Cytosolic Ca2+Changes duringIn VitroIschemia in Rat Hippocampal Slices: Major Roles for Glutamate and Na+-Dependent Ca2+Release from Mitochondria

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Assessment of Fura-2 for measurements of cytosolic free calcium

1990 • 453 citations

Intracellular and extracellular changes of [Ca2+] in hypoxia and ischemia in rat brain in vivo.

1990 • 386 citations

Imaging of synaptically evoked intrinsic optical signals in hippocampal slices

1991 • 302 citations

Imaging cell volume changes and neuronal excitation in the hippocampal slice

1994 • 302 citations

High-resolution immunogold localization of AMPA type glutamate receptor subunits at synaptic and non-synaptic sites in rat hippocampus

1995 • 292 citations

Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury

1991 • 265 citations

Mechanisms involved in irreversible anoxic damage to the in vitro rat hippocampal slice

1982 • 261 citations

The N-methyl-D-aspartate antagonist, MK-801, fails to protect against neuronal damage caused by transient, severe forebrain ischemia in adult rats

1991 • 239 citations

Calcium-related damage in ischemia

1996 • 193 citations

Dendritic Na+ channels amplify EPSPs in hippocampal CA1 pyramidal cells

1996 • 192 citations

Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia

1988 • 192 citations

Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones.

1997 • 185 citations

A Role for Calcium Influx in the Regulation of Mitochondrial Calcium in Endothelial Cells

1996 • 183 citations

Selectivity of Inhibition of Na+-Ca2+ Exchange of Heart Mitochondria by Benzothiazepine CGP-37157

1993 • 182 citations

Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low-affinity fluorescent calcium indicators.

1997 • 169 citations

Effects of membrane depolarization on light scattering by cerebral cortical slices

1973 • 163 citations

ZK200775: A phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma

1998 • 162 citations

Na+ currents that fail to inactivate

1993 • 160 citations

Focal and Perifocal Changes in Tissue Energy State during Middle Cerebral Artery Occlusion in Normo- and Hyperglycemic Rats

1992 • 156 citations

Ionized Intracellular Calcium Concentration Predicts Excitotoxic Neuronal Death: Observations with Low-Affinity Fluorescent Calcium Indicators

1997 • 149 citations

The effect of the NMDA receptor antagonist MK-801 on cerebral blood flow and infarct volume in experimental focal stroke

1992 • 142 citations

Origin of intracellular Ca2+ elevation induced by in vitro ischemia-like condition in hippocampal slices

1993 • 132 citations

Intracellular calcium levels and calcium fluxes in the CA1 region of the rat hippocampal slice during in vitro ischemia: relationship to electrophysiological cell damage

1993 • 128 citations

In VitroIschemia Promotes Glutamate-Mediated Free Radical Generation and Intracellular Calcium Accumulation in Hippocampal Pyramidal Neurons

1997 • 127 citations

Damage from oxygen and glucose deprivation in hippocampal slices is prevented by tetrodotoxin, lidocaine and phenytoin without blockade of action potentials

1994 • 119 citations

Mechanism of glutamate release from rat hippocampal slices during in vitro ischemia

1996 • 111 citations

Causes of calcium accumulation in rat cortical brain slices during hypoxia and ischemia: role of ion channels and membrane damage

1994 • 111 citations

Hippocampal slices: glutamate overflow and cellular damage from ischemia are reduced by sodium-channel blockade

1995 • 101 citations

σ-Ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia

1990 • 95 citations

Oxygen/Glucose Deprivation in Hippocampal Slices: Altered Intraneuronal Elemental Composition Predicts Structural and Functional Damage

1999 • 92 citations

The importance of sodium for anoxic transmission damage in rat hippocampal slices: mechanisms of protection by lidocaine.

1995 • 89 citations

Cellular mechanisms involved in brain ischemia

1995 • 87 citations

Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion.

1994 • 81 citations

CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons

1997 • 73 citations

Increased intracellular Ca2+ concentration in the hippocampal CA1 area during global ischemia and reperfusion in the rat: a possible cause of delayed neuronal death

1999 • 60 citations

The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons following transient severe forebrain ischaemia in rats. A microdialysis and histological study

1993 • 55 citations

Lidocaine protects hippocampal neurons against ischemic damage by preventing increase of extracellular excitatory amino acids: a microdialysis study in Mongolian gerbils

1994 • 55 citations

Protection from neuronal damage induced by combined oxygen and glucose deprivation in organotypic hippocampal cultures by glutamate receptor antagonists

1995 • 51 citations

Neuroprotective Effect of YM90K, a Novel AMPA/Kainate Receptor Antagonist, in Focal Cerebral Ischemia in Cats

1996 • 48 citations

Continuous monitoring and regulating of brain temperature in the conscious and freely moving ischemic gerbil: Effect of MK-801 on delayed neuronal death in hippocampal CA1

1997 • 48 citations

Relationships between ions and energy metabolism: cerebral calcium movements during ischaemia and subsequent recovery

1992 • 37 citations

Ca2+- and Cl−-dependent, NMDA receptor-mediated neuronal death induced by depolarization in rat hippocampal organotypic cultures

1995 • 31 citations

Anoxia reduces depolarization induced calcium uptake in the rat hippocampal slice

1994 • 12 citations

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