Cathepsin L Regulates CD4+ T Cell Selection Independently of Its Effect on Invariant Chain

CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES

1997 • 779 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

The T Cell Receptor

1987 • 554 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.

1981 • 531 citations

Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

1996 • 523 citations

Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development

1999 • 519 citations

Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice

1999 • 408 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Invariant Chain Structure and MHC Class II Function

1996 • 374 citations

An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation

1998 • 362 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Article

1995 • 325 citations

Cathepsin S activity regulates antigen presentation and immunity.

1998 • 307 citations

Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation

1998 • 266 citations

Proteases involved in MHC dass II antigen presentation

1999 • 235 citations

Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E

1992 • 207 citations

Cathepsins and compartmentalization in antigen presentation

2000 • 204 citations

Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire

1997 • 198 citations

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells.

1984 • 190 citations

Degradation of Mouse Invariant Chain: Roles of Cathepsins S and D and the Influence of Major Histocompatibility Complex Polymorphism

1997 • 188 citations

Endosomal aspartic proteinases are required for invariant-chain processing.

1994 • 182 citations

Proteolysis in MHC Class II Antigen Presentation

2000 • 181 citations

The role of lysosomal proteinases in MHC class Il‐mediated antigen processing and presentation

1999 • 179 citations

A Role for Cathepsin L and Cathepsin S in Peptide Generation for MHC Class II Presentation

2002 • 175 citations

T-cell selection

1998 • 168 citations

Requirement for Diverse, Low-Abundance Peptides in Positive Selection of T Cells

1999 • 151 citations

Control of Antigen Presentation by a Single Protease Cleavage Site

2000 • 150 citations

Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody

1982 • 145 citations

The Imprint of Intrathymic Self-Peptides on the Mature T Cell Receptor Repertoire

1997 • 105 citations

Role of cathepsin D in antigen presentation of ovalbumin.

1992 • 93 citations

MHC class II antigen processing: biology of invariant chain

1994 • 83 citations

Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms

1995 • 80 citations

The p41 isoform of invariant chain is a chaperone for cathepsin L

2001 • 76 citations

Cathepsin D, but not cathepsin B, releases T cell stimulatory fragments from lysozyme that are functional in the context of multiple murine class II MHC molecules

1994 • 62 citations

Invariant Chain–independent Function of H-2M in the Formation of Endogenous Peptide–Major Histocompatibility Complex Class II Complexes In Vivo

1998 • 60 citations

T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates.

1995 • 58 citations

Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes

1997 • 45 citations

Competition for Specific Intrathymic Ligands Limits Positive Selection in a TCR Transgenic Model of CD4+ T Cell Development

2000 • 39 citations

Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain

1995 • 36 citations

The CD4 T cell-deficient mouse mutation nackt ( nkt ) involves a deletion in the cathepsin L ( Ctsl ) gene

2001 • 34 citations

The use of benzyloxycarbonyl[125I]iodotyrosylalanyldiazomethane as a probe for active cysteine proteinases in human tissues

1989 • 31 citations

Distinct Peptide Loading Pathways for MHC Class II Molecules Associated with Alternative Ii Chain Isoforms

1998 • 24 citations