The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases

Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress

2000 • 3,760 citations

NAD(P)H Oxidase

2000 • 2,902 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly.

2002 • 1,781 citations

Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis

2002 • 1,460 citations

Cell transformation by the superoxide-generating oxidase Mox1

1999 • 1,457 citations

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

2003 • 1,435 citations

The evolution of free radicals and oxidative stress

2000 • 1,384 citations

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

2003 • 1,341 citations

Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus

2001 • 1,192 citations

Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species and Their Role in Vascular Physiology and Pathophysiology

2000 • 959 citations

Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis

2002 • 838 citations

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

1997 • 831 citations

Homologs of gp91 phox : cloning and tissue expression of Nox3, Nox4, and Nox5

2001 • 794 citations

Angiotensin II Stimulation of NAD(P)H Oxidase Activity

2002 • 719 citations

Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis

1999 • 689 citations

Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling

2002 • 679 citations

Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol.

1994 • 647 citations

Novel Competitive Inhibitor of NAD(P)H Oxidase Assembly Attenuates Vascular O ₂ ⁻ and Systolic Blood Pressure in Mice

2001 • 598 citations

A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes

2001 • 598 citations

A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall

2000 • 596 citations

Cellular Antioxidant Effects of Atorvastatin In Vitro and In Vivo

2002 • 590 citations

Expression of a Functionally Active gp91phox-Containing Neutrophil-Type NAD(P)H Oxidase in Smooth Muscle Cells From Human Resistance Arteries

2002 • 589 citations

Role of p47 ^phox in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II

2002 • 566 citations

Vascular Superoxide Production by NAD(P)H Oxidase

2000 • 565 citations

Minireview: Overview of the Renin-Angiotensin System—An Endocrine and Paracrine System

2003 • 558 citations

p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats

1997 • 555 citations

Activation of NADPH Oxidase During Progression of Cardiac Hypertrophy to Failure

2002 • 507 citations

p47phox is required for atherosclerotic lesion progression in ApoE–/– mice

2001 • 478 citations

Two Novel Proteins Activate Superoxide Generation by the NADPH Oxidase NOX1

2003 • 477 citations

Novel Role of gp91 ^phox -Containing NAD(P)H Oxidase in Vascular Endothelial Growth Factor–Induced Signaling and Angiogenesis

2002 • 464 citations

Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II

1997 • 463 citations

Role for Hydrogen Peroxide in Flow-Induced Dilation of Human Coronary Arterioles

2003 • 445 citations

Thrombin Activates the Hypoxia-Inducible Factor-1 Signaling Pathway in Vascular Smooth Muscle Cells

2001 • 415 citations

Mechanical Stretch Enhances mRNA Expression and Proenzyme Release of Matrix Metalloproteinase-2 (MMP-2) via NAD(P)H Oxidase–Derived Reactive Oxygen Species

2003 • 414 citations

Nitric Oxide Is a Physiological Substrate for Mammalian Peroxidases

2000 • 403 citations

Molecular Basis of Phosphorylation-Induced Activation of the NADPH Oxidase

2003 • 393 citations

Angiotensin II Induces Monocyte Chemoattractant Protein-1 Gene Expression in Rat Vascular Smooth Muscle Cells

1998 • 388 citations

Induction of Hypoxia-inducible Factor-1α by Transcriptional and Translational Mechanisms

2002 • 380 citations

Angiotensin II Induces Vascular Cell Adhesion Molecule-1 Expression In Rat Vasculature

1999 • 376 citations

Vascular NADH/NADPH Oxidase Is Involved in Enhanced Superoxide Production in Spontaneously Hypertensive Rats

2000 • 371 citations

Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases

2003 • 366 citations

Endothelial Dysfunction in Chronic Myocardial Infarction Despite Increased Vascular Endothelial Nitric Oxide Synthase and Soluble Guanylate Cyclase Expression

1999 • 361 citations

NADH/NADPH Oxidase and Enhanced Superoxide Production in the Mineralocorticoid Hypertensive Rat

2001 • 343 citations

Role of NADPH Oxidase in the Vascular Hypertrophic and Oxidative Stress Response to Angiotensin II in Mice

2001 • 336 citations

Mechanism of Endothelial Cell NADPH Oxidase Activation by Angiotensin II

2003 • 304 citations

Activation of NADPH Oxidase in Alzheimer's Disease Brains

2000 • 286 citations

Epidermal Growth Factor Receptor Transactivation by Angiotensin II Requires Reactive Oxygen Species in Vascular Smooth Muscle Cells

2001 • 285 citations

Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases

2002 • 281 citations

Proteins Homologous to p47 and p67 Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells

2003 • 274 citations

Role of NAD(P)H Oxidase in Angiotensin II–Induced JAK/STAT Signaling and Cytokine Induction

2000 • 273 citations

Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo

2001 • 266 citations

c-Src Induces Phosphorylation and Translocation of p47phox

2003 • 262 citations

A New Superoxide-generating Oxidase in Murine Osteoclasts

2001 • 218 citations

Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells

1998 • 211 citations

Ang II–Stimulated Superoxide Production Is Mediated via Phospholipase D in Human Vascular Smooth Muscle Cells

1999 • 202 citations

Inhibition of NADPH Oxidase Activation by 4-(2-Aminoethyl)-benzenesulfonyl Fluoride and Related Compounds

1997 • 196 citations

Kinetics of Cytochrome C2+ Oxidation by Peroxynitrite: Implications for Superoxide Measurements in Nitric Oxide-Producing Biological-Systems

1995 • 188 citations

PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox.

1996 • 188 citations

Akt-Dependent Phosphorylation of Serine 1179 and Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase 1/2 Cooperatively Mediate Activation of the Endothelial Nitric-Oxide Synthase by Hydrogen Peroxide

2003 • 188 citations

NAD(P)H Oxidase-derived Hydrogen Peroxide Mediates Endothelial Nitric Oxide Production in Response to Angiotensin II

2002 • 184 citations

Impaired Superoxide Production Due to a Deficiency in Phagocyte NADPH Oxidase Fails to Inhibit Atherosclerosis in Mice

2000 • 175 citations

Inhibition of Growth Factor-induced Protein Synthesis by a Selective MEK Inhibitor in Aortic Smooth Muscle Cells

1996 • 170 citations

Withdrawal of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Elicits Oxidative Stress and Induces Endothelial Dysfunction in Mice

2002 • 165 citations

The respiratory burst oxidase

1995 • 161 citations

Vascular Effects Following Homozygous Disruption of p47 ^phox

2000 • 158 citations

Vascular NADH Oxidase Is Involved in Impaired Endothelium-Dependent Vasodilation in OLETF Rats, a Model of Type 2 Diabetes

2002 • 157 citations

Novel NAD(P)H Oxidase Inhibitor Suppresses Angioplasty-Induced Superoxide and Neointimal Hyperplasia of Rat Carotid Artery

2003 • 142 citations

Genetic Demonstration of p47phox-Dependent Superoxide Anion Production in Murine Vascular Smooth Muscle Cells

2001 • 128 citations

Perivascular Superoxide Anion Contributes to Impairment of Endothelium-Dependent Relaxation

2002 • 111 citations

S17834, a New Inhibitor of Cell Adhesion and Atherosclerosis That Targets NADPH Oxidase

2001 • 110 citations

Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism

1992 • 104 citations

Evidence for a Causal Role of the Renin-Angiotensin System in Nitrate Tolerance

1999 • 103 citations

The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression

2002 • 103 citations

Angiotensin II Activates Endothelial Constitutive Nitric Oxide Synthase via AT1 Receptors.

1996 • 80 citations

Apocynin increases glutathione synthesis and activates AP‐1 in alveolar epithelial cells

1999 • 79 citations

Anti-Microbial Activity and Cell Binding are Controled by Sequence Determinants in the Anti-Microbial Peptide PR-39

2001 • 58 citations

PI3‐kinase p85α Is a Target Molecule of Proline‐rich Antimicrobial Peptide to Suppress Proliferation of ras‐Transformed Cells

2001 • 45 citations

PR-39, a proline/arginine-rich antimicrobial peptide, exerts cardioprotective effects in myocardial ischemia–reperfusion

2001 • 44 citations

Rac-Dependent Monocyte Chemoattractant Protein-1 Production Is Induced by Nutrient Deprivation

2002 • 34 citations

AT1 receptor inhibition blunts angiotensin II-stimulated nitric oxide release in renal arteries.

1999 • 31 citations

Nitric oxide and peroxynitrite in lipid peroxidation.

1998 • 20 citations

Activation of NADPH Oxidase

1991 • 7 citations