Neurohormetic phytochemicals: low-dose toxins that induce adaptive neuronal stress responses

Exercise: a behavioral intervention to enhance brain health and plasticity

2002 • 2,571 citations

Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase

2004 • 2,531 citations

Neural consequences of enviromental enrichment

2000 • 2,376 citations

Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals

2003 • 2,092 citations

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

2004 • 1,823 citations

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

2001 • 1,482 citations

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

2004 • 1,052 citations

Calcium regulation of neuronal gene expression

2001 • 1,003 citations

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

2003 • 989 citations

BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

2004 • 893 citations

Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action

2004 • 780 citations

Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice

2005 • 663 citations

Defining hormesis

2002 • 644 citations

The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin

2005 • 583 citations

Roles for NF-κB in nerve cell survival, plasticity, and disease

2006 • 540 citations

Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation bytert-Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult

2004 • 528 citations

Resveratrol protects against global cerebral ischemic injury in gerbils

2002 • 515 citations

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

2005 • 513 citations

3-Nitropropionic Acid - Exogenous Animal Neurotoxin and Possible Human Striatal Toxin

1991 • 476 citations

Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders

2003 • 469 citations

Celastrols as Inducers of the Heat Shock Response and Cytoprotection

2004 • 422 citations

Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells

2005 • 421 citations

Dietary pesticides (99.99% all natural).

1990 • 400 citations

A Role for SIR-2.1 Regulation of ER Stress Response Genes in Determining C. elegans Life Span

2005 • 399 citations

Nrf2: A Potential Molecular Target for Cancer Chemoprevention by Natural Compounds

2006 • 355 citations

Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: Evidence for a preconditioning mechanism

1999 • 354 citations

Mechanism of Action of St John???s Wort in Depression

2003 • 350 citations

Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds

2005 • 346 citations

Multifunctional Activities of Green Tea Catechins in Neuroprotection

2005 • 338 citations

Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampus

1990 • 332 citations

Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration

2005 • 316 citations

Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide‐related toxicity in cultured hippocampal neurons

2000 • 302 citations

Stress Proteins and Tolerance to Focal Cerebral Ischemia

1996 • 298 citations

The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology

2004 • 281 citations

Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition

2006 • 280 citations

Neuroprotective effects of green and black teas and their catechin gallate esters against β‐amyloid‐induced toxicity

2005 • 275 citations

Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats

2005 • 264 citations

Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals

2004 • 254 citations

ENERGY INTAKE, MEAL FREQUENCY, AND HEALTH: A Neurobiological Perspective

2005 • 251 citations

Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress

2005 • 235 citations

Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits

2005 • 231 citations

Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin

2004 • 222 citations

Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage

2004 • 215 citations

Activation of Mitochondrial ATP-Dependent Potassium Channels Protects Neurons against Ischemia-Induced Death by a Mechanism Involving Suppression of Bax Translocation and Cytochrome c Release

2002 • 214 citations

CREB-Mediated Bcl-2 Protein Expression after Ischemic Preconditioning

2005 • 209 citations

Enhancement by an Ampakine of Memory Encoding in Humans

1997 • 205 citations

Cancer Biology and Hormesis: Human Tumor Cell Lines Commonly Display Hormetic (Biphasic) Dose Responses

2005 • 195 citations

Uncoupling Protein 2 Prevents Neuronal Death Including that Occurring during Seizures: A Mechanism for Preconditioning

2003 • 188 citations

Sulforaphane Induces Thioredoxin through the Antioxidant-Responsive Element and Attenuates Retinal Light Damage in Mice

2005 • 187 citations

Mitochondrial UCP4 Mediates an Adaptive Shift in Energy Metabolism and Increases the Resistance of Neurons to Metabolic and Oxidative Stress

2006 • 176 citations

Neuroprotection by Hypoxic Preconditioning Involves Oxidative Stress-Mediated Expression of Hypoxia-Inducible Factor and Erythropoietin

2005 • 176 citations

The excitoprotective effect of N‐methyl‐<scp>d</scp>‐aspartate receptors is mediated by a brain‐derived neurotrophic factor autocrine loop in cultured hippocampal neurons

2005 • 152 citations

The activation of glutamate receptors by kainic acid and domoic acid

1998 • 144 citations

Calcium/calmodulin‐dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons

2001 • 140 citations

Heme oxygenase-2 acts to prevent neuronal death in brain cultures and following transient cerebral ischemia

2000 • 140 citations

Mutually Protective Actions of Kainic Acid Epileptic Preconditioning and Sublethal Global Ischemia on Hippocampal Neuronal Death: Involvement of Adenosine A₁ Receptors and K_ATP Channels

1999 • 134 citations

Phosphorylation of Bcl-2 in G2/M Phase-arrested Cells following Photodynamic Therapy with Hypericin Involves a CDK1-mediated Signal and Delays the Onset of Apoptosis

2002 • 117 citations

Ischemic Tolerance

2002 • 115 citations

Antioxidant nutrients and hypoxia/ischemia brain injury in rodents

2003 • 109 citations

Intracellular signaling network as a prime chemopreventive target of (–)‐epigallocatechin gallate

2006 • 95 citations

S-allyl-l-cysteine selectively protects cultured rat hippocampal neurons from amyloid β-protein- and tunicamycin-induced neuronal death

2003 • 91 citations

Grape Extract, Resveratrol, and Its Analogs: A Review

2001 • 89 citations

Effect of ischemic preconditioning on the expression of putative neuroprotective genes in the rat brain

2002 • 86 citations

Opening of Mitochondrial ATP-Sensitive Potassium Channels Is a Trigger of 3-Nitropropionic Acid–Induced Tolerance to Transient Focal Cerebral Ischemia in Rats

2003 • 86 citations

Nitric oxide and cerebral ischemic preconditioning

2004 • 84 citations

N‐Methyl‐d‐aspartate and TrkB Receptor Activation in Cerebellar Granule Cells

2003 • 76 citations

Potentiation of a Survival Signal in the Ischemic Heart by Resveratrol through p38 Mitogen-Activated Protein Kinase/Mitogen- and Stress-Activated Protein Kinase 1/cAMP Response Element-Binding Protein Signaling

2006 • 74 citations

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury

2005 • 72 citations

Allyl-Containing Sulfides in Garlic Increase Uncoupling Protein Content in Brown Adipose Tissue, and Noradrenaline and Adrenaline Secretion in Rats

1999 • 57 citations

Garlic Organosulfur Compounds Upregulate the Expression of the π Class of Glutathione S-Transferase in Rat Primary Hepatocytes

2005 • 51 citations

Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress

2005 • 44 citations

Age-related changes in tolerance to the marine algal excitotoxin domoic acid

2002 • 41 citations

Interleukin-6 Involvement in Antidepressant Action of Hypericum Perforatum

2001 • 40 citations

The critical threshold of 3-nitropropionic acid-induced ischemic tolerance in the rat

2005 • 19 citations

Protective effects of Korean herbal remedy against oxidative stress in cardiomyocytes

2006 • 12 citations

Effects of Uwhangchungsimwon on Cell Viability, Proliferation, and Gene Expression of Human Neuronal Cell line IMR32

2001 • 7 citations

Drugs and the atrioventricular conducting system.

1977 • 1 citations

Deleted Work

1955 • 0 citations