Mitochondrial fission and fusion dynamics: the long and short of it

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

2008 • 2,822 citations

The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis

2001 • 1,663 citations

A Photoactivatable GFP for Selective Photolabeling of Proteins and Cells

2002 • 1,569 citations

OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

2006 • 1,530 citations

Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A

2004 • 1,505 citations

The Importance of Dendritic Mitochondria in the Morphogenesis and Plasticity of Spines and Synapses

2004 • 1,400 citations

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

2000 • 1,370 citations

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

2000 • 1,269 citations

The axonal transport of mitochondria

2012 • 1,171 citations

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

2008 • 1,057 citations

Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis

2004 • 995 citations

Dynamics of mitochondria in living cells: Shape changes, dislocations, fusion, and fission of mitochondria

1994 • 870 citations

Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum

2007 • 863 citations

Synaptic Mitochondria Are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions

2005 • 797 citations

Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism

2003 • 788 citations

The Machines that Divide and Fuse Mitochondria

2007 • 743 citations

The axonal transport of mitochondria

2005 • 727 citations

Mitochondrial Morphology and Dynamics in Yeast and Multicellular Eukaryotes

2005 • 723 citations

A Lethal Defect of Mitochondrial and Peroxisomal Fission

2007 • 702 citations

Dynamin and Its Role in Membrane Fission

2000 • 689 citations

Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons

2006 • 640 citations

Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by Mitofusins

2002 • 633 citations

Role of Bax and Bak in mitochondrial morphogenesis

2006 • 608 citations

Developmentally Regulated Mitochondrial Fusion Mediated by a Conserved, Novel, Predicted GTPase

1997 • 590 citations

Mitochondrial Fusion in Yeast Requires the Transmembrane GTPase Fzo1p

1998 • 537 citations

Division versus Fusion: Dnm1p and Fzo1p Antagonistically Regulate Mitochondrial Shape

1999 • 517 citations

Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

2003 • 509 citations

Mitochondrial Fusion Intermediates Revealed in Vitro

2004 • 436 citations

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

2004 • 420 citations

Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA

2001 • 413 citations

Two Mitofusin Proteins, Mammalian Homologues of FZO, with Distinct Functions Are Both Required for Mitochondrial Fusion

2003 • 412 citations

Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria

2001 • 397 citations

Fzo1p Is a Mitochondrial Outer Membrane Protein Essential for the Biogenesis of Functional Mitochondria in Saccharomyces cerevisiae

1998 • 361 citations

The relevance of mitochondrial membrane topology to mitochondrial function

2005 • 270 citations

Release of OPA1 during Apoptosis Participates in the Rapid and Complete Release of Cytochrome c and Subsequent Mitochondrial Fragmentation

2005 • 247 citations

Bcl-x _L induces Drp1-dependent synapse formation in cultured hippocampal neurons

2008 • 211 citations

Separate fusion of outer and inner mitochondrial membranes

2005 • 208 citations

Role for CED-9 and Egl-1 as Regulators of Mitochondrial Fission and Fusion Dynamics

2006 • 186 citations

Morpho-dynamic changes of mitochondria during ageing of human endothelial cells

2005 • 156 citations

Merging mitochondria matters

2002 • 137 citations

Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons

2006 • 132 citations

The Drosophila parkin homologue is required for normal mitochondrial dynamics during spermiogenesis

2006 • 68 citations

Dysregulation of mitochondrial fusion and fission: an emerging concept in neurodegeneration

2006 • 60 citations