Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress–induced death of motor neurons in amyotrophic lateral sclerosis

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1995 • 1,430 citations

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1995 • 1,424 citations

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

2001 • 1,083 citations

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

1997 • 792 citations

Natural history of amyotrophic lateral sclerosis in a database population Validation of a scoring system and a model for survival prediction

1995 • 683 citations

Benefit of vitamin E, riluzole, and gababapentin in a transgenic model of familial amyotrophic lateral sclerosis

1996 • 654 citations

Serine Palmitoyltransferase Is the Primary Target of a Sphingosine-like Immunosuppressant, ISP-1/Myriocin

1995 • 537 citations

Epidemiology of mutations in superoxide dismutase in amyotrophic lateal sclerosis

1997 • 517 citations

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide

2001 • 462 citations

Direct Inhibition of Mitochondrial Respiratory Chain Complex III by Cell-permeable Ceramide

1997 • 442 citations

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS)

1995 • 435 citations

Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro.

1996 • 420 citations

Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I

2001 • 409 citations

Lipoapoptosis in Beta-cells of Obese Prediabeticfa/fa Rats

1998 • 386 citations

Protein modification by the lipid peroxidation product 4‐hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

1998 • 382 citations

Motor Neurons Are Selectively Vulnerable to AMPA/Kainate Receptor-Mediated InjuryIn Vitro

1996 • 368 citations

Structural determination of picomole amounts of phospholipids via electrospray ionization tandem mass spectrometry

1995 • 288 citations

ALS-Linked Cu/Zn–SOD Mutation Increases Vulnerability of Motor Neurons to Excitotoxicity by a Mechanism Involving Increased Oxidative Stress and Perturbed Calcium Homeostasis

1999 • 254 citations

Sphingolipids in Atherosclerosis and Vascular Biology

1998 • 242 citations

Pivotal Role for Acidic Sphingomyelinase in Cerebral Ischemia-Induced Ceramide and Cytokine Production, and Neuronal Apoptosis

2000 • 208 citations

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

1996 • 203 citations

Ceramide Induces Apoptosis in Cultured Mesencephalic Neurons

1996 • 191 citations

Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis

1998 • 164 citations

p53-dependent ceramide response to genotoxic stress.

1998 • 159 citations

Ceramide Profiling of Complex Lipid Mixtures by Electrospray Ionization Mass Spectrometry

1997 • 157 citations

Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells.

2001 • 149 citations

Structural determination of glycosphingolipids as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisional-activated dissociation on a triple stage quadrupole instrument

2001 • 146 citations

Death-associated Protein (DAP) Kinase Plays a Central Role in Ceramide-induced Apoptosis in Cultured Hippocampal Neurons

2002 • 142 citations

Population-Based Case-Control Study of Amyotrophic Lateral Sclerosis in Western Washington State. II. Diet

2000 • 140 citations

Ceramide‐induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation

2001 • 129 citations

Plasma Membrane Redox System in the Control of Stress-Induced Apoptosis

2000 • 116 citations

Enzymatic/Nonenzymatic Sources of Oxyradicals and Regulation of Antioxidant Defensesa

1994 • 113 citations

Inhibition of Neutral Sphingomyelinase Activation and Ceramide Formation by Glutathione in Hypoxic PC12 Cell Death

1999 • 113 citations

The Lipid Peroxidation Product 4-Hydroxynonenal Impairs Glutamate and Glucose Transport and Choline Acetyltransferase Activity in NSC-19 Motor Neuron Cells

1999 • 107 citations

HNE-Derived 2-Pentylpyrroles Are Generated during Oxidation of LDL, Are More Prevalent in Blood Plasma from Patients with Renal Disease or Atherosclerosis, and Are Present in Atherosclerotic Plaques

2000 • 101 citations

Ceramide induces apoptosis in PC12 cells

1997 • 101 citations

Production of Ceramides Causes Apoptosis during Early Neural Differentiation in Vitro

2000 • 95 citations

Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells

2000 • 89 citations

Oxidative stress leads to cholesterol accumulation in vascular smooth muscle cells

1999 • 86 citations

Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane

1999 • 85 citations

The prostate apoptosis response‐4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis

2000 • 82 citations

Effects of pyrrolidine dithiocarbamate on endothelial cells: protection against oxidative stress

1999 • 68 citations

Involvement of sphingomyelinases in TNF signaling pathways

1999 • 64 citations

Electrospray/Tandem Mass Spectrometry for Quantitative Analysis of Lipid Remodeling in Essential Fatty Acid Deficient Mice

2000 • 63 citations

Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations

1998 • 57 citations

Changes in Free and Esterified Cholesterol

2000 • 47 citations

The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death.

2000 • 44 citations

Signaling in and regulation of ionizing radiation-induced apoptosis in endothelial cells.

1998 • 42 citations

Effects of supplementing with vitamin E on the uptake of low density lipoprotein and the stimulation of cholesteryl ester formation in macrophages

1994 • 41 citations

Assessment of Various Techniques for the Quantitative Extraction of Lysophospholipids from Myocardial Tissues

1994 • 38 citations

Differential cortico-motoneuron vulnerability after chronic mitochondrial inhibition in vitro and the role of glutamate receptors

2001 • 23 citations

Superoxide Potently Induces Ceramide Formation in Glomerular Endothelial Cells

2001 • 18 citations

Persistence of increased cholesteryl ester in human skin fibroblasts is caused by residual exogenous sphingomyelinase and is reversed by phospholipid liposomes

1992 • 11 citations