Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Likelihood-enhanced fast translation functions

2005 • 1,648 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

HOW TCRS BIND MHCS, PEPTIDES, AND CORECEPTORS

2006 • 1,227 citations

The somatic generation of immune recognition

1971 • 974 citations

Control of Effector CD8 ⁺ T Cell Function by the Transcription Factor Eomesodermin

2003 • 956 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains

2004 • 803 citations

Macromolecular Crystallography Part A

1997 • 779 citations

IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains

2002 • 751 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Human T-cell receptor variable gene segment families

1995 • 663 citations

The T Cell Receptor

1987 • 554 citations

[10] Electron-density map interpretation

1997 • 501 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

T Cell Selection in the Thymus

1988 • 405 citations

The Crystal Structure of a T Cell Receptor in Complex with Peptide and MHC Class II

1999 • 400 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity

2003 • 326 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

H-2 antigens of the thymus determinelymphocyte specificity

1978 • 321 citations

How the T Cell Repertoire Becomes Peptide and MHC Specific

2005 • 310 citations

A structural basis for immunodominant human T cell receptor recognition

2003 • 300 citations

Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1

2000 • 271 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction

2008 • 262 citations

An inverse relationship between T cell receptor affinity and antigen dose during CD4⁺T cell responsesin vivoandin vitro

1999 • 259 citations

CDR3 loop flexibility contributes to the degeneracy of TCR recognition

2003 • 253 citations

How a Single T Cell Receptor Recognizes Both Self and Foreign MHC

2007 • 236 citations

Retroviral-Mediated Transfer of the Green Fluorescent Protein Gene Into Murine Hematopoietic Cells Facilitates Scoring and Selection of Transduced Progenitors In Vitro and Identification of Genetically Modified Cells In Vivo

1997 • 230 citations

How Many Thymocytes Audition for Selection?

1997 • 222 citations

Structural evidence for a germline-encoded T cell receptor–major histocompatibility complex interaction 'codon'

2007 • 215 citations

Structure of a Complex of the Human α/β T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401)

2002 • 206 citations

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

2007 • 196 citations

Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule

2005 • 181 citations

International Tables for Crystallography

2006 • 167 citations

Deletion of CD4 and CD8 Coreceptors Permits Generation of αβT Cells that Recognize Antigens Independently of the MHC

2007 • 165 citations

Structure of an Autoimmune T Cell Receptor Complexed with Class II Peptide-MHC

2005 • 154 citations

T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α- and β-genes

1988 • 148 citations

Mouse T-cell receptor variable gene segment families

1995 • 138 citations

The T cell repertoire may be biased in favor of MHC recognition

1986 • 121 citations

Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

2006 • 102 citations

Shapes of MHC Restriction

1999 • 100 citations

Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

2002 • 97 citations

A Correlation between TCR Vα Docking on MHC and CD8 Dependence

2003 • 92 citations

Structure of an Autoimmune T Cell Receptor Complexed with Class II Peptide-MHCInsights into MHC Bias and Antigen Specificity

2005 • 91 citations

Antigen recognition properties of mutant V beta 3+ T cell receptors are consistent with an immunoglobulin-like structure for the receptor.

1993 • 89 citations

Comparison of human and mouse T-cell receptor variable gene segment subfamilies

1995 • 81 citations

Alternate interactions define the binding of peptides to the MHC molecule IA^b

2002 • 78 citations

The interaction of nominal antigen with T cell antigen receptors. I. Specific binding of multivalent nominal antigen to cytolytic T cell clones.

1985 • 78 citations

Negative selection imparts peptide specificity to the mature T cell repertoire

2003 • 71 citations

The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state

2002 • 62 citations

What guides MHC-restricted TCR recognition?

2007 • 46 citations