4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

Localization of neuronal and glial glutamate transporters

1994 • 1,668 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1995 • 1,430 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

1992 • 1,170 citations

The release and uptake of excitatory amino acids

1990 • 1,090 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

1996 • 956 citations

Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations

1995 • 884 citations

Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons

1996 • 833 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

1997 • 779 citations

Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate

1995 • 779 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

1995 • 641 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca²⁺ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

1995 • 616 citations

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

1995 • 580 citations

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

1995 • 559 citations

Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

1988 • 557 citations

Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction.

1993 • 512 citations

ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

1994 • 498 citations

Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

1992 • 481 citations

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.

1990 • 478 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes

1994 • 462 citations

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

1990 • 456 citations

Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury

1994 • 445 citations

Free radicals in brain metabolism and pathology

1993 • 443 citations

Transport and Metabolism of Glutamate and Gaba in Neurons and Glial Cells

1981 • 437 citations

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

1994 • 406 citations

Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

1997 • 403 citations

Chapter 6 Glutamate receptors and the induction of excitotoxic neuronal death

1994 • 387 citations

Are reactive oxygen species involved in Alzheimer's disease?

1995 • 358 citations

Synaptic and neuritic alterations during the progression of Alzheimer's disease

1994 • 355 citations

Chapter 10 Calcium, Free Radicals, and Excitotoxic Neuronal Death in Primary Cell Culture

1995 • 338 citations

Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate.

1994 • 337 citations

Alterations in L-Glutamate Binding in Alzheimer's and Huntington's Diseases

1985 • 334 citations

Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus

1994 • 325 citations

Acute dendrotoxic changes in the hippocampus of kainate treated rats

1979 • 306 citations

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1990 • 283 citations

Growth Factors Prevent Mitochondrial Dysfunction, Loss of Calcium Homeostasis, and Cell Injury, but Not ATP Depletion in Hippocampal Neurons Deprived of Glucose

1993 • 265 citations

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

1992 • 253 citations

Michael Addition-Type 4-Hydroxy-2-nonenal Adducts in Modified Low-Density Lipoproteins: Markers for Atherosclerosis

1994 • 248 citations

Modification of human low-density lipoprotein by the lipid peroxidation product 4-hydroxynonenal

1986 • 241 citations

A new family of neurotransmitter transporters: the high‐affinity glutamate transporters

1993 • 228 citations

Temporal lobe epilepsy caused by domoic acid intoxication: Evidence for glutamate receptor–mediated excitotoxicity in humans

1995 • 224 citations

Free radicals in CNS injury.

1993 • 221 citations

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1996 • 212 citations

The Intracellular Component of Cellular 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction Is Specifically Inhibited by β‐Amyloid Peptides

1995 • 204 citations

Basic FGF, NGF, and IGFs Protect Hippocampal and Cortical Neurons against Iron-Induced Degeneration

1993 • 199 citations

The elusive transporters with a high affinity for glutamate

1993 • 195 citations

Regulation of synaptic transmission in the central nervous system: Long-term potentiation

1989 • 186 citations

O2 free radicals: cause of ischemia-reperfusion injury to cardiac Na+-K+-ATPase

1987 • 183 citations

Ion transport ATPases as targets for free radical damage

1993 • 178 citations

4-Hydroxynonenal inhibits Na+-K+-ATPase

1996 • 164 citations

Basic mechanisms of traumatic brain damage

1993 • 158 citations

Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein(a).

1993 • 150 citations

Neurotransmitter transporters: three distinct gene families

1993 • 141 citations

Peroxynitrite Formed by Simultaneous Nitric Oxide and Superoxide Generation Causes Cyclosporin‐A‐Sensitive Mitochondrial Calcium Efflux and Depolarisation

1995 • 140 citations

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF

1992 • 137 citations

4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, Impairs Signal Transduction Associated with Muscarinic Acetylcholine and Metabotropic Glutamate Receptors: Possible Action on Gα_q/11

1997 • 134 citations

Amyloid β-peptide and oxidative cellular injury in Alzheimer’s disease

1996 • 132 citations

E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures.

1996 • 132 citations

Glutamate transporters from brain

1993 • 125 citations

Glutamate and other CSF amino acids in Alzheimer's disease

1992 • 121 citations

Inhibitory Effects of Nitric Oxide on the Uptake of [³H]Dopamine and [³H]Glutamate by Striatal Synaptosomes

1994 • 117 citations

Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines. Do aldehydic by-products of lipid peroxidation contribute to oxidative stress?

1990 • 116 citations

β-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimerʼs disease

1995 • 114 citations

Changes of Respiratory Chain Activity in Mitochondrial and Synaptosomal Fractions Isolated from the Gerbil Brain After Graded Ischaemia

1995 • 110 citations

Nitric oxide inhibits ³H‐glutamate transport in synaptosomes

1994 • 105 citations

Cytotoxicities of a linoleic acid hydroperoxide and its related aliphatic aldehydes toward cultured human umbilical vein endothelial cells

1988 • 100 citations

THE USE OF TETRAZOLIUM SALTS TO DETERMINE SITES OF DAMAGE TO THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN IN INTACT CELLS FOLLOWING in vitro: PHOTODYNAMIC THERAPY WITH PHOTOFRIN II

1994 • 97 citations

Development of kainic acid and N-methyl-d-aspartic acid toxicity in organotypic hippocampal cultures

1995 • 92 citations

β-Amyloid toxicity in organotypic cultures : protection by EUK-8, a synthetic catalytic free radical scavenger

1996 • 85 citations

In vitro polymerization of oxidized tau into filaments

1993 • 84 citations

What excitotoxin kills striatal neurons in Huntington's disease? Clues from neurochemical studies

1990 • 76 citations

4-Hydroxy-2,3-trans-nonenal stimulates microsomal lipid peroxidation by reducing the glutathione-dependent protection

1987 • 59 citations

Synaptosomal glutamate transport in thioacetamide-induced hepatic encephalopathy in the rat

1995 • 52 citations

Inhibition of calcium sequestration activity of liver microsomes by 4-hydroxyalkenals originating from the peroxidation of liver microsomal lipids

1984 • 48 citations

THE USE OF TETRAZOLIUM SALTS TO DETERMINE SITES OF DAMAGE TO THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN IN INTACT CELLS FOLLOWING in vitro PHOTODYNAMIC THERAPY WITH PHOTOFRIN II

1994 • 48 citations

Structural substrates of epilepsy.

1986 • 45 citations

Glutamatergic drugs in Parkinson's disease

1994 • 44 citations

The release and uptake of excitatory amino acids in rat brain: Effect of aging and oxidative stress

1994 • 40 citations

Membrane lipid peroxidation induces changes in γ-[3H]aminobutyric acid transport and calcium uptake by synaptosomes

1993 • 38 citations

4-Hydroxy-2-nonenal-Trapping ELISA: Direct Evidence for the Release of a Cytotoxic Aldehyde from Oxidized Low Density Lipoproteins

1995 • 38 citations

Cytotoxic and genotoxic effects of five in primary cultures of rat and human hepatocytes

1994 • 35 citations

Inhibition of pro-oxidant-induced mitochondrial pyridine nucleotide hydrolysis and calcium release by 4-hydroxynonenal

1990 • 24 citations

The action of 4-hydroxynonenal on the plasma membrane enzymes from rat hepatocytes.

1989 • 18 citations

Changes in non-synaptosomal and synaptosomal mitochondrial membrane-linked enzymatic activities after transient cerebral ischemia

1994 • 17 citations

Synaptosomal glutamate transport in thioacetamide induced hepatic encephalopathy in the rat

1995 • 17 citations

The role of cytosolic free calcium in the regulation of pyruvate dehydrogenase in synaptosomes

1994 • 16 citations

Synaptosomal glutamate uptake in a model of experimental cerebral ischemia

1995 • 10 citations