Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

CD1 Recognition by Mouse NK1 ⁺ T Lymphocytes

1995 • 903 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Human T-cell receptor variable gene segment families

1995 • 663 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

A Subset of CD4 ⁺ Thymocytes Selected by MHC Class I Molecules

1994 • 464 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

The effect of thymus environment on T cell development and tolerance

1988 • 330 citations

Production of soluble MHC class II proteins with covalently bound single peptides

1994 • 302 citations

Role of self-peptides in positively selecting the T-cell repertoire

1990 • 300 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

On the complexity of self

1991 • 261 citations

Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.

1983 • 245 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

Intracellular transport of MHC class II molecules

1992 • 222 citations

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

1993 • 221 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells.

1984 • 190 citations

A novel MHC class II epitope expressed in thymic medulla but not cortex

1989 • 175 citations

Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.

1990 • 170 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

Mature T cell reactivity altered by peptide agonist that induces positive selection.

1996 • 148 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Mouse T-cell receptor variable gene segment families

1995 • 138 citations

Positive selection of CD4+ T cells mediated by MHC class ll-bearing stromal cell in the thymic cortex

1989 • 130 citations

The effects of MHC gene dosage and allelic variation on T cell receptor selection

1990 • 123 citations

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes.

1994 • 118 citations

Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells.

1992 • 98 citations

Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity

1994 • 95 citations

A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes.

1994 • 86 citations

Thymic cortical epithelial cells lack full capacity for antigen presentation

1989 • 85 citations

Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms

1995 • 80 citations

Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epithelium.

1993 • 76 citations

Mutations in the major histocompatibility complex class I antigen‐presenting groove affect both negative and positive selection of T cells

1990 • 54 citations

Potent effects of low levels of MHC class II-associated invariant chain on CD4+ T cell development

1995 • 51 citations

Functional interaction between human histocompatibility leukocyte antigen (HLA) class II and mouse CD4 molecule in antigen recognition by T cells in HLA-DR and DQ transgenic mice.

1994 • 31 citations

Modification of the T cell responsiveness to synthetic peptides by substituting amino acids on agretopes

1990 • 27 citations

Differentiation of CD3-4-8- thymocytes in short-term thymic stromal cell culture.

1992 • 23 citations

It is easier for a camel to pass the needle's eye

1992 • 20 citations