Peptide Diffusion, Protection, and Degradation in Nuclear and Cytoplasmic Compartments before Antigen Presentation by MHC Class I

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes

2000 • 1,477 citations

NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase

1998 • 1,184 citations

Studying protein dynamics in living cells

2001 • 1,174 citations

High mobility of proteins in the mammalian cell nucleus

2000 • 1,163 citations

CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

2001 • 1,118 citations

Nuclear Membrane Dynamics and Reassembly in Living Cells: Targeting of an Inner Nuclear Membrane Protein in Interphase and Mitosis

1997 • 753 citations

Lateral diffusion of rhodopsin in the photoreceptor membrane

1974 • 658 citations

From fixed to FRAP: measuring protein mobility and activity in living cells

2001 • 629 citations

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

2002 • 620 citations

Selective and ATP-Dependent Translocation of Peptides by the MHC-Encoded Transporter

1993 • 556 citations

Diffusional Mobility of Golgi Proteins in Membranes of Living Cells

1996 • 499 citations

Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro

1990 • 418 citations

The major substrates for TAP in vivo are derived from newly synthesized proteins

2000 • 408 citations

A Giant Protease with Potential to Substitute for Some Functions of the Proteasome

1999 • 377 citations

26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

2001 • 322 citations

Injected nuclei in frog oocytes: fate, enlargement, and chromatin dispersal

1976 • 305 citations

Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase

1998 • 297 citations

Dynamics of proteasome distribution in living cells

1997 • 269 citations

Heat Shock Protein-chaperoned Peptides but Not Free Peptides Introduced into the Cytosol Are Presented Efficiently by Major Histocompatibility Complex I Molecules

2001 • 218 citations

Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane.

1995 • 216 citations

Structure determination and refinement of bovine lens leucine aminopeptidase and its complex with bestatin

1992 • 207 citations

Fluorescence recovery after photobleaching: a versatile tool for mobility and interaction measurements in pharmaceutical research.

1999 • 194 citations

Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling.

1994 • 151 citations

Export of Antigenic Peptides from the Endoplasmic Reticulum Intersects with Retrograde Protein Translocation through the Sec61p Channel

2000 • 151 citations

Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing

2001 • 147 citations

Distinct Proteolytic Processes Generate the C and N Termini of MHC Class I-Binding Peptides

1999 • 144 citations

Discrete Proteolytic Intermediates in the MHC Class I Antigen Processing Pathway and MHC I–Dependent Peptide Trimming in the ER

1999 • 123 citations

Efficiency of MHC class I antigen processing: A quantitative analysis

1994 • 121 citations

Kinetics of Peptide Binding to the Bovine 70 kDa Heat Shock Cognate Protein, a Molecular Chaperone

1996 • 81 citations

Efficient MHC Class I-Independent Amino-Terminal Trimming of Epitope Precursor Peptides in the Endoplasmic Reticulum

2001 • 74 citations

Identification of Novel Peptide Binding Proteins in the Endoplasmic Reticulum: ERp72, Calnexin, and grp170

1999 • 70 citations

The rational design of TAP inhibitors using peptide substrate modifications and peptidomimetics

1997 • 49 citations

Proteasome activity limits the assembly of MHC class I molecules after IFN-gamma stimulation.

1997 • 46 citations

Intracellular Rate-Limiting Steps in MHC Class I Antigen Processing

1999 • 40 citations

Immunosuppression By D-Isomers Of Hla Class I Heavy Chain (Amino Acid 75 To 84)-Derived Peptides Is Independent Of Binding To Hsc70

1997 • 23 citations

Mobility of creatine phosphokinase and beta-enolase in cultured muscle cells

1997 • 13 citations