NAD(P)H Oxidase-derived Hydrogen Peroxide Mediates Endothelial Nitric Oxide Production in Response to Angiotensin II

Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress

2000 • 3,760 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

1997 • 831 citations

Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis

1999 • 689 citations

p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II

1998 • 657 citations

Activation of protein kinase C by tyrosine phosphorylation in response to H ₂ O ₂

1997 • 610 citations

Activation of the JAK-STAT pathway by reactive oxygen species

1998 • 566 citations

Role of p47 ^phox in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II

2002 • 566 citations

Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells

1999 • 563 citations

Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation

1999 • 558 citations

Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance.

1988 • 425 citations

Reactive oxygen species as mediators of angiotensin II signaling

2000 • 424 citations

Transcriptional and Posttranscriptional Regulation of Endothelial Nitric Oxide Synthase Expression by Hydrogen Peroxide

2000 • 424 citations

Diffusion of Nitric Oxide in the Aorta Wall Monitored in Situ by Porphyrinic Microsensors

1993 • 418 citations

p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

1995 • 409 citations

AT ₂ Receptor Stimulation Increases Aortic Cyclic GMP in SHRSP by a Kinin-Dependent Mechanism

1998 • 393 citations

Hydrogen Peroxide Activates Endothelial Nitric-oxide Synthase through Coordinated Phosphorylation and Dephosphorylation via a Phosphoinositide 3-Kinase-dependent Signaling Pathway

2002 • 378 citations

The AT ₁ -Type Angiotensin Receptor in Oxidative Stress and Atherogenesis

2002 • 366 citations

Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT ₂ ) angiotensin receptor

1999 • 316 citations

Angiotensin II-induced superoxide anion generation in human vascular endothelial cells Role of membrane-bound NADH-/NADPH-oxidases

1999 • 300 citations

c-Src Is Required for Oxidative Stress-mediated Activation of Big Mitogen-activated Protein Kinase 1 (BMK1)

1997 • 270 citations

o-Phenylenediamine-Modified Carbon Fiber Electrodes for the Detection of Nitric Oxide

1996 • 265 citations

Coronary Kinin Generation Mediates Nitric Oxide Release After Angiotensin Receptor Stimulation

1995 • 259 citations

Src and Cas Mediate JNK Activation but Not ERK1/2 and p38 Kinases by Reactive Oxygen Species

2000 • 257 citations

Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells

1998 • 211 citations

Expression of a functional neutrophil-type NADPH oxidase in cultured rat coronary microvascular endothelial cells

1998 • 188 citations

Nitric Oxide Diffusion in Membranes Determined by Fluorescence Quenching

1996 • 178 citations

Increase of reactive oxygen species (ROS) in endothelial cells by shear flow and involvement of ROS in shear-induced c-fos expression

1998 • 178 citations

Induction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca ²⁺ /Calmodulin-Dependent Protein Kinase II/Janus Kinase 2–Dependent Pathway

2001 • 157 citations

Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide.

1987 • 156 citations

Modulation of catalase peroxidatic and catalatic activity by nitric oxide

2001 • 126 citations

Effects of H2O2 on protein tyrosine phosphatase activity in HER14 cells

1994 • 121 citations

Spin Trapping of Vascular Nitric Oxide Using Colloid Fe(II)-Diethyldithiocarbamate

2000 • 102 citations

Expression of the transforming growth factor-β gene during growth inhibition following polyamine depletion

1998 • 94 citations

Coronary Microvascular Endothelial Cell Redox State in Left Ventricular Hypertrophy

2000 • 83 citations

Angiotensin II Activates Endothelial Constitutive Nitric Oxide Synthase via AT1 Receptors.

1996 • 80 citations

Role of nitric oxide in angiotensin IV-induced increases in cerebral blood flow

1998 • 54 citations

Selective Inhibition of the Renal Angiotensin Type 2 Receptor Increases Blood Pressure in Conscious Rats

2001 • 52 citations

Angiotensin II-Stimulated Nitric Oxide Release from Porcine Pulmonary Endothelium Is Mediated by Angiotensin IV

1999 • 35 citations