A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin

Exercise: a behavioral intervention to enhance brain health and plasticity

2002 • 2,571 citations

Trk Receptors: Roles in Neuronal Signal Transduction

2003 • 2,410 citations

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 • 2,057 citations

Socioeconomic factors and cardiovascular disease: a review of the literature.

1993 • 1,842 citations

Why do we age?

2000 • 1,696 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

The Endocrine Regulation of Aging by Insulin-like Signals

2003 • 1,342 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

Diabetes Mellitus and Risk of Alzheimer Disease and Decline in Cognitive Function

2004 • 1,200 citations

Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity

2001 • 1,085 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice

2002 • 932 citations

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

2003 • 858 citations

Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities

1999 • 825 citations

Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study

1996 • 817 citations

Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

2003 • 782 citations

Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity

2001 • 738 citations

Caloric Intake and Aging

1997 • 736 citations

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

1999 • 733 citations

Sex, stress and the hippocampus: allostasis, allostatic load and the aging process

2002 • 725 citations

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

2003 • 688 citations

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

2000 • 661 citations

Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant

2000 • 606 citations

Structural biology of insulin and IGF1 receptors: implications for drug design

2002 • 577 citations

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

2002 • 573 citations

Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma.

1992 • 521 citations

Region-Specific Neurotrophin Imbalances in Alzheimer Disease

2000 • 499 citations

Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis

2001 • 486 citations

Insulin and the insulin receptor in experimental models of learning and memory

2004 • 478 citations

Reduced BDNF mRNA Expression in the Parkinson's Disease Substantia Nigra

2000 • 474 citations

Regulatory Changes in Neuroendocrine Stress-Integrative Circuitry Produced by a Variable Stress Paradigm

1995 • 454 citations

Serum insulin-like growth factor I regulates brain amyloid-β levels

2002 • 440 citations

Genetics and the Specificity of the Aging Process

2003 • 439 citations

Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior

2002 • 436 citations

Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors

2003 • 435 citations

Serotonergic control of the organization of feeding and satiety

1995 • 419 citations

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

2003 • 417 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments

1997 • 397 citations

Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism

2004 • 363 citations

Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: Evidence for a preconditioning mechanism

1999 • 354 citations

Obesity, Insulin Resistance, and Cardiovascular Disease

2004 • 348 citations

Brain-derived neurotrophic factor in Huntington disease

2000 • 326 citations

Characteristics of BDNF-induced weight loss

1995 • 313 citations

Insulin-like growth factor-I and neurogenesis in the adult mammalian brain

2002 • 307 citations

Selective Serotonin Reuptake Inhibitors and Myocardial Infarction

2001 • 307 citations

Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice.

2000 • 304 citations

Transactivation of the EGF Receptor Mediates IGF-1-stimulated Shc Phosphorylation and ERK1/2 Activation in COS-7 Cells

2000 • 253 citations

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

1992 • 253 citations

Catecholamines, growth hormone, cortisol, insulin, and sex hormones in anaerobic and aerobic exercise

1982 • 250 citations

Novel therapeutic approaches beyond the serotonin receptor

1998 • 242 citations

Insulin resistance in patients with depression and its changes during the clinical course of depression: Minimal model analysis

2000 • 233 citations

BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration

1996 • 231 citations

Insulin-like growth factor-1 and post-ischemic brain injury

2003 • 196 citations

Physical Fitness and Changes in Mortality

2001 • 195 citations

Dopa decarboxylase (Ddc) affects variation in Drosophila longevity

2003 • 193 citations

Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity

2001 • 187 citations

Brain‐derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice

2001 • 183 citations

Reversal of Behavioral and Metabolic Abnormalities, and Insulin Resistance Syndrome, by Dietary Restriction in Mice Deficient in Brain-Derived Neurotrophic Factor

2003 • 179 citations

Intermittent Food Deprivation Improves Cardiovascular and Neuroendocrine Responses to Stress in Rats

2003 • 167 citations

Dopamine and Serotonin Systems in Human and Rodent Brain: Effects of Age and Neurodegenerative Disease

1987 • 167 citations

Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase

2003 • 160 citations

SEROTONERGIC MODULATION OF BEHAVIOUR: A PHYLOGENETIC OVERVIEW

1997 • 156 citations

Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans

2001 • 154 citations

Insulin Receptor Substrate (IRS)-1 and IRS-2 Are Tyrosine-phosphorylated and Associated with Phosphatidylinositol 3-Kinase in Response to Brain-derived Neurotrophic Factor in Cultured Cerebral Cortical Neurons

1997 • 152 citations

Stress Resistance by Caloric Restriction for Longevity

2001 • 131 citations

Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.

1996 • 131 citations

Cortisol, ACTH, and cardiovascular response to a cognitive challenge paradigm in aging and depression

1995 • 130 citations

Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats

1999 • 124 citations

Low Central Nervous System Serotonergic Responsivity Is Associated with the Metabolic Syndrome and Physical Inactivity

2004 • 124 citations

SEROTONERGIC MODULATION OF BEHAVIOUR: A PHYLOGENETIC OVERVIEW

1997 • 121 citations

Brain‐derived neurotrophic factor (BDNF) regulates glucose and energy metabolism in diabetic mice

2002 • 120 citations

Food intake and serum insulin responses to intraventricular infusions of insulin and IGF-I

1991 • 120 citations

Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats

2001 • 117 citations

The glucocorticoid paradox of caloric restriction in slowing brain aging

2002 • 115 citations

Insulin-Like Growth Factors as Mediators of Functional Plasticity in the Adult Brain

1999 • 114 citations

Life Span Extension by Reduction in Growth Hormone-Insulin-Like Growth Factor-1 Axis in a Transgenic Rat Model

2002 • 111 citations

Brain-derived neurotrophic factor, behavior, and new directions for the treatment of mental disorders

2003 • 110 citations

Brain insulin and feeding: a bi-directional communication

2004 • 107 citations

Learning at Different Satiation Levels Reveals Parallel Functions for the cAMP–Protein Kinase A Cascade in Formation of Long-Term Memory

2004 • 105 citations

Quality of life and metabolic status in mildly depressed women with type 2 diabetes treated with paroxetine: A single-blind randomised placebo controlled trial

2003 • 105 citations

Neurotrophic growth factors and neurodegenerative diseases: Therapeutic potential of the neurotrophins and ciliary neurotrophic factor

1994 • 100 citations

Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction

2003 • 99 citations

Paroxetine retards disease onset and progression in Huntingtin mutant mice

2004 • 91 citations

Neurological Changes Induced by Stress in Streptozotocin Diabetic Rats

1999 • 89 citations

Changes in BDNF-immunoreactive structures in the hippocampal formation of the aged macaque monkey

2001 • 80 citations

The Role of Neurotransmitters in Neurite Outgrowth and Synapse Formation

2003 • 77 citations

Assessment of autonomic function in high level athletes by pupillometry

2003 • 73 citations

5-Hydroxytryptamine1A receptor/Giβγ stimulates mitogen-activated protein kinase via NAD(P)H oxidase and reactive oxygen species upstream of Src in Chinese hamster ovary fibroblasts

2000 • 71 citations

A genetic switch for long-term memory

1998 • 71 citations

A Ketogenic Diet Increases Brain Insulin-Like Growth Factor Receptor and Glucose Transporter Gene Expression

2003 • 71 citations

Long-term effects of chronic social stress on serotonergic indices in the prefrontal cortex of adult male cynomolgus macaques

1995 • 68 citations

Activation of Extracellular-Regulated Kinase by 5-Hydroxytryptamine_2AReceptors in PC12 Cells is Protein Kinase C-Independent and Requires Calmodulin and Tyrosine Kinases

2002 • 65 citations

Chronic unpredictable stress causes attenuation of serotonin responses in cornu ammonis 1 pyramidal neurons

2003 • 62 citations

Transgenic overexpression of insulin-like growth factor I prevents streptozotocin-induced cardiac contractile dysfunction and beta-adrenergic response in ventricular myocytes

2004 • 58 citations

Exercise‐induced changes in brain glucose and serotonin revealed by microdialysis in rat hippocampus: effect of glucose supplementation

2001 • 57 citations

Life span: getting the signal from the nervous system

2002 • 52 citations

Dietary Restriction Selectively Decreases Glucocorticoid Receptor Expression in the Hippocampus and Cerebral Cortex of Rats

2000 • 52 citations

Reduced expression of insulin-like growth factor 1 messenger RNA in the hippocampus of aged rats

2000 • 50 citations

Neurochemical changes related to ageing in the rat brain and the effect of dl-α-lipoic acid

2002 • 49 citations

Overexpression of insulin-like growth factor binding protein-1 in transgenic mice

2000 • 45 citations

Insulin-Like Growth Factor-I (IGF-I) Ameliorates and IGF Binding Protein-1 (IGFBP-1) Exacerbates the Effects of Undernutrition on Brain Growth during Early Postnatal Life: Studies in IGF-I and IGFBP-1 Transgenic Mice

1999 • 44 citations

5-H<sub>T2A</sub> Receptor Activation Leads to Increased BDNF mRNA Expression in C6 Glioma Cells

2002 • 44 citations

Bupropion and paroxetine differentially influence cardiovascular and neuroendocrine responses to stress in depressed patients

2002 • 41 citations

Gq-coupled Receptors Transmit the Signal for GLUT4 Translocation via an Insulin-independent Pathway

1996 • 39 citations

Serotonin modulation of cerebral glucose metabolism in normal aging

2003 • 38 citations

Treatment of abdominally obese men with a serotonin reuptake inhibitor: a pilot study

2001 • 35 citations

Activation of 5-HT Receptors That Stimulate the Adenylyl Cyclase Pathway Positively Regulates IGF-I in Cultured Craniofacial Mesenchymal Cells

2001 • 32 citations

IGF-1 activates p21 to inhibit UV-induced cell death

2003 • 29 citations

Knockout Corner: Neurobehavioural consequences of a serotonin 5-HT2C receptor gene mutation

1999 • 27 citations

5-Hydroxytryptamine1A receptor/Giβγ stimulates mitogen-activated protein kinase via NAD(P)H oxidase and reactive oxygen species upstream of Src in Chinese hamster ovary fibroblasts

2000 • 24 citations

Education and the Association Between Vascular Risk Factors and Cognitive Function: A Cross-Sectional Study in Older Koreans With Cognitive Impairment

2003 • 22 citations

Insulin found at last?

1988 • 15 citations

Exercise Training and Dietary Carbohydrate: Effects on Selected Hormones and the Thermic Effect of Feeding

1993 • 12 citations

Fluoxetine induced insulin-like growth factor II (IGF-II) changes in hypothalami of normal, exercised and food restricted rats

1993 • 9 citations

Neurochemical Modulation of the Hippocampus in Learning, Remembering and Forgetting in Primates

1996 • 7 citations