The evolution of free radicals and oxidative stress

Superoxide Dismutase

1969 • 12,578 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Antioxidants in Human Health and Disease

1996 • 1,689 citations

Superoxide radical inhibits catalase.

1982 • 1,274 citations

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1996 • 1,261 citations

Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide Dismutase

1974 • 1,109 citations

Role of superoxide dismutase in cancer: a review.

1979 • 976 citations

Isolation of superoxide dismutase mutants in Escherichia coli: is superoxide dismutase necessary for aerobic life?

1986 • 777 citations

Ischemic injury in the cat small intestine: Role of superoxide radicals

1982 • 771 citations

Role of redox potential and reactive oxygen species in stress signaling

1999 • 695 citations

Oxidative Stress in the Pathogenesis of Preeclampsia

1999 • 673 citations

Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

1980 • 628 citations

Inactivation of glutathione peroxidase by superoxide radical

1985 • 546 citations

An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease

1997 • 526 citations

Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia.

1995 • 484 citations

Superoxide dismutase and pulmonary oxygen toxicity

1974 • 462 citations

Superoxide Anion Production Is Increased in a Model of Genetic Hypertension

1999 • 413 citations

Oxygen-derived radicals: a link between reperfusion injury and inflammation.

1987 • 389 citations

Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury.

1998 • 334 citations

Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.

1994 • 291 citations

Cigarette smoking induces an increase in oxidative DNA damage, 8- hydroxydeoxyguanosine, in a central site of the human lung

1997 • 289 citations

Oxy-radicals in molecular biology and pathology

1989 • 262 citations

Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase

1991 • 259 citations

Redox signalling by transcription factors NF-κB and AP-1 in lymphocytes

1995 • 258 citations

Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase.

1995 • 244 citations

alpha, beta-Dihydroxyisovalerate dehydratase. A superoxide-sensitive enzyme.

1987 • 239 citations

Oxy-radical toxicity in catecholamine neurons.

1984 • 221 citations

Tat protein of human immunodeficiency virus type 1 represses expression of manganese superoxide dismutase in HeLa cells.

1993 • 212 citations

Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts.

1984 • 208 citations

Cooperativity between Oxidants and Tumor Necrosis Factor in the Activation of Nuclear Factor (NF)- κ B

1999 • 200 citations

A Role for Superoxide in Protein Kinase C Activation and Induction of Long-term Potentiation

1998 • 194 citations

Redox regulation of signal transduction in mammalian cells

2000 • 159 citations

Lipid peroxidation in ethanol poisoning: a critical reconsideration.

1985 • 153 citations

The toxicity of high-dose superoxide dismutase suggests that superoxide can both initiate and terminate lipid peroxidation in the reperfused heart☆

1994 • 148 citations

Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells.

1996 • 146 citations

Reactive Oxygen Species Activate p90 Ribosomal S6 Kinase via Fyn and Ras

2000 • 143 citations

Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase.

1994 • 139 citations

Mucosal reactive oxygen metabolite production in duodenal ulcer disease.

1992 • 138 citations

Evidence for increased lipid peroxidation in multiple sclerosis

1992 • 136 citations

Oxidative stress as a potential pathogenic mechanism in an animal model of Duchenne muscular dystrophy

1997 • 134 citations

Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells

1999 • 129 citations

Expression of manganese superoxide dismutase promotes cellular differentiation

1994 • 128 citations

Excess iron induces hepatic oxidative stress and transforming growth factor ?1 in genetic hemochromatosis

1997 • 120 citations

REACTIONS OF O^‐₂, H₂O₂ AND OTHER OXIDANTS WITH SULFHYDRYL ENZYMES‡

1978 • 118 citations

Free Radicals and Inflammation

2000 • 106 citations

Oxidative Processes and Antioxidants

1995 • 100 citations

Molecular basis of oxidative damage by leukocytes

1993 • 96 citations

The Role of Reactive Oxygen Metabolites in Glomerular Disease

1995 • 83 citations

Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus

1997 • 79 citations

Inactivation of mammalian brain glutamine synthetase by oxygen radicals

1988 • 75 citations

Complementary DNA encoding human colon cancer manganese superoxide dismutase and the expression of its gene in human cells.

1991 • 74 citations

Overexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cells.

1997 • 73 citations

ROLE OF OXIDANT STRESS IN THE ADULT RESPIRATORY DISTRESS SYNDROME

1996 • 71 citations

Role of O2− in neutrophil recruitment into sites of dermal and pulmonary vasculitis

1990 • 67 citations

ROLE OF OXIDANT STRESS IN THE ADULT RESPIRATORY DISTRESS SYNDROME

1996 • 61 citations

Interstitial equilibration of superoxide dismutase correlates with its protective effect in the isolated rabbit heart

1991 • 57 citations

Oxidative damage in human liver transplantation

1995 • 55 citations

Edema Formation Exacerbates Neurological and Histological Outcomes After Focal Cerebral Ischemia in CuZn-Superoxide Dismutase Gene Knockout Mutant Mice

1997 • 51 citations

Anti-inflammatory activity of various superoxide dismutases on polyarthritis in the Lewis rat

1990 • 42 citations

Oxygen free radicals stimulate fibroblast proliferation

1989 • 40 citations

Mitochondrial Injury by Ischemia and Reperfusion

1994 • 32 citations

Mutational analysis of the Cu/Zn superoxide dismutase gene in 23 familial and 69 sporadic cases of amyotrophic lateral sclerosis in Belgium

1999 • 31 citations

Effect of oxygen radicals and hyperoxia on rat heart ornithine decarboxylase activity

1982 • 26 citations

Stimulation by xanthine oxidase of 3T3 Swiss fibroblasts and human lymphocytes

1991 • 25 citations

Oxidative inactivation of alpha 1-proteinase inhibitor by alveolar epithelial type II cells

1993 • 22 citations

Free radicals generated by xanthine oxidase-hypoxanthine damage adenylate cyclase and ATPase in gerbil cerebral cortex

1987 • 19 citations

Inhibitory effect of superoxide radicals on cardiac myofibrillar ATPase activity.

1985 • 13 citations

[68] Elevated mutagenesis in bacterial mutants lacking superoxide dismutase

1990 • 11 citations

Superoxide scavenging activity in experimental liver transplantation

1995 • 6 citations

Superoxide scavenging activity in experimental liver transplantation

1995 • 4 citations