On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Epidermal Langerhans cells are derived from cells originating in bone marrow

1979 • 879 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

The Molecular Basis of Allorecognition

1993 • 398 citations

Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H‐2‐Restriction‐Specificity and in H‐2 Linked Ir Gene Control

1978 • 291 citations

The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.

1978 • 268 citations

The Influence of Thymus H-2 Antigens on the Specificity of Maturing Killer and Helper Cells

1978 • 257 citations

T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides

1993 • 256 citations

Thymic Epithelium Tolerizes for Histocompatibility Antigens

1990 • 179 citations

LCMV-Specific, Class II-Restricted Cytotoxic T Cells in β2-Microglobulin-Deficient Mice

1992 • 164 citations

The origin of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes on them

1984 • 160 citations

Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells

1984 • 158 citations

T-cell specificity for H–2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells

1980 • 153 citations

Specificity of cytotoxic T cells from athymic mice.

1980 • 141 citations

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.

1980 • 139 citations

Humoral and cell-mediated immune responses in fully allogeneic bone marrow chimera in mice

1980 • 136 citations

In Thymic Selection, Peptide Diversity Gives and Takes Away

1997 • 136 citations

Inefficient positive selection of T cells directed by haematopoietic cells

1992 • 132 citations

Nude Mice in Immunology

2015 • 114 citations

MHC class I is required for peripheral accumulation of CD8+ thymic emigrants.

1998 • 112 citations

Evidence for a Thymus‐Dependent Form of Tolerance that is Not Based on Elimination or Anergy of Reactive T cells

1996 • 111 citations

Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus

1997 • 108 citations

In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type.

1978 • 108 citations

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

1995 • 104 citations

Positive Selection of Thymocytes

1995 • 103 citations

Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line

1992 • 103 citations

Shapes of MHC Restriction

1999 • 100 citations

MHC Class I Is Required for Peripheral Accumulation of CD8+ Thymic Emigrants

1998 • 100 citations

Positive selection of T lymphocytes on fibroblasts

1993 • 92 citations

A cell line that can induce thymocyte positive selection

1992 • 91 citations

T cell antigen receptor expression in athymic (nu/nu) mice. Evidence for an oligoclonal beta chain repertoire.

1987 • 81 citations

Vaccinia-specific cytotoxic T-cell responses in the context of H-2 antigens not encountered in thymus may reflect aberrant recognition of a virus-H-2 complex.

1979 • 80 citations

Immune restoration by fetal pig thymus grafts in T cell-depleted, thymectomized mice.

1997 • 78 citations

Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.

1982 • 58 citations

Thymic epithelium tolerizes for histocompatibility antigens

1990 • 53 citations

Why Positive Selection?

1993 • 52 citations

Bone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.

1985 • 46 citations

Characterization of V_β‐bearing cells in athymic (nu/nu) mice suggests an extrathymic pathway for T cell differentiation

1990 • 41 citations

Allo- and self-restricted cytotoxic T lymphocytes against a peptide library: evidence for a functionally diverse allorestricted T cell repertoire

1998 • 40 citations

Extrathymic positive selection of αβ T-cell precursors in nude mice

1992 • 36 citations

Differences in the MHC-restricted self-recognition repertoire of intra-thymic and extra-thymic cytotoxic T lymphocyte precursors.

1983 • 32 citations

T cell‐mediated cytotoxic immune responsiveness of chimeric mice bearing a thymus graft fully allogeneic to the graft of lymphoid stem cells

1980 • 31 citations

Thymic reconstitution of nude F1 mice with one or both parental thymus grafts

1979 • 30 citations

K-252a specifically inhibits the survival and morphological differentiation of NGF-dependent neurons in primary cultures of human dorsal root ganglia

1989 • 28 citations

Experimentation and thymic selection.

1988 • 19 citations

Affinity Maturation of Lymphocyte Receptors and Positive Selection of T Cells in the Thymus

1993 • 19 citations

Restoration of Thymic Function in Neonatally Thymectomized Mice Bearing Xenogeneic Thymic Grafts

1966 • 17 citations

Anti‐viral immune response of allogeneic irradiation bone marrow chimeras: cytotoxic T cell responsiveness depends upon H‐2 combination and infectious agent

1984 • 14 citations