PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

2004 • 3,278 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

1990 • 2,147 citations

Parkinson's Disease

1998 • 1,953 citations

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

1989 • 1,717 citations

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

1999 • 1,163 citations

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

2004 • 1,091 citations

Modulation of neurodegeneration by molecular chaperones

2004 • 998 citations

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

2006 • 765 citations

Genetics of Parkinson disease: paradigm shifts and future prospects

2006 • 686 citations

Animal models of Parkinson's disease

2002 • 580 citations

AnIn VitroModel of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

2002 • 575 citations

Oxidative Modifications and Down-regulation of Ubiquitin Carboxyl-terminal Hydrolase L1 Associated with Idiopathic Parkinson's and Alzheimer's Diseases

2004 • 548 citations

Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases

2006 • 457 citations

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

2005 • 442 citations

Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways

2005 • 413 citations

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

2005 • 363 citations

The hsp90-related Protein TRAP1 Is a Mitochondrial Protein with Distinct Functional Properties

2000 • 358 citations

Improved methods to isolate and subfractionate rat liver mitochondria. Lipid composition of the inner and outer membrane

1990 • 348 citations

Early-onset parkinsonism associated with PINK1 mutations

2005 • 335 citations

PINK1 protein in normal human brain and Parkinson's disease

2006 • 328 citations

Wild-type PINK1 Prevents Basal and Induced Neuronal Apoptosis, a Protective Effect Abrogated by Parkinson Disease-related Mutations

2005 • 324 citations

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism

2001 • 311 citations

Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function

2004 • 269 citations

Identification of a Protein with Homology to hsp90 That Binds the Type 1 Tumor Necrosis Factor Receptor

1995 • 265 citations

Novel PINK1 mutations in early-onset parkinsonism

2005 • 226 citations

Antioxidants protect PINK1 -dependent dopaminergic neurons in Drosophila

2006 • 200 citations

Hrs Interacts with Sorting Nexin 1 and Regulates Degradation of Epidermal Growth Factor Receptor

2001 • 190 citations

A New Member of the hsp90 Family of Molecular Chaperones Interacts with the Retinoblastoma Protein during Mitosis and after Heat Shock

1996 • 183 citations

Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y

2005 • 159 citations

C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1

2006 • 141 citations

Involvement of Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) in Apoptosis Induced by β-Hydroxyisovalerylshikonin

2004 • 139 citations

Clinical Spectrum of Homozygous and Heterozygous PINK1 Mutations in a Large German Family With Parkinson Disease

2006 • 136 citations

An indirect immunofluorescence procedure for staining the same cryosection with two mouse monoclonal primary antibodies.

1993 • 118 citations

SNIP, a Novel SNAP-25-interacting Protein Implicated in Regulated Exocytosis

2000 • 99 citations

Huntingtin-associated Protein 1 Interacts with Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate and Functions in Endosomal Trafficking

2002 • 94 citations

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

2003 • 66 citations

PINK1 homozygous W437X mutation in a patient with apparent dominant transmission of parkinsonism

2006 • 51 citations

GRIF1 binds Hrs and is a new regulator of endosomal trafficking

2006 • 39 citations

Homozygous and heterozygous PINK1 mutations: Considerations for diagnosis and care of Parkinson's disease patients

2006 • 34 citations