How the T Cell Repertoire Becomes Peptide and MHC Specific

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

Antigen-Presenting Function of the Macrophage

1984 • 1,164 citations

The somatic generation of immune recognition

1971 • 974 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex

2003 • 816 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis

2001 • 650 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.

1992 • 326 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex

1975 • 276 citations

Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice

1995 • 273 citations

How T cells 'see' antigen

2005 • 257 citations

How Many Thymocytes Audition for Selection?

1997 • 222 citations

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

1989 • 219 citations

Back to Central Tolerance

2004 • 202 citations

Thymic selection revisited: how essential is it?

2003 • 186 citations

Positive selection of CD4+ thymocytes controlled by MHC class II gene products

1988 • 174 citations

Control of MHC Restriction by TCR V _α CDR1 and CDR2

1996 • 152 citations

The T cell repertoire may be biased in favor of MHC recognition

1986 • 121 citations

What do TCR–pMHC crystal structures teach us about MHC restriction and alloreactivity?

2003 • 121 citations

Age-Dependent T Cell Tolerance and Autoimmunity to Myelin Basic Protein

2001 • 109 citations

Alternate interactions define the binding of peptides to the MHC molecule IA^b

2002 • 78 citations

Mimotopes for Alloreactive and Conventional T Cells in a Peptide–MHC Display Library

2004 • 74 citations

Negative selection imparts peptide specificity to the mature T cell repertoire

2003 • 71 citations

Why Positive Selection?

1993 • 52 citations

Characterization of an Lyt-2+ alloreactive cytotoxic T cell clone specific for H-2Db that cross-reacts with I-Ek.

1986 • 35 citations

CD4 T cells can reject major histocompatibility complex class I-incompatible skin grafts

1999 • 29 citations