Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus

Basic local alignment search tool

1990 • 87,358 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Biochemistry and molecular cell biology of diabetic complications

2001 • 8,707 citations

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

2000 • 8,612 citations

Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels

1998 • 5,229 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

NAD(P)H Oxidase

2000 • 2,902 citations

Prognostic Impact of Coronary Vasodilator Dysfunction on Adverse Long-Term Outcome of Coronary Heart Disease

2000 • 2,616 citations

Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction

2000 • 2,076 citations

Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients

2000 • 1,945 citations

Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease

2001 • 1,944 citations

Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors

1998 • 1,860 citations

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

2000 • 1,537 citations

Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors

1998 • 1,475 citations

Cardiovascular Events and Their Reduction With Pravastatin in Diabetic and Glucose-Intolerant Myocardial Infarction Survivors With Average Cholesterol Levels

1998 • 1,000 citations

Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus

2002 • 970 citations

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

1996 • 884 citations

Novel gp91 ^phox Homologues in Vascular Smooth Muscle Cells

2001 • 841 citations

Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

1986 • 839 citations

Acute Hyperglycemia Attenuates Endothelium-Dependent Vasodilation in Humans In Vivo

1998 • 790 citations

High Glucose Increases Nitric Oxide Synthase Expression and Superoxide Anion Generation in Human Aortic Endothelial Cells

1997 • 765 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

Endothelial Regulation of Vasomotion in ApoE-Deficient Mice

2001 • 719 citations

Superoxide Generation from Endothelial Nitric-oxide Synthase

1998 • 701 citations

Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus

2002 • 674 citations

Superoxide Production in Vascular Smooth Muscle Contributes to Oxidative Stress and Impaired Relaxation in Atherosclerosis

1998 • 631 citations

Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite

2002 • 606 citations

A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall

2000 • 596 citations

Does ADMA Cause Endothelial Dysfunction?

2000 • 590 citations

Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

1997 • 585 citations

Improvement of Nitric Oxide–Dependent Vasodilatation by HMG-CoA Reductase Inhibitors Through Attenuation of Endothelial Superoxide Anion Formation

2000 • 520 citations

LDL Cholesterol Upregulates Synthesis of Asymmetrical Dimethylarginine in Human Endothelial Cells

2000 • 487 citations

Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion

1995 • 479 citations

Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function

1999 • 474 citations

Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers

2000 • 448 citations

Expression of phagocyte NADPH oxidase components in human endothelial cells

1996 • 432 citations

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

1991 • 429 citations

Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus

2000 • 424 citations

Transcriptional and Posttranscriptional Regulation of Endothelial Nitric Oxide Synthase Expression by Hydrogen Peroxide

2000 • 424 citations

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti‐proliferative as well as In vivo anti‐tumor activity

1989 • 414 citations

Superoxide Anion From the Adventitia of the Rat Thoracic Aorta Inactivates Nitric Oxide

1998 • 387 citations

Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E

2000 • 333 citations

Ascorbate Restores Endothelium-Dependent Vasodilation Impaired by Acute Hyperglycemia in Humans

2001 • 321 citations

Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

1996 • 312 citations

S -nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase

2002 • 297 citations

Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus

1997 • 282 citations

Inhibition of Protein Kinase Cβ Prevents Impaired Endothelium-Dependent Vasodilation Caused by Hyperglycemia in Humans

2002 • 274 citations

Cerivastatin, a Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor, Improves Endothelial Function in Elderly Diabetic Patients Within 3 Days

2001 • 258 citations

Vasodilator-Stimulated Phosphoprotein Serine 239 Phosphorylation as a Sensitive Monitor of Defective Nitric Oxide/cGMP Signaling and Endothelial Dysfunction

2000 • 255 citations

Vitamin C Improves Endothelium-Dependent Vasodilation in Patients With Insulin-Dependent Diabetes Mellitus

1998 • 254 citations

Estrogens Increase Transcription of the Human Endothelial NO Synthase Gene

1998 • 241 citations

Effects of Long-Term Nitroglycerin Treatment on Endothelial Nitric Oxide Synthase (NOS III) Gene Expression, NOS III–Mediated Superoxide Production, and Vascular NO Bioavailability

2000 • 237 citations

Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits.

1994 • 229 citations

Acute Amelioration of Diabetic Endothelial Dysfunction with a Derivative of the Nitric Oxide Synthase Cofactor, Tetrahydrobiopterin

1997 • 224 citations

Effect of Native and Oxidized Low-Density Lipoprotein on Endothelial Nitric Oxide and Superoxide Production

2000 • 222 citations

Effect of YC‐1, an NO‐independent, superoxide‐sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators

1997 • 220 citations

Are ACE Inhibitors a “Magic Bullet” Against Oxidative Stress?

2001 • 220 citations

Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus.

1997 • 220 citations

Downregulation of Soluble Guanylyl Cyclase in Young and Aging Spontaneously Hypertensive Rats

1999 • 205 citations

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1998 • 194 citations

Inhibition of Endothelial Nitric Oxide Synthase Activity by Protein Kinase C

1995 • 188 citations

Validation of Lucigenin as a Chemiluminescent Probe to Monitor Vascular Superoxide as Well as Basal Vascular Nitric Oxide Production

1999 • 187 citations

Improvement in endothelial function by angiotensin-converting enzyme inhibition in non–insulin-dependent diabetes mellitus

1999 • 174 citations

Protein kinase C-β contributes to NADPH oxidase activation in neutrophils

2000 • 171 citations

Chemiluminescent Detection of Oxidants in Vascular Tissue

1999 • 160 citations

Vitamin E supplementation improves endothelial function in type I diabetes mellitus: a randomized, placebo-controlled study

2000 • 151 citations

Activation of Protein Kinase Cα and/or ε Enhances Transcription of the Human Endothelial Nitric Oxide Synthase Gene

1998 • 151 citations

Role of peroxynitrite in altered fetal-placental vascular reactivity in diabetes or preeclampsia

2000 • 140 citations

Losartan, an angiotensin type 1 receptor antagonist, improves endothelial function in non-insulin-dependent diabetes

2000 • 129 citations

Atorvastatin but not l-arginine improves endothelial function in type I diabetes mellitus: a double-blind study

2000 • 128 citations

Assembly and regulation of NADPH oxidase and nitric oxide synthase

1994 • 123 citations

Gene Transfer of Endothelial Nitric Oxide Synthase Improves Relaxation of Carotid Arteries From Diabetic Rabbits

2000 • 122 citations

Dietary antioxidant supplementation reduces lipid peroxidation but impairs vascular function in small mesenteric arteries of the streptozotocin-diabetic rat

1998 • 114 citations

Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan‐induced hyperglycaemia

1999 • 103 citations

Potential Functional Significance of Brain-Type and Muscle-Type Nitric Oxide Synthase I Expressed in Adventitia and Media of Rat Aorta

1999 • 92 citations

Role of superoxide anion and endothelium in vasoconstrictor action of prostaglandin endoperoxide

1992 • 90 citations

Reversal by L-arginine of a dysfunctional arginine/nitric oxide pathway in the endothelium of the genetic diabetic BB rat

1997 • 77 citations

Short-term oral administration of l-arginine reverses defective endothelium-dependent relaxation and cGMP generation in diabetes

1996 • 69 citations

Evaluation of the mechanism of endothelial dysfunction in the genetically-diabetic BB rat

1996 • 66 citations

Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle

1993 • 65 citations

Losartan, an angiotensin type 1 receptor antagonist, improves conduit vessel endothelial function in Type II diabetes

2001 • 65 citations

Role of superoxide dismutase in in vivo and in vitro nitrate tolerance

1999 • 57 citations

Quantification of Superoxide Radical Formation in Intact Vascular Tissue Using aCypridinaLuciferin Analog as an Alternative to Lucigenin

1998 • 50 citations

Vitamin E Normalizes Diacylglycerol—Protein Kinase C Activation Induced by Hyperglycemia in Rat Vascular Tissues

1996 • 44 citations

The Role of Protein Kinase C Activation in the Pathogenesis of Diabetic Vascular Complications

1999 • 42 citations

Endothelial dysfunction in Type 1 diabetes mellitus: relationship with LDL oxidation and the effects of vitamin E

1999 • 35 citations

Deleted Work

1955 • 0 citations