGANS

2004 • 840 citations

The development of proteasome inhibitors as anticancer drugs

2004 • 768 citations

A CENTRAL ROLE FOR CENTRAL TOLERANCE

2006 • 730 citations

Journey through the thymus: stromal guides for T-cell development and selection

2006 • 690 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

Antigen processing by the proteasome

2001 • 620 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

Regulation of CD8 ⁺ T Cell Development by Thymus-Specific Proteasomes

2007 • 528 citations

MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

1994 • 520 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Zoned Out: Functional Mapping of Stromal Signaling Microenvironments in the Thymus

2007 • 436 citations

Launching the T-cell-lineage developmental programme

2007 • 433 citations

Lysosomal cysteine proteases regulate antigen presentation

2003 • 428 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

2007 • 367 citations

How the T Cell Repertoire Becomes Peptide and MHC Specific

2005 • 310 citations

The MHC class I ligand‐generating system: roles of immunoproteasomes and the interferon‐4gMY‐inducible proteasome activator PA28

1998 • 288 citations

Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Central tolerance: good but imperfect

2006 • 196 citations

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

2008 • 191 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

Cathepsin L Regulates CD4+ T Cell Selection Independently of Its Effect on Invariant Chain

2002 • 186 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

Transcription of a Broad Range of Self-Antigens in Human Thymus Suggests a Role for Central Mechanisms in Tolerance Toward Peripheral Antigens

1998 • 173 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

Intrathymic Expression of Genes Involved in Organ Specific Autoimmune Disease

1998 • 155 citations

Thymic microenvironments for T cell differentiation and selection

2006 • 154 citations

Promiscuous expression of tissue antigens in the thymus: a key to T-cell tolerance and autoimmunity?

2000 • 117 citations

Thymoproteasome: probable role in generating positively selecting peptides

2008 • 110 citations

CD4⧸CD8 Coreceptors in Thymocyte Development, Selection, and Lineage Commitment: Analysis of the CD4⧸CD8 Lineage Decision

2004 • 95 citations

Positive selection of T lymphocytes on fibroblasts

1993 • 92 citations

Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein

1995 • 74 citations

Structural studies of class I major histocompatibility complex proteins: insights into antigen presentation

1995 • 61 citations

TCR Signaling for Initiation and Completion of Thymocyte Positive Selection Has Distinct Requirements for Ligand Quality and Presenting Cell Type

2000 • 48 citations

Noninvasive Intravital Imaging of Thymocyte Dynamics in Medaka

2007 • 44 citations

Aberrant Expression of Tissue‐Specific Proteins in the Thymus: A Hypothesis for the Development of Central Tolerance

1998 • 39 citations