Mitochondria in the aetiology and pathogenesis of Parkinson's disease

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Epidemiology of Parkinson's disease

2006 • 3,818 citations

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

2000 • 3,559 citations

Mitochondrial Membrane Permeabilization in Cell Death

2007 • 3,375 citations

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

2004 • 3,278 citations

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

2003 • 2,691 citations

Oxidative stress in Parkinson's disease

2003 • 2,001 citations

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

2000 • 1,975 citations

The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis

1999 • 1,872 citations

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

1989 • 1,717 citations

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

2000 • 1,628 citations

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

2006 • 1,489 citations

Association between Early-Onset Parkinson's Disease and Mutations in theParkinGene

2000 • 1,398 citations

The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service

2002 • 1,178 citations

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

2005 • 1,172 citations

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

2003 • 1,156 citations

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

2004 • 1,091 citations

Abnormalities of the electron transport chain in idiopathic parkinson's disease

1989 • 1,067 citations

An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

2001 • 1,048 citations

Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

2000 • 975 citations

Effects of Coenzyme Q10 in Early Parkinson Disease

2002 • 965 citations

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

2004 • 959 citations

Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

2003 • 884 citations

‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease

2007 • 864 citations

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

2006 • 861 citations

DJ‐1 has a role in antioxidative stress to prevent cell death

2004 • 828 citations

Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice

2002 • 760 citations

A common LRRK2 mutation in idiopathic Parkinson's disease

2005 • 758 citations

S -Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function

2004 • 750 citations

DJ-1, a Novel Oncogene Which Transforms Mouse NIH3T3 Cells in Cooperation withras

1997 • 736 citations

Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease

1989 • 735 citations

Parkinson's Disease Brain Mitochondrial Complex I Has Oxidatively Damaged Subunits and Is Functionally Impaired and Misassembled

2006 • 703 citations

α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress

2000 • 694 citations

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress

2005 • 676 citations

Anatomic and Disease Specificity of NADH CoQ₁ Reductase (Complex I) Deficiency in Parkinson's Disease

1990 • 676 citations

Parkinson's Disease α-Synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death

2006 • 648 citations

Origin and functional consequences of the complex I defect in Parkinson's disease

1996 • 629 citations

α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

2005 • 600 citations

AnIn VitroModel of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

2002 • 575 citations

DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation

2004 • 572 citations

Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP

2002 • 569 citations

Altered Proteasomal Function in Sporadic Parkinson's Disease

2002 • 565 citations

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

2007 • 561 citations

Mitochondrial disease

2006 • 557 citations

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

2005 • 554 citations

Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease

2003 • 543 citations

Identification of a Novel LRRK2 Mutation Linked to Autosomal Dominant Parkinsonism: Evidence of a Common Founder across European Populations

2005 • 535 citations

Parkinsonism, premature menopause, and mitochondrial DNA polymerase γ mutations: clinical and molecular genetic study

2004 • 535 citations

Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

2004 • 531 citations

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

2005 • 520 citations

Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

2005 • 518 citations

PINK1 mutations are associated with sporadic early‐onset parkinsonism

2004 • 480 citations

Lewy bodies and parkinsonism in families with parkin mutations

2001 • 479 citations

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1

2007 • 467 citations

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

2005 • 464 citations

The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

2004 • 454 citations

Mitochondrial DNA Variants Observed in Alzheimer Disease and Parkinson Disease Patients

1993 • 449 citations

Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease

2005 • 448 citations

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

2005 • 442 citations

Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease

1995 • 430 citations

A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease

2006 • 426 citations

Inhibition of neuronal nitric oxide synthase prevents MPTP–induced parkinsonism in baboons

1996 • 422 citations

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

2005 • 418 citations

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

2005 • 412 citations

Genetic and environmental factors in the cause of Parkinson's disease

2003 • 383 citations

Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice

2004 • 383 citations

Creatine and Cyclocreatine Attenuate MPTP Neurotoxicity

1999 • 372 citations

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway

2001 • 365 citations

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

2005 • 363 citations

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

2003 • 358 citations

Platelet mitochondria function in Parkinson's disease

1992 • 350 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

1990 • 345 citations

BRAIN, SKELETAL MUSCLE AND PLATELET HOMOGENATE MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE

1992 • 341 citations

Early-onset parkinsonism associated with PINK1 mutations

2005 • 335 citations

PINK1 protein in normal human brain and Parkinson's disease

2006 • 328 citations

Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system

2006 • 325 citations

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

2003 • 323 citations

Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease

1998 • 313 citations

DJ-1 Positively Regulates the Androgen Receptor by Impairing the Binding of PIASxα to the Receptor

2001 • 312 citations

Mitochondrial involvement in Parkinson’s disease, Huntington’s disease, hereditary spastic paraplegia and Friedreich’s ataxia

1999 • 309 citations

Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

2005 • 304 citations

How much phenotypic variation can be attributed to parkin genotype?

2003 • 291 citations

Novel pharmacological targets for the treatment of Parkinson's disease

2006 • 290 citations

Immunohistochemical and subcellular localization of parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients

1999 • 274 citations

Parkin enhances mitochondrial biogenesis in proliferating cells

2006 • 261 citations

Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease

2003 • 259 citations

The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis

2005 • 246 citations

Lewy body Parkinson's disease in a large pedigree with 77Parkin mutation carriers

2005 • 242 citations

Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe

2003 • 242 citations

Complex I, Iron, and ferritin in Parkinson's disease substantia nigra

1994 • 239 citations

Early‐onset familial parkinsonism due to POLG mutations

2006 • 232 citations

Novel PINK1 mutations in early-onset parkinsonism

2005 • 226 citations

Biochemical and pathological characterization of Lrrk2

2006 • 223 citations

Identification of Mitochondrial DNA Polymorphisms That Alter Mitochondrial Matrix pH and Intracellular Calcium Dynamics

2006 • 219 citations

Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease

2006 • 215 citations

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations

2003 • 212 citations

An autopsy case of autosomal-recessive juvenile parkinsonism with a homozygous exon 4 deletion in theparkin gene

2000 • 209 citations

A randomized clinical trial of coenzyme Q ₁₀ and GPI-1485 in early Parkinson disease

2007 • 208 citations

Clinical and subclinical dopaminergic dysfunction in PARK6‐linked parkinsonism: An ¹⁸F‐dopa PET study

2002 • 201 citations

Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease

1994 • 201 citations

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

2005 • 201 citations

Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

2000 • 198 citations

Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease

2003 • 196 citations

Randomized, Double-blind, Placebo-Controlled Trial on Symptomatic Effects of Coenzyme Q10 in Parkinson Disease

2007 • 195 citations

Creatine supplementation in Parkinson disease: A placebo-controlled randomized pilot trial

2006 • 194 citations

Analysis of the PINK1 Gene in a Large Cohort of Cases With Parkinson Disease

2004 • 193 citations

Clinical features ofLRRK2-associated Parkinson's disease in central Norway

2005 • 186 citations

Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD

2005 • 179 citations

TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial

2006 • 176 citations

A novel mitochondrial 12SrRNA point mutation in parkinsonism, deafness, and neuropathy

2000 • 173 citations

A heterozygous effect for PINK1 mutations in Parkinson's disease?

2006 • 163 citations

Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease

2005 • 162 citations

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

2006 • 161 citations

Inhibitory effects of pesticides on proteasome activity: Implication in Parkinson's disease

2006 • 153 citations

LRRK2 mutations in Parkinson disease

2005 • 152 citations

Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline

2006 • 149 citations

A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations

2005 • 149 citations

Point mutations of mitochondrial genome in Parkinson's disease

1995 • 147 citations

Treatment Options in the Modern Management of Parkinson Disease

2007 • 139 citations

Clinical Spectrum of Homozygous and Heterozygous PINK1 Mutations in a Large German Family With Parkinson Disease

2006 • 136 citations

Parkin is associated with cellular vesicles

2001 • 132 citations

Homozygous PINK1 C‐terminus mutation causing early‐onset parkinsonism

2004 • 129 citations

Pesticide Exposure Exacerbates α-Synucleinopathy in an A53T Transgenic Mouse Model

2007 • 128 citations

Distinct clustering of point mutations in mitochondrial DNA among patients with mitochondrial encephalomyopathies and with Parkinson's disease

1991 • 123 citations

An out-of-frame cytochromeb gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production

2000 • 118 citations

Clinical and Genetic Heterogeneity in Progressive External Ophthalmoplegia Due to Mutations in Polymerase γ

2003 • 115 citations

Parkin Phosphorylation and Modulation of Its E3 Ubiquitin Ligase Activity

2004 • 114 citations

Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins

1998 • 112 citations

mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish

2003 • 111 citations

Mitochondrial ND5 mutations in idiopathic Parkinson’s disease

2004 • 111 citations

Mitochondrial DNA analysis in Parkinson's disease

1990 • 109 citations

PINK1 mutations in sporadic early‐onset Parkinson's disease

2006 • 99 citations

The dardarin G2019S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases

2005 • 97 citations

Myopathy in vitamin E deficient rats: muscle fibre necrosis associated with disturbances of mitochondrial function.

1993 • 95 citations

A Novel Polymerase γ Mutation in a Family With Ophthalmoplegia, Neuropathy, and Parkinsonism

2004 • 94 citations

Parkin expression in the adult mouse brain

2000 • 92 citations

Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases

1986 • 92 citations

Oxidative stress in Parkinson's disease

1995 • 87 citations

Mutation of the Linker Region of the Polymerase γ-1 (POLG1Gene Associated With Progressive External Ophthalmoplegia and Parkinsonism

2007 • 82 citations

Generalized mitochondrial dysfunction in Parkinson's disease detected by magnetic resonance spectroscopy of muscle

1995 • 79 citations

Sequence Analysis of the Entire Mitochondrial Genome in Parkinson's Disease

2002 • 78 citations

Smoking and mitochondrial function: a model for environmental toxins

1993 • 74 citations

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

2003 • 66 citations

A 31P magnetic resonance spectroscopy study of mitochondrial function in skeletal muscle of patients with Parkinson's disease

1994 • 62 citations

Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: Role of Na+/K+ ATPase

2006 • 51 citations

Novel mitochondrial DNA mutations in Parkinson's disease

2002 • 46 citations

The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism

2004 • 43 citations

Analysis of the trinucleotide CAG repeat from the DNA polymerase γ gene (POLG) in patients with Parkinson's disease

2004 • 42 citations

Genetic association study of PINK1 coding polymorphisms in Parkinson's disease

2004 • 32 citations

Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis

2007 • 31 citations

G209A mutant alpha synuclein expression specifically enhances dopamine induced oxidative damage

2004 • 30 citations

The Importance of LRRK2 Mutations in Parkinson Disease

2006 • 30 citations

Mitochondrial translation initiation factor 3 gene polymorphism associated with Parkinson's disease

2007 • 28 citations

Parkinson disease: analysis of mitochondrial DNA in monozygotic twins.

2000 • 22 citations

Absence of the Mitochondrial A7237T Mutation in Parkinson′s Disease

1995 • 20 citations

Parkinson disease: analysis of mitochondrial DNA in monozygotic twins

2000 • 17 citations